Structural determinants for binding, activation, and functional selectivity of the angiotensin AT1 receptor

The renin–angiotensin system (RAS) plays an important role in the pathophysiology of cardiovascular disorders. Pharmacologic interventions targeting the RAS cascade have led to the discovery of renin inhibitors, angiotensin-converting enzyme inhibitors, and AT1 receptor blockers (ARBs) to treat hype...

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Veröffentlicht in:	Journal of molecular endocrinology 2014-10, Vol.53 (2), p.R71-R92
Hauptverfasser:	Balakumar, Pitchai, Jagadeesh, Gowraganahalli
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids Angiotensin II - metabolism Angiotensin II Type 1 Receptor Blockers - pharmacology Animals Binding Sites Humans Ligands Protein Binding Protein Interaction Domains and Motifs Receptor, Angiotensin, Type 1 - agonists Receptor, Angiotensin, Type 1 - chemistry Receptor, Angiotensin, Type 1 - genetics Receptor, Angiotensin, Type 1 - metabolism Review Signal Transduction
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