Antihypertensive Effect of 4 (-2'-Nitrophenyl)-2, 6-Dimethyl-1, 4-Dihydropyridine-3, 5-Dicarbonic Acid Dimethylester (Nifedipine, Bay-a 1040), a New Coronary Dilator
Oral administration of 10mg. of Bay-a 1040, a new coronary dilator, produced a marked reduction of arterial pressure which was associated with a consistent decrease in peripheral vascular resistance and an increase in cardiac output and stroke volume. Changes in heart rate and left ventricular work...
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| Veröffentlicht in: | Japanese Heart Journal 1972, Vol.13(2), pp.128-135 |
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| container_end_page | 135 |
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| container_issue | 2 |
| container_start_page | 128 |
| container_title | Japanese Heart Journal |
| container_volume | 13 |
| creator | MURAKAMI, Mototaka MURAKAMI, Eiji TAKEKOSHI, Noboru TSUCHIYA, Masayuki KIN, Takeo ONOE, Tamehisa TAKEUCHI, Nobuo FUNATSU, Toshiro HARA, Shigeki ISHISE, Shozo MIFUNE, Junichiro MAEDA, Masahiro |
| description | Oral administration of 10mg. of Bay-a 1040, a new coronary dilator, produced a marked reduction of arterial pressure which was associated with a consistent decrease in peripheral vascular resistance and an increase in cardiac output and stroke volume. Changes in heart rate and left ventricular work were variable. In 20 hypertensive patients treated with the drug in doses of 10mg. per day, a modest antihypertensive effect was achieved. Side effects including dryness of the mouth and burning sensation in face and legs, were observed in few patients. |
| doi_str_mv | 10.1536/ihj.13.128 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0021-4868 |
| ispartof | Japanese Heart Journal, 1972, Vol.13(2), pp.128-135 |
| issn | 0021-4868 1348-673X |
| language | eng |
| recordid | cdi_crossref_primary_10_1536_ihj_13_128 |
| source | J-STAGE Free; EZB-FREE-00999 freely available EZB journals |
| subjects | Bay-a1040 Cardiac output Heart rate Left ventricular work Systolic pressure Total peripheral resistance |
| title | Antihypertensive Effect of 4 (-2'-Nitrophenyl)-2, 6-Dimethyl-1, 4-Dihydropyridine-3, 5-Dicarbonic Acid Dimethylester (Nifedipine, Bay-a 1040), a New Coronary Dilator |
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