Process of the Development of T-2 Toxin-induced Apoptosis in the Lymphoid Organs of Mice

Female ICR:CD-1 mice orally treated with 10 mg/kg b.w. of T-2 toxin were killed at 1, 3, 6, 9, 12, 24 and 48 hr after treatment (HAT) and subjected to examination of the process of the development of T-2 toxin-induced apoptosis in the thymus and spleen. The early ultrastructural changes in lymphocyt...

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Veröffentlicht in:	Experimental Animals 1997, Vol.46(2), pp.117-126
Hauptverfasser:	SHINOZUKA, Junko, GUANMIN, Li, UETSUKA, Koji, NAKAYAMA, Hiroyuki, DOI, Kunio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects apoptotic cell death DNA Fragmentation - drug effects Female lymphocytes Lymphocytes - drug effects Lymphocytes - metabolism Lymphocytes - pathology Lymphoid Tissue - drug effects Lymphoid Tissue - metabolism Lymphoid Tissue - pathology Mice Mice, Inbred ICR mouse spleen Spleen - drug effects Spleen - metabolism Spleen - pathology T-2 toxin T-2 Toxin - toxicity thymus Thymus Gland - drug effects Thymus Gland - metabolism Thymus Gland - pathology Time Factors
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