Aggregation Processes in Hybrid Nanosystem Polymer/Nanosilver/Cisplatin
Hybrid nanosystems consisting of star-like copolymer Dextran-graft-Polyacrylamide in the anionic form (D-g-PAA(PE)), silver nanoparticles (AgNPs), and cisplatin (cis-Pt) have been synthesized in water and characterized by TEM, DLS, FTIR, and UV-Vis spectroscopies. It is shown that cis-Pt forms a com...
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| Veröffentlicht in: | Ukrainian journal of physics (Kiev) 2018-07, Vol.63 (6), p.513 |
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| container_title | Ukrainian journal of physics (Kiev) |
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| creator | Kutsevol, N. Naumenko, A. Chumachenko, V. Yeshchenko, O. Harahuts, Yu Pavlenko, V. |
| description | Hybrid nanosystems consisting of star-like copolymer Dextran-graft-Polyacrylamide in the anionic form (D-g-PAA(PE)), silver nanoparticles (AgNPs), and cisplatin (cis-Pt) have been synthesized in water and characterized by TEM, DLS, FTIR, and UV-Vis spectroscopies. It is shown that cis-Pt forms a complex with carboxylate groups of the polymer. For the ternary system Polymer/AgNPs/cis-Pt, a change in the hydrophilic-hydrophobic balance of a polymer molecule (due to the complexation with cis-Pt) and the aggregation of macromolecules, as well as to some agglomeration AgNPs, are revealed. The decrease of the antitumor efficiency of the hybrid ternary nanosystem Polymer/AgNPs/cis-Pt in comparison with the Polymer/cis-Pt system is discussed. |
| doi_str_mv | 10.15407/ujpe63.6.513 |
| format | Article |
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It is shown that cis-Pt forms a complex with carboxylate groups of the polymer. For the ternary system Polymer/AgNPs/cis-Pt, a change in the hydrophilic-hydrophobic balance of a polymer molecule (due to the complexation with cis-Pt) and the aggregation of macromolecules, as well as to some agglomeration AgNPs, are revealed. The decrease of the antitumor efficiency of the hybrid ternary nanosystem Polymer/AgNPs/cis-Pt in comparison with the Polymer/cis-Pt system is discussed.</description><identifier>ISSN: 2071-0186</identifier><identifier>EISSN: 2071-0194</identifier><identifier>DOI: 10.15407/ujpe63.6.513</identifier><language>eng</language><ispartof>Ukrainian journal of physics (Kiev), 2018-07, Vol.63 (6), p.513</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c237t-adf49880d31119ab979dd706522d2e6d0c4e9faee09fe46b0911ad6763b3276b3</citedby><cites>FETCH-LOGICAL-c237t-adf49880d31119ab979dd706522d2e6d0c4e9faee09fe46b0911ad6763b3276b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Kutsevol, N.</creatorcontrib><creatorcontrib>Naumenko, A.</creatorcontrib><creatorcontrib>Chumachenko, V.</creatorcontrib><creatorcontrib>Yeshchenko, O.</creatorcontrib><creatorcontrib>Harahuts, Yu</creatorcontrib><creatorcontrib>Pavlenko, V.</creatorcontrib><title>Aggregation Processes in Hybrid Nanosystem Polymer/Nanosilver/Cisplatin</title><title>Ukrainian journal of physics (Kiev)</title><description>Hybrid nanosystems consisting of star-like copolymer Dextran-graft-Polyacrylamide in the anionic form (D-g-PAA(PE)), silver nanoparticles (AgNPs), and cisplatin (cis-Pt) have been synthesized in water and characterized by TEM, DLS, FTIR, and UV-Vis spectroscopies. It is shown that cis-Pt forms a complex with carboxylate groups of the polymer. For the ternary system Polymer/AgNPs/cis-Pt, a change in the hydrophilic-hydrophobic balance of a polymer molecule (due to the complexation with cis-Pt) and the aggregation of macromolecules, as well as to some agglomeration AgNPs, are revealed. 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| ispartof | Ukrainian journal of physics (Kiev), 2018-07, Vol.63 (6), p.513 |
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| title | Aggregation Processes in Hybrid Nanosystem Polymer/Nanosilver/Cisplatin |
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