HEPATOPROTECTIVE ACTION OF AQUEOUS EXTRACT OF Artemisia pallens lEAVES IN CLOFIBRATE AND PHENOL TREATED FRESHWATER FISH Pangasius Sp
Aim: The key motive was to investigate the toxicological upshot of clofibrate and phenol prescribed under human medicine, having potential in water and sediments contamination via input from sewage treatment plants as active pharmaceutical ingredients’ discharge into the environment had kindled pres...
Gespeichert in:
| Veröffentlicht in: | Biotechnologia acta 2021-04, Vol.14 (2), p.67-78 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 78 |
|---|---|
| container_issue | 2 |
| container_start_page | 67 |
| container_title | Biotechnologia acta |
| container_volume | 14 |
| creator | Geetha, B. Vijaya |
| description | Aim: The key motive was to investigate the toxicological upshot of clofibrate and phenol prescribed under human medicine, having potential in water and sediments contamination via input from sewage treatment plants as active pharmaceutical ingredients’ discharge into the environment had kindled present catastrophic effects upon the aquatic ecosystem. Methods: The present study involved, exposing the fish model, Pangasius sp. after acclimatizing them at a suitable LC50 concentration of selective drugs. Their toxic effects were studied in terms of oxidative stress markers, antioxidant status, and protein damage levels in the occupancies under the bioremediation source, Artemisia pallens and further supported by histopathological and cortisol level studies. Results: The results’ comparison between fish maintained under the bioremediation source, when exposed to clofibrate and phenol resulted in severe oxidative stress (significant *P |
| doi_str_mv | 10.15407/biotech14.02.067 |
| format | Article |
| fullrecord | <record><control><sourceid>crossref</sourceid><recordid>TN_cdi_crossref_primary_10_15407_biotech14_02_067</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_15407_biotech14_02_067</sourcerecordid><originalsourceid>FETCH-LOGICAL-c907-1cd03890144dbdca3d4ae0b6c68337d1df5f5eb9925a80049d625fd82989cc633</originalsourceid><addsrcrecordid>eNo9kMtOg0AYRidGE5vaB3A3L0D9hxluS6SDkBAGgdbuyDADiuktTF2498El1XT1fTmLszgIPRJYEoeB99QOx3OnPghbgr0E17tBM5sRsDzP3d5ev0Pu0cKYTwAgQJnD7Bn6SXgR1qIoRc2jOt1wHE4jcixiHL6uuVhXmG_rcqIXNJ67_WAGiU9yt-sOBu94uOEVTnMcZSJOn8uwnhz5ChcJz0WG65JPZIXjklfJ23RLHKdVggt5eJdm-DK4Oj2gu17uTLf43zmqY15HiZWJlzQKM0sF4FlEaaB-AIQx3WolqWayg9ZVrk-pp4nund7p2iCwHekDsEC7ttNr3w78QCmX0jkif1o1Ho0Zu745jcNejt8NgeYSsrmGbMBuppD0F1oMYOM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>HEPATOPROTECTIVE ACTION OF AQUEOUS EXTRACT OF Artemisia pallens lEAVES IN CLOFIBRATE AND PHENOL TREATED FRESHWATER FISH Pangasius Sp</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Geetha, B. Vijaya</creator><creatorcontrib>Geetha, B. Vijaya ; Department of Biotechnology , Rajalakshmi Engineering College, Rajalakshmi Nagar , Chennai, India</creatorcontrib><description><![CDATA[Aim: The key motive was to investigate the toxicological upshot of clofibrate and phenol prescribed under human medicine, having potential in water and sediments contamination via input from sewage treatment plants as active pharmaceutical ingredients’ discharge into the environment had kindled present catastrophic effects upon the aquatic ecosystem. Methods: The present study involved, exposing the fish model, Pangasius sp. after acclimatizing them at a suitable LC50 concentration of selective drugs. Their toxic effects were studied in terms of oxidative stress markers, antioxidant status, and protein damage levels in the occupancies under the bioremediation source, Artemisia pallens and further supported by histopathological and cortisol level studies. Results: The results’ comparison between fish maintained under the bioremediation source, when exposed to clofibrate and phenol resulted in severe oxidative stress (significant *P<0.001, #P<0.001) with significant alterations in antioxidant enzyme activities (significant *P<0.001, #P<0.001), histopathological changes and cortisol levels. In the fish exposed to clofibrate and phenol, the significant increase in cortisol level (significant *P<0.05, #P<0.05) may confer distinctive effects on the cell survival by protecting against oxidative stress-induced changes. Conclusion: Since these results varied with the dwelling of the bioremediation source, determination of oxidative stress biomarkers in Pangasius along with Artemisia pallens may serve as a convenient approach for pollution biomonitoring.]]></description><identifier>ISSN: 2410-7751</identifier><identifier>EISSN: 2410-776X</identifier><identifier>DOI: 10.15407/biotech14.02.067</identifier><language>eng</language><ispartof>Biotechnologia acta, 2021-04, Vol.14 (2), p.67-78</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c907-1cd03890144dbdca3d4ae0b6c68337d1df5f5eb9925a80049d625fd82989cc633</citedby><cites>FETCH-LOGICAL-c907-1cd03890144dbdca3d4ae0b6c68337d1df5f5eb9925a80049d625fd82989cc633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids></links><search><creatorcontrib>Geetha, B. Vijaya</creatorcontrib><creatorcontrib>Department of Biotechnology , Rajalakshmi Engineering College, Rajalakshmi Nagar , Chennai, India</creatorcontrib><title>HEPATOPROTECTIVE ACTION OF AQUEOUS EXTRACT OF Artemisia pallens lEAVES IN CLOFIBRATE AND PHENOL TREATED FRESHWATER FISH Pangasius Sp</title><title>Biotechnologia acta</title><description><![CDATA[Aim: The key motive was to investigate the toxicological upshot of clofibrate and phenol prescribed under human medicine, having potential in water and sediments contamination via input from sewage treatment plants as active pharmaceutical ingredients’ discharge into the environment had kindled present catastrophic effects upon the aquatic ecosystem. Methods: The present study involved, exposing the fish model, Pangasius sp. after acclimatizing them at a suitable LC50 concentration of selective drugs. Their toxic effects were studied in terms of oxidative stress markers, antioxidant status, and protein damage levels in the occupancies under the bioremediation source, Artemisia pallens and further supported by histopathological and cortisol level studies. Results: The results’ comparison between fish maintained under the bioremediation source, when exposed to clofibrate and phenol resulted in severe oxidative stress (significant *P<0.001, #P<0.001) with significant alterations in antioxidant enzyme activities (significant *P<0.001, #P<0.001), histopathological changes and cortisol levels. In the fish exposed to clofibrate and phenol, the significant increase in cortisol level (significant *P<0.05, #P<0.05) may confer distinctive effects on the cell survival by protecting against oxidative stress-induced changes. Conclusion: Since these results varied with the dwelling of the bioremediation source, determination of oxidative stress biomarkers in Pangasius along with Artemisia pallens may serve as a convenient approach for pollution biomonitoring.]]></description><issn>2410-7751</issn><issn>2410-776X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNo9kMtOg0AYRidGE5vaB3A3L0D9hxluS6SDkBAGgdbuyDADiuktTF2498El1XT1fTmLszgIPRJYEoeB99QOx3OnPghbgr0E17tBM5sRsDzP3d5ev0Pu0cKYTwAgQJnD7Bn6SXgR1qIoRc2jOt1wHE4jcixiHL6uuVhXmG_rcqIXNJ67_WAGiU9yt-sOBu94uOEVTnMcZSJOn8uwnhz5ChcJz0WG65JPZIXjklfJ23RLHKdVggt5eJdm-DK4Oj2gu17uTLf43zmqY15HiZWJlzQKM0sF4FlEaaB-AIQx3WolqWayg9ZVrk-pp4nund7p2iCwHekDsEC7ttNr3w78QCmX0jkif1o1Ho0Zu745jcNejt8NgeYSsrmGbMBuppD0F1oMYOM</recordid><startdate>202104</startdate><enddate>202104</enddate><creator>Geetha, B. Vijaya</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>202104</creationdate><title>HEPATOPROTECTIVE ACTION OF AQUEOUS EXTRACT OF Artemisia pallens lEAVES IN CLOFIBRATE AND PHENOL TREATED FRESHWATER FISH Pangasius Sp</title><author>Geetha, B. Vijaya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c907-1cd03890144dbdca3d4ae0b6c68337d1df5f5eb9925a80049d625fd82989cc633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Geetha, B. Vijaya</creatorcontrib><creatorcontrib>Department of Biotechnology , Rajalakshmi Engineering College, Rajalakshmi Nagar , Chennai, India</creatorcontrib><collection>CrossRef</collection><jtitle>Biotechnologia acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Geetha, B. Vijaya</au><aucorp>Department of Biotechnology , Rajalakshmi Engineering College, Rajalakshmi Nagar , Chennai, India</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HEPATOPROTECTIVE ACTION OF AQUEOUS EXTRACT OF Artemisia pallens lEAVES IN CLOFIBRATE AND PHENOL TREATED FRESHWATER FISH Pangasius Sp</atitle><jtitle>Biotechnologia acta</jtitle><date>2021-04</date><risdate>2021</risdate><volume>14</volume><issue>2</issue><spage>67</spage><epage>78</epage><pages>67-78</pages><issn>2410-7751</issn><eissn>2410-776X</eissn><abstract><![CDATA[Aim: The key motive was to investigate the toxicological upshot of clofibrate and phenol prescribed under human medicine, having potential in water and sediments contamination via input from sewage treatment plants as active pharmaceutical ingredients’ discharge into the environment had kindled present catastrophic effects upon the aquatic ecosystem. Methods: The present study involved, exposing the fish model, Pangasius sp. after acclimatizing them at a suitable LC50 concentration of selective drugs. Their toxic effects were studied in terms of oxidative stress markers, antioxidant status, and protein damage levels in the occupancies under the bioremediation source, Artemisia pallens and further supported by histopathological and cortisol level studies. Results: The results’ comparison between fish maintained under the bioremediation source, when exposed to clofibrate and phenol resulted in severe oxidative stress (significant *P<0.001, #P<0.001) with significant alterations in antioxidant enzyme activities (significant *P<0.001, #P<0.001), histopathological changes and cortisol levels. In the fish exposed to clofibrate and phenol, the significant increase in cortisol level (significant *P<0.05, #P<0.05) may confer distinctive effects on the cell survival by protecting against oxidative stress-induced changes. Conclusion: Since these results varied with the dwelling of the bioremediation source, determination of oxidative stress biomarkers in Pangasius along with Artemisia pallens may serve as a convenient approach for pollution biomonitoring.]]></abstract><doi>10.15407/biotech14.02.067</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2410-7751 |
| ispartof | Biotechnologia acta, 2021-04, Vol.14 (2), p.67-78 |
| issn | 2410-7751 2410-776X |
| language | eng |
| recordid | cdi_crossref_primary_10_15407_biotech14_02_067 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| title | HEPATOPROTECTIVE ACTION OF AQUEOUS EXTRACT OF Artemisia pallens lEAVES IN CLOFIBRATE AND PHENOL TREATED FRESHWATER FISH Pangasius Sp |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T14%3A07%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-crossref&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=HEPATOPROTECTIVE%20ACTION%20OF%20AQUEOUS%20EXTRACT%20OF%20Artemisia%20pallens%20lEAVES%20IN%20CLOFIBRATE%20AND%20PHENOL%20TREATED%20FRESHWATER%20FISH%20Pangasius%20Sp&rft.jtitle=Biotechnologia%20acta&rft.au=Geetha,%20B.%20Vijaya&rft.aucorp=Department%20of%20Biotechnology%20,%20Rajalakshmi%20Engineering%20College,%20Rajalakshmi%20Nagar%20,%20Chennai,%20India&rft.date=2021-04&rft.volume=14&rft.issue=2&rft.spage=67&rft.epage=78&rft.pages=67-78&rft.issn=2410-7751&rft.eissn=2410-776X&rft_id=info:doi/10.15407/biotech14.02.067&rft_dat=%3Ccrossref%3E10_15407_biotech14_02_067%3C/crossref%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |