Prevalence of Mandibular Second Premolar Agenesis in Individuals and Associated Factors: A Meta-Analysis

Background: The purposes of this study were to determine the prevalence and patterns of mandibular second premolar agenesis in individuals by meta-analysis methodology.Methods: Two investigators conducted a literature search independently by inclusion criteria to reveal articles on mandibular second premolar agenesis. PubMed, Google Scholar, Ovid Medline, Web of Science Core Collection databases were scanned and a total of 3,988 studies were initially extracted from all databases, then 12 articles were selected which met inclusion and exclusion criteria for the meta-analysis.Results: The estimated overall prevalence of mandibular second premolar in individuals was 3.26 %. No statistically significant difference was found in the prevalence of mandibular second premolar agenesis by gender [95 % Cl: 1.18 (0.96, 1.45); p>0.05]. Males were found to have a significantly higher prevalence of unilateral mandibular second premolar agenesis than females (combined OR 0.69; 95 % CI: 0.38-1.25; p