Pentoxifylline Prevents Driamycin-Induced Myocardial Fibrosis and Apoptosis in Rats

Adriamycin (ADR) is a potent antineoplastic agent, but long-term treatment is limited by its cumulative, life-threatening cardiomyopathy. Recently, a few reports have shown that pentoxifylline (PTX) might produce cardioprotection in cardiac dysfunction. Here, we investigated the protective effects o...

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Veröffentlicht in:	International Heart Journal 2015, Vol.56(6), pp.651-655
Hauptverfasser:	Zang, Zhijun, Li, Shujuan, Lin, Yuese, Li, Xuandi, Li, Yunquan, Qin, Youzhen, Wang, Huishen, Jiang, Meihua, Zhu, Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Antineoplastic Agents - pharmacology Cardiomyopathies - chemically induced Cardiomyopathies - metabolism Cardiomyopathies - pathology Cardiomyopathies - prevention & control Cardiomyopathy Cardiotonic Agents - pharmacology Caspase 3 - metabolism Disease Models, Animal Doxorubicin - pharmacology Hepatocyte Growth Factor - metabolism Models, Cardiovascular Myocardium - metabolism Myocardium - pathology Pentoxifylline - pharmacology Rats
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