Contraception by induction of luteinized unruptured follicles with short-acting low molecular weight FSH receptor agonists in female animal models

During recent decades minor innovative drugs have been developed for the female contraceptive market and they all contain steroidal progestagens (and estrogens) that act centrally and have side effects that can be attributed to this central action. In this study, we present an innovative tissue-spec...

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Veröffentlicht in:	Reproduction (Cambridge, England) England), 2011-12, Vol.142 (6), p.893-905
Hauptverfasser:	van de Lagemaat, R, van Koppen, C J, Krajnc-Franken, M A M, Folmer, B J B, van Diepen, H A, Mulders, S M, Timmers, C M
Format:	Artikel
Sprache:	eng
Schlagworte:	adverse effects agonists animal models Animals contraception Contraceptive Agents - pharmacology corpus luteum Dose-Response Relationship, Drug drugs estrogens Female females follicle-stimulating hormone Graafian follicles granulosa cells Guinea Pigs hormone receptors luteinization Macaca fascicularis menstruation Mice Models, Animal molecular weight monkeys oral administration Ovarian Follicle - drug effects ovulation Ovulation Inhibition periodicity pharmacokinetics progesterone Rats Receptors, FSH - agonists
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