Background Data for Hematological and Blood Chemical Examinations in Juvenile Beagles
As the first step to get historical background data for physiological examinations in juvenile dogs, hematology and blood chemistry data obtained from juvenile beagle dogs (less than 3 months of age) used in the control group of toxicity studies conducted in our laboratory were summarized and compar...
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| Veröffentlicht in: | Experimental Animals 2013, Vol.62(1), pp.1-7 |
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| container_title | Experimental Animals |
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| creator | ISHII, Toshiya HORI, Hisako ISHIGAMI, Makoto MIZUGUCHI, Hiroyasu WATANABE, Dai |
| description | As the first step to get historical background data for physiological examinations in juvenile dogs, hematology and blood chemistry data obtained from juvenile beagle dogs (less than 3 months of age) used in the control group of toxicity studies conducted in our laboratory were summarized and compared with those obtained from adult beagle dogs (6 months of age). In the hematological examination, growth of beagle dogs was shown to be associated with increases in erythrocyte parameters and with decreases in reticulocyte and leukocyte counts. In the blood chemical examination, growth of beagle dogs was shown to be associated with increases in aspartate aminotransferase, alanine aminotransferase, and creatinine and with decreases in creatine phosphokinase, glucose, total cholesterol, and calcium. The differential leukocyte ratio showed no age relation, but the actual count showed a tendency toward decrease. Alkaline phosphatase showed a tendency to increase from 0 months of age to 3 months of age, but it decreased at 6 months of age. The present results were roughly similar to those previously reported. |
| doi_str_mv | 10.1538/expanim.62.1 |
| format | Article |
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In the hematological examination, growth of beagle dogs was shown to be associated with increases in erythrocyte parameters and with decreases in reticulocyte and leukocyte counts. In the blood chemical examination, growth of beagle dogs was shown to be associated with increases in aspartate aminotransferase, alanine aminotransferase, and creatinine and with decreases in creatine phosphokinase, glucose, total cholesterol, and calcium. The differential leukocyte ratio showed no age relation, but the actual count showed a tendency toward decrease. Alkaline phosphatase showed a tendency to increase from 0 months of age to 3 months of age, but it decreased at 6 months of age. The present results were roughly similar to those previously reported.</description><identifier>ISSN: 1341-1357</identifier><identifier>EISSN: 1881-7122</identifier><identifier>DOI: 10.1538/expanim.62.1</identifier><identifier>PMID: 23357940</identifier><language>eng</language><publisher>Japan: Japanese Association for Laboratory Animal Science</publisher><subject>Aging ; Alanine Transaminase - blood ; Animals ; Aspartate Aminotransferases - blood ; Blood Cell Count ; Blood Chemical Analysis ; blood chemical examination ; Blood Glucose ; Calcium - blood ; Cholesterol - blood ; Creatine Kinase - blood ; Creatinine - blood ; Dogs - growth & development ; Female ; Hematologic Tests ; hematological examination ; juvenile dog ; Male ; safety study ; Toxicity Tests</subject><ispartof>Experimental Animals, 2013, Vol.62(1), pp.1-7</ispartof><rights>2013 Japanese Association for Laboratory Animal Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-b86dd002d8c7e83742ac613ee7a76922288632b0fa6f43551df5becff1763e9f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23357940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ISHII, Toshiya</creatorcontrib><creatorcontrib>HORI, Hisako</creatorcontrib><creatorcontrib>ISHIGAMI, Makoto</creatorcontrib><creatorcontrib>MIZUGUCHI, Hiroyasu</creatorcontrib><creatorcontrib>WATANABE, Dai</creatorcontrib><title>Background Data for Hematological and Blood Chemical Examinations in Juvenile Beagles</title><title>Experimental Animals</title><addtitle>Exp Anim</addtitle><description>As the first step to get historical background data for physiological examinations in juvenile dogs, hematology and blood chemistry data obtained from juvenile beagle dogs (less than 3 months of age) used in the control group of toxicity studies conducted in our laboratory were summarized and compared with those obtained from adult beagle dogs (6 months of age). In the hematological examination, growth of beagle dogs was shown to be associated with increases in erythrocyte parameters and with decreases in reticulocyte and leukocyte counts. In the blood chemical examination, growth of beagle dogs was shown to be associated with increases in aspartate aminotransferase, alanine aminotransferase, and creatinine and with decreases in creatine phosphokinase, glucose, total cholesterol, and calcium. The differential leukocyte ratio showed no age relation, but the actual count showed a tendency toward decrease. Alkaline phosphatase showed a tendency to increase from 0 months of age to 3 months of age, but it decreased at 6 months of age. The present results were roughly similar to those previously reported.</description><subject>Aging</subject><subject>Alanine Transaminase - blood</subject><subject>Animals</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Blood Cell Count</subject><subject>Blood Chemical Analysis</subject><subject>blood chemical examination</subject><subject>Blood Glucose</subject><subject>Calcium - blood</subject><subject>Cholesterol - blood</subject><subject>Creatine Kinase - blood</subject><subject>Creatinine - blood</subject><subject>Dogs - growth & development</subject><subject>Female</subject><subject>Hematologic Tests</subject><subject>hematological examination</subject><subject>juvenile dog</subject><subject>Male</subject><subject>safety study</subject><subject>Toxicity Tests</subject><issn>1341-1357</issn><issn>1881-7122</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkM1PwkAQxTdGI4jePJv9AyzuR9ttj4IoGhIvcm6m29my2A-yWwz-91ZAEi8zk_d-eZk8Qm45G_NIJg-420Bj63EsxvyMDHmS8EBxIc77W4Y84DJSA3Ll_ZoxoZRIL8lAyF5MQzYkywnoz9K126agT9ABNa2jc6yha6u2tBoqCr01qdq2oNMV1ntptoPaNtDZtvHUNvRt-4WNrZBOEMoK_TW5MFB5vDnuEVk-zz6m82Dx_vI6fVwEOpKiC_IkLor-qyLRChOpQgE65hJRgYpTIUSSxFLkzEBsQhlFvDBRjtoYrmKJqZEjcn_I1a713qHJNs7W4L4zzrLfdrJjO1ksMt7jdwd8s81rLE7wXx09MDsAa99BiScAXGd1hf_S9kNkjEl28vUKXIaN_AHvpXs1</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>ISHII, Toshiya</creator><creator>HORI, Hisako</creator><creator>ISHIGAMI, Makoto</creator><creator>MIZUGUCHI, Hiroyasu</creator><creator>WATANABE, Dai</creator><general>Japanese Association for Laboratory Animal Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2013</creationdate><title>Background Data for Hematological and Blood Chemical Examinations in Juvenile Beagles</title><author>ISHII, Toshiya ; HORI, Hisako ; ISHIGAMI, Makoto ; MIZUGUCHI, Hiroyasu ; WATANABE, Dai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-b86dd002d8c7e83742ac613ee7a76922288632b0fa6f43551df5becff1763e9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aging</topic><topic>Alanine Transaminase - blood</topic><topic>Animals</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Blood Cell Count</topic><topic>Blood Chemical Analysis</topic><topic>blood chemical examination</topic><topic>Blood Glucose</topic><topic>Calcium - blood</topic><topic>Cholesterol - blood</topic><topic>Creatine Kinase - blood</topic><topic>Creatinine - blood</topic><topic>Dogs - growth & development</topic><topic>Female</topic><topic>Hematologic Tests</topic><topic>hematological examination</topic><topic>juvenile dog</topic><topic>Male</topic><topic>safety study</topic><topic>Toxicity Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ISHII, Toshiya</creatorcontrib><creatorcontrib>HORI, Hisako</creatorcontrib><creatorcontrib>ISHIGAMI, Makoto</creatorcontrib><creatorcontrib>MIZUGUCHI, Hiroyasu</creatorcontrib><creatorcontrib>WATANABE, Dai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Experimental Animals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ISHII, Toshiya</au><au>HORI, Hisako</au><au>ISHIGAMI, Makoto</au><au>MIZUGUCHI, Hiroyasu</au><au>WATANABE, Dai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Background Data for Hematological and Blood Chemical Examinations in Juvenile Beagles</atitle><jtitle>Experimental Animals</jtitle><addtitle>Exp Anim</addtitle><date>2013</date><risdate>2013</risdate><volume>62</volume><issue>1</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>1341-1357</issn><eissn>1881-7122</eissn><abstract>As the first step to get historical background data for physiological examinations in juvenile dogs, hematology and blood chemistry data obtained from juvenile beagle dogs (less than 3 months of age) used in the control group of toxicity studies conducted in our laboratory were summarized and compared with those obtained from adult beagle dogs (6 months of age). In the hematological examination, growth of beagle dogs was shown to be associated with increases in erythrocyte parameters and with decreases in reticulocyte and leukocyte counts. In the blood chemical examination, growth of beagle dogs was shown to be associated with increases in aspartate aminotransferase, alanine aminotransferase, and creatinine and with decreases in creatine phosphokinase, glucose, total cholesterol, and calcium. The differential leukocyte ratio showed no age relation, but the actual count showed a tendency toward decrease. Alkaline phosphatase showed a tendency to increase from 0 months of age to 3 months of age, but it decreased at 6 months of age. The present results were roughly similar to those previously reported.</abstract><cop>Japan</cop><pub>Japanese Association for Laboratory Animal Science</pub><pmid>23357940</pmid><doi>10.1538/expanim.62.1</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Aging Alanine Transaminase - blood Animals Aspartate Aminotransferases - blood Blood Cell Count Blood Chemical Analysis blood chemical examination Blood Glucose Calcium - blood Cholesterol - blood Creatine Kinase - blood Creatinine - blood Dogs - growth & development Female Hematologic Tests hematological examination juvenile dog Male safety study Toxicity Tests |
| title | Background Data for Hematological and Blood Chemical Examinations in Juvenile Beagles |
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