Evaluation of Ready-to-use Liquid Reagents for Clinical Chemistry in Laboratory Animals
We evaluated the ready-to-use liquid reagents for clinical chemistry (6 tests), to assess their suitability for use in the toxicology laboratory setting. Hitachi 736 automated analyzer was used for the analyses. The evaluation included the following studies: Precision, Linearity, Effects of interfer...
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| Veröffentlicht in: | Experimental Animals 1999, Vol.48(2), pp.133-136 |
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| container_title | Experimental Animals |
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| creator | TABATA, Hajime NAGAMATSU, Nami SAKAZUME, Masashi MATSUZAWA, Toshiaki |
| description | We evaluated the ready-to-use liquid reagents for clinical chemistry (6 tests), to assess their suitability for use in the toxicology laboratory setting. Hitachi 736 automated analyzer was used for the analyses. The evaluation included the following studies: Precision, Linearity, Effects of interference substances such as hemolytic hemoglobin, bilirubin, turbidity to the analytical values and correlation to the solid reagents, which are prepared each time they are needed. The precision and linearity data were within the reagents' specifications. Results of comparison of the liquid reagents and the solid reagents in analyzing plasma samples of rats, dogs and monkeys were generally good except for a bias in results for GOT and GPT, regardless of the animal species tested. It is concluded that these types of liquid reagents can be used in clinical pathology examinations in animal studies. |
| doi_str_mv | 10.1538/expanim.48.133 |
| format | Article |
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Hitachi 736 automated analyzer was used for the analyses. The evaluation included the following studies: Precision, Linearity, Effects of interference substances such as hemolytic hemoglobin, bilirubin, turbidity to the analytical values and correlation to the solid reagents, which are prepared each time they are needed. The precision and linearity data were within the reagents' specifications. Results of comparison of the liquid reagents and the solid reagents in analyzing plasma samples of rats, dogs and monkeys were generally good except for a bias in results for GOT and GPT, regardless of the animal species tested. 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It is concluded that these types of liquid reagents can be used in clinical pathology examinations in animal studies.</description><subject>Animals</subject><subject>Animals, Laboratory</subject><subject>Clinical Chemistry Tests - standards</subject><subject>Dogs</subject><subject>Evaluation Studies as Topic</subject><subject>Haplorhini</subject><subject>Indicators and Reagents - standards</subject><subject>laboratory animals</subject><subject>liquid reagents</subject><subject>plasma clinical chemistry</subject><subject>Rats</subject><subject>Reproducibility of Results</subject><subject>Toxicity Tests - methods</subject><issn>1341-1357</issn><issn>1881-7122</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNUF1LwzAUDaK4OX31UfIHUvPRLe3jKPMDCoIoPpakvXEZXTuTVNy_N6Nj7OHm3uSeczg5CN0zmrC5yB7hb6c6u03SLGFCXKApyzJGJOP8Ms4iZYSJuZygG-83lHIpeX6NJowKmVIpp-hr9avaQQXbd7g3-B1UsyehJ4MHXNqfwTaHt2_ogsemd7hobWdr1eJiDVvrg9tj2-FS6d6p0MfbMrpRrb9FVyY2uDv2Gfp8Wn0UL6R8e34tliWpUyoCUcrwWEZxA1qLBYNoHRjP5rrJtZZK5kJRwyjNaN5orhvDBeMSmnoBnIOYoWTUrV3vvQNT7Vw04PYVo9UhoeqYUJVmVUwoEh5Gwm7QW2jO4GMkEVCMgI0P8eMngHLB1i2c6_HxiLKnbb1WroJO_APOt33C</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>TABATA, Hajime</creator><creator>NAGAMATSU, Nami</creator><creator>SAKAZUME, Masashi</creator><creator>MATSUZAWA, Toshiaki</creator><general>Japanese Association for Laboratory Animal Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1999</creationdate><title>Evaluation of Ready-to-use Liquid Reagents for Clinical Chemistry in Laboratory Animals</title><author>TABATA, Hajime ; NAGAMATSU, Nami ; SAKAZUME, Masashi ; MATSUZAWA, Toshiaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-aaf2aaffa2febb361e712e1285bd9bb7a793a0f100809db2bdf23127edc6e22e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Animals, Laboratory</topic><topic>Clinical Chemistry Tests - standards</topic><topic>Dogs</topic><topic>Evaluation Studies as Topic</topic><topic>Haplorhini</topic><topic>Indicators and Reagents - standards</topic><topic>laboratory animals</topic><topic>liquid reagents</topic><topic>plasma clinical chemistry</topic><topic>Rats</topic><topic>Reproducibility of Results</topic><topic>Toxicity Tests - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TABATA, Hajime</creatorcontrib><creatorcontrib>NAGAMATSU, Nami</creatorcontrib><creatorcontrib>SAKAZUME, Masashi</creatorcontrib><creatorcontrib>MATSUZAWA, Toshiaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Experimental Animals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TABATA, Hajime</au><au>NAGAMATSU, Nami</au><au>SAKAZUME, Masashi</au><au>MATSUZAWA, Toshiaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Ready-to-use Liquid Reagents for Clinical Chemistry in Laboratory Animals</atitle><jtitle>Experimental Animals</jtitle><addtitle>Exp Anim</addtitle><date>1999</date><risdate>1999</risdate><volume>48</volume><issue>2</issue><spage>133</spage><epage>136</epage><pages>133-136</pages><issn>1341-1357</issn><eissn>1881-7122</eissn><abstract>We evaluated the ready-to-use liquid reagents for clinical chemistry (6 tests), to assess their suitability for use in the toxicology laboratory setting. 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| ispartof | Experimental Animals, 1999, Vol.48(2), pp.133-136 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library; J-STAGE |
| subjects | Animals Animals, Laboratory Clinical Chemistry Tests - standards Dogs Evaluation Studies as Topic Haplorhini Indicators and Reagents - standards laboratory animals liquid reagents plasma clinical chemistry Rats Reproducibility of Results Toxicity Tests - methods |
| title | Evaluation of Ready-to-use Liquid Reagents for Clinical Chemistry in Laboratory Animals |
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