A Rare Case of Autoimmune Enteropathy Associated with Autoimmune Hepatitis
A 74-year-old woman was admitted for weight loss, abdominal pain and diarrhea for a year. Blood tests showed elevated transaminases, cholestasis and hyperbilirubinemia. Capsule endoscopy revealed extensively scattered lymphangiectasias, shortened villi and erosions in the jejunum and ileum. The hist...
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| Veröffentlicht in: | Journal of gastrointestinal and liver diseases : JGLD 2023-06, Vol.32 (2), p.257-260 |
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| container_title | Journal of gastrointestinal and liver diseases : JGLD |
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| creator | Correia, Francisca Garrido, Isabel Chaves, Vanessa Peixoto, Armando Lopes, Joanne Macedo, Guilherme Almeida, Jorge |
| description | A 74-year-old woman was admitted for weight loss, abdominal pain and diarrhea for a year. Blood tests showed elevated transaminases, cholestasis and hyperbilirubinemia. Capsule endoscopy revealed extensively scattered lymphangiectasias, shortened villi and erosions in the jejunum and ileum. The histological examination of the small bowel mucosa biopsies evidenced severe mucosal atrophy and crypt hyperplasia, without significant intraepithelial lymphocytosis. The clinical picture, lack of response to a gluten-free diet and endoscopic and histopathologic findings were compatible with autoimmune enteropathy. Simultaneously, autoimmune hepatitis was also diagnosed. The patient showed significant improvement after starting treatment with prednisolone and azathioprine. To our knowledge, this is the first case of autoimmune enteropathy diagnosed simultaneously with autoimmune hepatitis. |
| doi_str_mv | 10.15403/jgld-4624 |
| format | Article |
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Blood tests showed elevated transaminases, cholestasis and hyperbilirubinemia. Capsule endoscopy revealed extensively scattered lymphangiectasias, shortened villi and erosions in the jejunum and ileum. The histological examination of the small bowel mucosa biopsies evidenced severe mucosal atrophy and crypt hyperplasia, without significant intraepithelial lymphocytosis. The clinical picture, lack of response to a gluten-free diet and endoscopic and histopathologic findings were compatible with autoimmune enteropathy. Simultaneously, autoimmune hepatitis was also diagnosed. The patient showed significant improvement after starting treatment with prednisolone and azathioprine. 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Blood tests showed elevated transaminases, cholestasis and hyperbilirubinemia. Capsule endoscopy revealed extensively scattered lymphangiectasias, shortened villi and erosions in the jejunum and ileum. The histological examination of the small bowel mucosa biopsies evidenced severe mucosal atrophy and crypt hyperplasia, without significant intraepithelial lymphocytosis. The clinical picture, lack of response to a gluten-free diet and endoscopic and histopathologic findings were compatible with autoimmune enteropathy. Simultaneously, autoimmune hepatitis was also diagnosed. The patient showed significant improvement after starting treatment with prednisolone and azathioprine. To our knowledge, this is the first case of autoimmune enteropathy diagnosed simultaneously with autoimmune hepatitis.</description><subject>Aged</subject><subject>Celiac Disease - diagnosis</subject><subject>Diarrhea</subject><subject>Female</subject><subject>Hepatitis, Autoimmune - complications</subject><subject>Hepatitis, Autoimmune - diagnosis</subject><subject>Hepatitis, Autoimmune - drug therapy</subject><subject>Humans</subject><subject>Intestinal Mucosa - pathology</subject><subject>Polyendocrinopathies, Autoimmune - diagnosis</subject><subject>Polyendocrinopathies, Autoimmune - pathology</subject><issn>1841-8724</issn><issn>1842-1121</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpN0M9LwzAUwPEgipvTi3-A5CxU8_KjSY-lbE4ZCKLnkrSJ61jXkqTI_nu7TcXTe4cPj8cXoVsgDyA4YY-bz22d8JTyMzQFxWkCQOH8uEOiJOUTdBXChpA0JVJeogmTjAuRiSl6yfGb9hYXOljcOZwPsWvadthZPN9F67tex_Ue5yF0VaOjrfFXE9f_2dKOpIlNuEYXTm-DvfmZM_SxmL8Xy2T1-vRc5KukosBionVWM0ccKJNakEIwlxqVKQIq1ZVjzEpulJSmzlxWmfFLSUGw2mgiBaWMzdD96W7luxC8dWXvm1b7fQmkPAYpD0HKQ5AR351wP5jW1n_0twD7Bt_6W7c</recordid><startdate>20230622</startdate><enddate>20230622</enddate><creator>Correia, Francisca</creator><creator>Garrido, Isabel</creator><creator>Chaves, Vanessa</creator><creator>Peixoto, Armando</creator><creator>Lopes, Joanne</creator><creator>Macedo, Guilherme</creator><creator>Almeida, Jorge</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20230622</creationdate><title>A Rare Case of Autoimmune Enteropathy Associated with Autoimmune Hepatitis</title><author>Correia, Francisca ; Garrido, Isabel ; Chaves, Vanessa ; Peixoto, Armando ; Lopes, Joanne ; Macedo, Guilherme ; Almeida, Jorge</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c213t-aa9d3f0f18b6e17553f6b8980186acf33e74b877bd9f9cb59572153dba0752233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aged</topic><topic>Celiac Disease - diagnosis</topic><topic>Diarrhea</topic><topic>Female</topic><topic>Hepatitis, Autoimmune - complications</topic><topic>Hepatitis, Autoimmune - diagnosis</topic><topic>Hepatitis, Autoimmune - drug therapy</topic><topic>Humans</topic><topic>Intestinal Mucosa - pathology</topic><topic>Polyendocrinopathies, Autoimmune - diagnosis</topic><topic>Polyendocrinopathies, Autoimmune - pathology</topic><toplevel>online_resources</toplevel><creatorcontrib>Correia, Francisca</creatorcontrib><creatorcontrib>Garrido, Isabel</creatorcontrib><creatorcontrib>Chaves, Vanessa</creatorcontrib><creatorcontrib>Peixoto, Armando</creatorcontrib><creatorcontrib>Lopes, Joanne</creatorcontrib><creatorcontrib>Macedo, Guilherme</creatorcontrib><creatorcontrib>Almeida, Jorge</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of gastrointestinal and liver diseases : JGLD</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Correia, Francisca</au><au>Garrido, Isabel</au><au>Chaves, Vanessa</au><au>Peixoto, Armando</au><au>Lopes, Joanne</au><au>Macedo, Guilherme</au><au>Almeida, Jorge</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Rare Case of Autoimmune Enteropathy Associated with Autoimmune Hepatitis</atitle><jtitle>Journal of gastrointestinal and liver diseases : JGLD</jtitle><addtitle>J Gastrointestin Liver Dis</addtitle><date>2023-06-22</date><risdate>2023</risdate><volume>32</volume><issue>2</issue><spage>257</spage><epage>260</epage><pages>257-260</pages><issn>1841-8724</issn><eissn>1842-1121</eissn><abstract>A 74-year-old woman was admitted for weight loss, abdominal pain and diarrhea for a year. 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| identifier | ISSN: 1841-8724 |
| ispartof | Journal of gastrointestinal and liver diseases : JGLD, 2023-06, Vol.32 (2), p.257-260 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Celiac Disease - diagnosis Diarrhea Female Hepatitis, Autoimmune - complications Hepatitis, Autoimmune - diagnosis Hepatitis, Autoimmune - drug therapy Humans Intestinal Mucosa - pathology Polyendocrinopathies, Autoimmune - diagnosis Polyendocrinopathies, Autoimmune - pathology |
| title | A Rare Case of Autoimmune Enteropathy Associated with Autoimmune Hepatitis |
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