Enalapril and ASS inhibit tumor growth in a transgenic mouse model of islet cell tumors

Accumulating evidence suggests a role for angiotensin-converting enzymes involving the angiotensin II-receptor 1 (AT1-R) and the cyclooxygenase pathway in carcinogenesis. The effects of ASS and enalapril were assessed in vitro and in a transgenic mouse model of pancreatic neuroendocrine neoplasms (p...

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Veröffentlicht in:	Endocrine-related cancer 2014-10, Vol.21 (5), p.813-824
Hauptverfasser:	Fendrich, V, Lopez, C L, Manoharan, J, Maschuw, K, Wichmann, S, Baier, A, Holler, J P, Ramaswamy, A, Bartsch, D K, Waldmann, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma, Islet Cell - drug therapy Adenoma, Islet Cell - pathology Adult Aged Aged, 80 and over Angiotensin-Converting Enzyme Inhibitors - pharmacology Angiotensin-Converting Enzyme Inhibitors - therapeutic use Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Aspirin - pharmacology Aspirin - therapeutic use Cell Line, Tumor Cyclooxygenase Inhibitors - pharmacology Cyclooxygenase Inhibitors - therapeutic use Disease Models, Animal Enalapril - pharmacology Enalapril - therapeutic use Female Humans Male Mice, Transgenic Middle Aged NF-kappa B - metabolism Receptor, Angiotensin, Type 1 - metabolism Tumor Burden - drug effects Vascular Endothelial Growth Factor A - genetics Young Adult
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