Current molecular diagnostics of breast cancer and the potential incorporation of microRNA
Although comprehensive molecular diagnostics and personalized medicine have sparked excitement among researchers and clinicians, they have yet to be fully incorporated into today s standard of care. This is despite the discovery of disease-related oncogenes, tumor-suppressor genes and protein biomar...
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| Veröffentlicht in: | Expert review of molecular diagnostics 2009-07, Vol.9 (5), p.455-466 |
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| container_title | Expert review of molecular diagnostics |
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| creator | Zoon, Christine K Starker, Elizabeth Q Wilson, Arianne M Emmert-Buck, Michael R Libutti, Steven K Tangrea, Michael A |
| description | Although comprehensive molecular diagnostics and personalized medicine have sparked excitement among researchers and clinicians, they have yet to be fully incorporated into today s standard of care. This is despite the discovery of disease-related oncogenes, tumor-suppressor genes and protein biomarkers, as well as other biological anomalies related to cancer. Each year, new tests are released that could potentially supplement or surpass standard methods of diagnosis, including serum, protein and gene expression analyses. All of these novel approaches have shown great promise, but initial enthusiasm has diminished as difficulties in reproducibility, expense, standardization and proof of significance beyond current protocols have emerged. This review will focus on current and novel molecular diagnostic tools applied to breast cancer with special attention to the exciting new field of microRNA analysis. |
| doi_str_mv | 10.1586/erm.09.25 |
| format | Article |
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This is despite the discovery of disease-related oncogenes, tumor-suppressor genes and protein biomarkers, as well as other biological anomalies related to cancer. Each year, new tests are released that could potentially supplement or surpass standard methods of diagnosis, including serum, protein and gene expression analyses. All of these novel approaches have shown great promise, but initial enthusiasm has diminished as difficulties in reproducibility, expense, standardization and proof of significance beyond current protocols have emerged. This review will focus on current and novel molecular diagnostic tools applied to breast cancer with special attention to the exciting new field of microRNA analysis.</description><subject>Biomarkers, Tumor - genetics</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - metabolism</subject><subject>Cancer</subject><subject>Diagnosis</subject><subject>Early Detection of Cancer</subject><subject>Female</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genetic aspects</subject><subject>Genetic screening</subject><subject>Humans</subject><subject>Medical Oncology - methods</subject><subject>Medical Oncology - trends</subject><subject>Methods</subject><subject>microarray</subject><subject>microRNA</subject><subject>MicroRNAs - metabolism</subject><subject>Models, Biological</subject><subject>Molecular Diagnostic Techniques</subject><subject>molecular diagnostics</subject><subject>predictive value</subject><subject>Prognosis</subject><subject>prognostic value</subject><subject>Receptor, ErbB-2 - metabolism</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Receptors, Progesterone - metabolism</subject><issn>1473-7159</issn><issn>1744-8352</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkUuLFDEUhQtRnLF14R-QwoXgotrKq5JshKbxBYOCzMpNSKVudWdIJe1NlTL_3jTd6IxKFgnJd87NvaeqnpN2TYTq3gBO61avqXhQXRLJeaOYoA_LmUvWSCL0RfUk55u2pZ2Q4nF1QbRQLWftZfVtuyBCnOspBXBLsFgP3u5iyrN3uU5j3SPYPNfORgdY2zjU8x7qQ5qLyttQ--gSHhLa2ad4FEzeYfr6efO0ejTakOHZeV9V1-_fXW8_NldfPnzabq4aJ6iaGy2oU0L3A9VjpxmRnWMDSKVGxmjfy75TlEsYOg186KhjtFVD31NwTioKbFW9Pdkeln6CwZVvoQ3mgH6yeGuS9eb-S_R7s0s_DJVCkTKFVfXqbIDp-wJ5NpPPDkKwEdKSTSe5kIofwZd_gTdpwVh6M0QrIooXK9D6BO1sAOPjmEpRV9YAZTApwujL_YYySSnvWlIEr0-CMrWcEcbfXyetOcZrSrym1YaKwr642-sf8pxnAfgJOBbGyf5MGAYz29uQcMQSoc-G_c-X3ZPtwYZ57yzCnRb_Uf0CqyDGAQ</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Zoon, Christine K</creator><creator>Starker, Elizabeth Q</creator><creator>Wilson, Arianne M</creator><creator>Emmert-Buck, Michael R</creator><creator>Libutti, Steven K</creator><creator>Tangrea, Michael A</creator><general>Informa Healthcare</general><general>Taylor & Francis</general><general>Expert Reviews Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090701</creationdate><title>Current molecular diagnostics of breast cancer and the potential incorporation of microRNA</title><author>Zoon, Christine K ; 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| subjects | Biomarkers, Tumor - genetics Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - metabolism Cancer Diagnosis Early Detection of Cancer Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Genetic aspects Genetic screening Humans Medical Oncology - methods Medical Oncology - trends Methods microarray microRNA MicroRNAs - metabolism Models, Biological Molecular Diagnostic Techniques molecular diagnostics predictive value Prognosis prognostic value Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism |
| title | Current molecular diagnostics of breast cancer and the potential incorporation of microRNA |
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