Effect of triiodothyronine administration on estrogen receptor contents in peripuberal Sertoli cells
Panno ML, Sisci D, Salerno M, Lanzino M, Mauro L, Morrone EG, Pezzi V, Palmero S. Fugassa E, Andò S. Effect of triiodothyronine administration on estrogen receptor contents in peripuberal Sertoli cells. Eur J Endocrinol 1996:134:633–8. ISSN 0804–4643 The effects of thyroid hormone on androgen metabo...
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| creator | PANNO, M. L SISCI, D SALERNO, M LANZINO, M MAURO, L MORRONE, E. G PEZZI, V PALMERO, S FUGASSA, E ANDO, S |
| description | Panno ML, Sisci D, Salerno M, Lanzino M, Mauro L, Morrone EG, Pezzi V, Palmero S. Fugassa E, Andò S. Effect of triiodothyronine administration on estrogen receptor contents in peripuberal Sertoli cells. Eur J Endocrinol 1996:134:633–8. ISSN 0804–4643 The effects of thyroid hormone on androgen metabolism in peripuberal Sertoli cells through the inhibition of estradiol production have been reported previously. It was our intention to investigate further the possible role of thyroid hormone on the interaction between testicular steroids and Sertoli cells by analyzing the effects of triiodothyronine (T3) on estrogen receptor content in 2-, 3- and 4week-old euthyroid rats. Triiodothyronine treatment (3 μg/100 body wt per day) given during the last week prior to sacrifice resulted in reduced testicular growth in 2-week-old animals. Sertoli cells from all groups were cultured initially under basal conditions for the first 24 h and subsequently in the presence of testosterone and/or T3 for the additional 24 h. The in vitro addition of T3 induced a decrease of estrogen receptors (ERs) in 2- and 3-week-old animals that appeared more pronounced especially in the presence of T3 and testosterone. When T3 was tested in vivo we noticed that the decrease of ER content was even greater in all three groups under the in vitro influence of both T3 and testosterone. In 3-week-old animals a simultaneous assay of ERs in both nuclear and cytoplasmic compartments was performed. The ER concentrations in the nucleus were closely related to those of the cytoplasm. The in vivo administration of T3 was responsible for a greater decrease of ERs in the nucleus than in the cytosol. On the basis of these results, and in agreement with our previous data, we speculate that the effect of T3 in the maturational events of Sertoli cells could involve both estradiol production and ER content. Sebastiano Andò Cattedra di Fisiopatologia Endocrina, Dipartimento di Biologia Cellulare, Università della Calabria, 87030 Arcavacata di Rende, Cosenza, Italy |
| doi_str_mv | 10.1530/eje.0.1340633 |
| format | Article |
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L ; SISCI, D ; SALERNO, M ; LANZINO, M ; MAURO, L ; MORRONE, E. G ; PEZZI, V ; PALMERO, S ; FUGASSA, E ; ANDO, S</creator><creatorcontrib>PANNO, M. L ; SISCI, D ; SALERNO, M ; LANZINO, M ; MAURO, L ; MORRONE, E. G ; PEZZI, V ; PALMERO, S ; FUGASSA, E ; ANDO, S</creatorcontrib><description>Panno ML, Sisci D, Salerno M, Lanzino M, Mauro L, Morrone EG, Pezzi V, Palmero S. Fugassa E, Andò S. Effect of triiodothyronine administration on estrogen receptor contents in peripuberal Sertoli cells. Eur J Endocrinol 1996:134:633–8. ISSN 0804–4643 The effects of thyroid hormone on androgen metabolism in peripuberal Sertoli cells through the inhibition of estradiol production have been reported previously. It was our intention to investigate further the possible role of thyroid hormone on the interaction between testicular steroids and Sertoli cells by analyzing the effects of triiodothyronine (T3) on estrogen receptor content in 2-, 3- and 4week-old euthyroid rats. Triiodothyronine treatment (3 μg/100 body wt per day) given during the last week prior to sacrifice resulted in reduced testicular growth in 2-week-old animals. Sertoli cells from all groups were cultured initially under basal conditions for the first 24 h and subsequently in the presence of testosterone and/or T3 for the additional 24 h. The in vitro addition of T3 induced a decrease of estrogen receptors (ERs) in 2- and 3-week-old animals that appeared more pronounced especially in the presence of T3 and testosterone. When T3 was tested in vivo we noticed that the decrease of ER content was even greater in all three groups under the in vitro influence of both T3 and testosterone. In 3-week-old animals a simultaneous assay of ERs in both nuclear and cytoplasmic compartments was performed. The ER concentrations in the nucleus were closely related to those of the cytoplasm. The in vivo administration of T3 was responsible for a greater decrease of ERs in the nucleus than in the cytosol. On the basis of these results, and in agreement with our previous data, we speculate that the effect of T3 in the maturational events of Sertoli cells could involve both estradiol production and ER content. Sebastiano Andò Cattedra di Fisiopatologia Endocrina, Dipartimento di Biologia Cellulare, Università della Calabria, 87030 Arcavacata di Rende, Cosenza, Italy</description><identifier>ISSN: 0804-4643</identifier><identifier>EISSN: 1479-683X</identifier><identifier>DOI: 10.1530/eje.0.1340633</identifier><identifier>PMID: 8664985</identifier><language>eng</language><publisher>Colchester: Portland Press</publisher><subject>Animals ; Binding, Competitive ; Biological and medical sciences ; Cell Nucleus - metabolism ; Cells, Cultured ; Cytosol - metabolism ; Diethylstilbestrol - metabolism ; Estradiol - metabolism ; EXPERIMENTAL STUDIES ; Fundamental and applied biological sciences. Psychology ; Hormones. Regulation ; Male ; Rats ; Rats, Wistar ; Receptors, Estrogen - metabolism ; Sertoli Cells - drug effects ; Sertoli Cells - metabolism ; Sertoli Cells - ultrastructure ; Sexual Maturation ; Testis - drug effects ; Testis - growth & development ; Testosterone - pharmacology ; Thyroid. Parathyroid. Ultimobranchial body ; Triiodothyronine - pharmacology ; Vertebrates: endocrinology</subject><ispartof>European journal of endocrinology, 1996-05, Vol.134 (5), p.633-638</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b390t-3ddef134f6e6386d9c4ef74800349faea0b450e933a70eb6414eece5175a27a33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3111115$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8664985$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PANNO, M. L</creatorcontrib><creatorcontrib>SISCI, D</creatorcontrib><creatorcontrib>SALERNO, M</creatorcontrib><creatorcontrib>LANZINO, M</creatorcontrib><creatorcontrib>MAURO, L</creatorcontrib><creatorcontrib>MORRONE, E. G</creatorcontrib><creatorcontrib>PEZZI, V</creatorcontrib><creatorcontrib>PALMERO, S</creatorcontrib><creatorcontrib>FUGASSA, E</creatorcontrib><creatorcontrib>ANDO, S</creatorcontrib><title>Effect of triiodothyronine administration on estrogen receptor contents in peripuberal Sertoli cells</title><title>European journal of endocrinology</title><addtitle>Eur J Endocrinol</addtitle><description>Panno ML, Sisci D, Salerno M, Lanzino M, Mauro L, Morrone EG, Pezzi V, Palmero S. Fugassa E, Andò S. Effect of triiodothyronine administration on estrogen receptor contents in peripuberal Sertoli cells. Eur J Endocrinol 1996:134:633–8. ISSN 0804–4643 The effects of thyroid hormone on androgen metabolism in peripuberal Sertoli cells through the inhibition of estradiol production have been reported previously. It was our intention to investigate further the possible role of thyroid hormone on the interaction between testicular steroids and Sertoli cells by analyzing the effects of triiodothyronine (T3) on estrogen receptor content in 2-, 3- and 4week-old euthyroid rats. Triiodothyronine treatment (3 μg/100 body wt per day) given during the last week prior to sacrifice resulted in reduced testicular growth in 2-week-old animals. Sertoli cells from all groups were cultured initially under basal conditions for the first 24 h and subsequently in the presence of testosterone and/or T3 for the additional 24 h. The in vitro addition of T3 induced a decrease of estrogen receptors (ERs) in 2- and 3-week-old animals that appeared more pronounced especially in the presence of T3 and testosterone. When T3 was tested in vivo we noticed that the decrease of ER content was even greater in all three groups under the in vitro influence of both T3 and testosterone. In 3-week-old animals a simultaneous assay of ERs in both nuclear and cytoplasmic compartments was performed. The ER concentrations in the nucleus were closely related to those of the cytoplasm. The in vivo administration of T3 was responsible for a greater decrease of ERs in the nucleus than in the cytosol. On the basis of these results, and in agreement with our previous data, we speculate that the effect of T3 in the maturational events of Sertoli cells could involve both estradiol production and ER content. Sebastiano Andò Cattedra di Fisiopatologia Endocrina, Dipartimento di Biologia Cellulare, Università della Calabria, 87030 Arcavacata di Rende, Cosenza, Italy</description><subject>Animals</subject><subject>Binding, Competitive</subject><subject>Biological and medical sciences</subject><subject>Cell Nucleus - metabolism</subject><subject>Cells, Cultured</subject><subject>Cytosol - metabolism</subject><subject>Diethylstilbestrol - metabolism</subject><subject>Estradiol - metabolism</subject><subject>EXPERIMENTAL STUDIES</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones. Regulation</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Sertoli Cells - drug effects</subject><subject>Sertoli Cells - metabolism</subject><subject>Sertoli Cells - ultrastructure</subject><subject>Sexual Maturation</subject><subject>Testis - drug effects</subject><subject>Testis - growth & development</subject><subject>Testosterone - pharmacology</subject><subject>Thyroid. Parathyroid. Ultimobranchial body</subject><subject>Triiodothyronine - pharmacology</subject><subject>Vertebrates: endocrinology</subject><issn>0804-4643</issn><issn>1479-683X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9LwzAUx4Moc06PHoUcvHYmvjRtjzL8BQMPKngrafqiGV1SknjYf29Gx66GQL7hfXh5-RByzdmSl8DucIPLHEEwCXBC5lxUTSFr-Dolc1YzUQgp4JxcxLhhjOfMZmRWSymaupyT_tEY1Il6Q1Ow1vc-_eyCd9YhVf3WOhtTUMl6R_PGfPHf6GhAjWPygWrvEroUqXV0xGDH3w6DGug7huQHSzUOQ7wkZ0YNEa8O54J8Pj1-rF6K9dvz6-phXXTQsFRA36PJHzESJdSyb7RAU4maMRCNUahYJ0qGDYCqGHZScIF5jpJXpbqvFMCCFFNfHXyMAU07BrtVYddy1u5ltVlWm-MkK_M3E5-n3mJ_pA92cv32UFdRq8EE5bSNRwz4fu0xmLDO-qht1mGN1eqfx_8AzE-Fog</recordid><startdate>19960501</startdate><enddate>19960501</enddate><creator>PANNO, M. L</creator><creator>SISCI, D</creator><creator>SALERNO, M</creator><creator>LANZINO, M</creator><creator>MAURO, L</creator><creator>MORRONE, E. 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Regulation</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Sertoli Cells - drug effects</topic><topic>Sertoli Cells - metabolism</topic><topic>Sertoli Cells - ultrastructure</topic><topic>Sexual Maturation</topic><topic>Testis - drug effects</topic><topic>Testis - growth & development</topic><topic>Testosterone - pharmacology</topic><topic>Thyroid. Parathyroid. Ultimobranchial body</topic><topic>Triiodothyronine - pharmacology</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PANNO, M. L</creatorcontrib><creatorcontrib>SISCI, D</creatorcontrib><creatorcontrib>SALERNO, M</creatorcontrib><creatorcontrib>LANZINO, M</creatorcontrib><creatorcontrib>MAURO, L</creatorcontrib><creatorcontrib>MORRONE, E. G</creatorcontrib><creatorcontrib>PEZZI, V</creatorcontrib><creatorcontrib>PALMERO, S</creatorcontrib><creatorcontrib>FUGASSA, E</creatorcontrib><creatorcontrib>ANDO, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PANNO, M. L</au><au>SISCI, D</au><au>SALERNO, M</au><au>LANZINO, M</au><au>MAURO, L</au><au>MORRONE, E. G</au><au>PEZZI, V</au><au>PALMERO, S</au><au>FUGASSA, E</au><au>ANDO, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of triiodothyronine administration on estrogen receptor contents in peripuberal Sertoli cells</atitle><jtitle>European journal of endocrinology</jtitle><addtitle>Eur J Endocrinol</addtitle><date>1996-05-01</date><risdate>1996</risdate><volume>134</volume><issue>5</issue><spage>633</spage><epage>638</epage><pages>633-638</pages><issn>0804-4643</issn><eissn>1479-683X</eissn><abstract>Panno ML, Sisci D, Salerno M, Lanzino M, Mauro L, Morrone EG, Pezzi V, Palmero S. Fugassa E, Andò S. Effect of triiodothyronine administration on estrogen receptor contents in peripuberal Sertoli cells. Eur J Endocrinol 1996:134:633–8. ISSN 0804–4643 The effects of thyroid hormone on androgen metabolism in peripuberal Sertoli cells through the inhibition of estradiol production have been reported previously. It was our intention to investigate further the possible role of thyroid hormone on the interaction between testicular steroids and Sertoli cells by analyzing the effects of triiodothyronine (T3) on estrogen receptor content in 2-, 3- and 4week-old euthyroid rats. Triiodothyronine treatment (3 μg/100 body wt per day) given during the last week prior to sacrifice resulted in reduced testicular growth in 2-week-old animals. Sertoli cells from all groups were cultured initially under basal conditions for the first 24 h and subsequently in the presence of testosterone and/or T3 for the additional 24 h. The in vitro addition of T3 induced a decrease of estrogen receptors (ERs) in 2- and 3-week-old animals that appeared more pronounced especially in the presence of T3 and testosterone. When T3 was tested in vivo we noticed that the decrease of ER content was even greater in all three groups under the in vitro influence of both T3 and testosterone. In 3-week-old animals a simultaneous assay of ERs in both nuclear and cytoplasmic compartments was performed. The ER concentrations in the nucleus were closely related to those of the cytoplasm. The in vivo administration of T3 was responsible for a greater decrease of ERs in the nucleus than in the cytosol. On the basis of these results, and in agreement with our previous data, we speculate that the effect of T3 in the maturational events of Sertoli cells could involve both estradiol production and ER content. Sebastiano Andò Cattedra di Fisiopatologia Endocrina, Dipartimento di Biologia Cellulare, Università della Calabria, 87030 Arcavacata di Rende, Cosenza, Italy</abstract><cop>Colchester</cop><pub>Portland Press</pub><pmid>8664985</pmid><doi>10.1530/eje.0.1340633</doi><tpages>6</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Animals Binding, Competitive Biological and medical sciences Cell Nucleus - metabolism Cells, Cultured Cytosol - metabolism Diethylstilbestrol - metabolism Estradiol - metabolism EXPERIMENTAL STUDIES Fundamental and applied biological sciences. Psychology Hormones. Regulation Male Rats Rats, Wistar Receptors, Estrogen - metabolism Sertoli Cells - drug effects Sertoli Cells - metabolism Sertoli Cells - ultrastructure Sexual Maturation Testis - drug effects Testis - growth & development Testosterone - pharmacology Thyroid. Parathyroid. Ultimobranchial body Triiodothyronine - pharmacology Vertebrates: endocrinology |
| title | Effect of triiodothyronine administration on estrogen receptor contents in peripuberal Sertoli cells |
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