Circulating progranulin levels in women with gestational diabetes mellitus and healthy controls during and after pregnancy
ObjectiveProgranulin (PGRN) was recently introduced as a novel marker of chronic inflammatory response in obesity and type 2 diabetes capable of directly affecting the insulin signaling pathway. This study aimed to investigate the role of PGRN in gestational diabetes mellitus (GDM), which is regarde...
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| Veröffentlicht in: | European journal of endocrinology 2012-10, Vol.167 (4), p.561-567 |
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| container_title | European journal of endocrinology |
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| creator | Todoric, Jelena Handisurya, Ammon Perkmann, Thomas Knapp, Bernhard Wagner, Oswald Tura, Andrea Pacini, Giovanni Esterbauer, Harald Kautzky-Willer, Alexandra |
| description | ObjectiveProgranulin (PGRN) was recently introduced as a novel marker of chronic inflammatory response in obesity and type 2 diabetes capable of directly affecting the insulin signaling pathway. This study aimed to investigate the role of PGRN in gestational diabetes mellitus (GDM), which is regarded as a model for early type 2 diabetes.MethodsPGRN serum levels were measured in 90 pregnant women (45 GDM and 45 normal glucose tolerance (NGT)). In addition, PGRN was measured during a 2-h, 75 g oral glucose tolerance test in 20 pregnant women (ten GDM and ten NGT) and in 16 of them post partum (ten GDM and six NGT).ResultsPGRN concentrations were significantly higher in pregnant women compared with post partum levels (536.79±31.81 vs 241.53±8.86, P |
| doi_str_mv | 10.1530/EJE-12-0060 |
| format | Article |
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This study aimed to investigate the role of PGRN in gestational diabetes mellitus (GDM), which is regarded as a model for early type 2 diabetes.MethodsPGRN serum levels were measured in 90 pregnant women (45 GDM and 45 normal glucose tolerance (NGT)). In addition, PGRN was measured during a 2-h, 75 g oral glucose tolerance test in 20 pregnant women (ten GDM and ten NGT) and in 16 of them post partum (ten GDM and six NGT).ResultsPGRN concentrations were significantly higher in pregnant women compared with post partum levels (536.79±31.81 vs 241.53±8.86, P<0.001). Multivariate regression analyses showed a strong positive correlation of PGRN with estrogen and progesterone. The insulinogenic index, a marker of early insulin secretion, displayed a positive correlation with PGRN, both during and after pregnancy (R=0.47, P=0.034; R=0.63, P=0.012). HbA1c and the oral glucose insulin sensitivity index showed significant post partum associations with PGRN (R=0.43, P=0.049; R=−0.65, P=0.009).ConclusionsPGRN concentrations are markedly lower after pregnancy regardless of the gestational glucose tolerance state. PGRN levels per se do not discriminate between mild GDM and NGT in pregnant women. Therefore, the development of GDM appears to be due to impaired β-cell function that is not related to PGRN effect.</description><identifier>ISSN: 0804-4643</identifier><identifier>EISSN: 1479-683X</identifier><identifier>DOI: 10.1530/EJE-12-0060</identifier><identifier>PMID: 22802426</identifier><language>eng</language><publisher>Bristol: BioScientifica</publisher><subject>Adult ; Area Under Curve ; Biological and medical sciences ; Case-Control Studies ; Clinical Study ; Diabetes, Gestational - blood ; Diabetes, Gestational - diagnosis ; Diagnosis, Differential ; Endocrinopathies ; Female ; Fundamental and applied biological sciences. Psychology ; Glucose Tolerance Test ; Health ; Humans ; Intercellular Signaling Peptides and Proteins - blood ; Medical sciences ; Postpartum Period - blood ; Postpartum Period - metabolism ; Pregnancy - blood ; Pregnancy - metabolism ; Pregnancy Trimester, Second - blood ; Pregnancy Trimester, Second - metabolism ; Progranulins ; Regression Analysis ; Severity of Illness Index ; Vertebrates: endocrinology</subject><ispartof>European journal of endocrinology, 2012-10, Vol.167 (4), p.561-567</ispartof><rights>2012 European Society of Endocrinology</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b440t-d76fd139ceed864ffb8e3c6984fc3f07e35e41e9e3b5a1cfc0f801f9003b59803</citedby><cites>FETCH-LOGICAL-b440t-d76fd139ceed864ffb8e3c6984fc3f07e35e41e9e3b5a1cfc0f801f9003b59803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26450309$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22802426$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Todoric, Jelena</creatorcontrib><creatorcontrib>Handisurya, Ammon</creatorcontrib><creatorcontrib>Perkmann, Thomas</creatorcontrib><creatorcontrib>Knapp, Bernhard</creatorcontrib><creatorcontrib>Wagner, Oswald</creatorcontrib><creatorcontrib>Tura, Andrea</creatorcontrib><creatorcontrib>Pacini, Giovanni</creatorcontrib><creatorcontrib>Esterbauer, Harald</creatorcontrib><creatorcontrib>Kautzky-Willer, Alexandra</creatorcontrib><title>Circulating progranulin levels in women with gestational diabetes mellitus and healthy controls during and after pregnancy</title><title>European journal of endocrinology</title><addtitle>Eur J Endocrinol</addtitle><description>ObjectiveProgranulin (PGRN) was recently introduced as a novel marker of chronic inflammatory response in obesity and type 2 diabetes capable of directly affecting the insulin signaling pathway. This study aimed to investigate the role of PGRN in gestational diabetes mellitus (GDM), which is regarded as a model for early type 2 diabetes.MethodsPGRN serum levels were measured in 90 pregnant women (45 GDM and 45 normal glucose tolerance (NGT)). In addition, PGRN was measured during a 2-h, 75 g oral glucose tolerance test in 20 pregnant women (ten GDM and ten NGT) and in 16 of them post partum (ten GDM and six NGT).ResultsPGRN concentrations were significantly higher in pregnant women compared with post partum levels (536.79±31.81 vs 241.53±8.86, P<0.001). Multivariate regression analyses showed a strong positive correlation of PGRN with estrogen and progesterone. The insulinogenic index, a marker of early insulin secretion, displayed a positive correlation with PGRN, both during and after pregnancy (R=0.47, P=0.034; R=0.63, P=0.012). HbA1c and the oral glucose insulin sensitivity index showed significant post partum associations with PGRN (R=0.43, P=0.049; R=−0.65, P=0.009).ConclusionsPGRN concentrations are markedly lower after pregnancy regardless of the gestational glucose tolerance state. PGRN levels per se do not discriminate between mild GDM and NGT in pregnant women. Therefore, the development of GDM appears to be due to impaired β-cell function that is not related to PGRN effect.</description><subject>Adult</subject><subject>Area Under Curve</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Clinical Study</subject><subject>Diabetes, Gestational - blood</subject><subject>Diabetes, Gestational - diagnosis</subject><subject>Diagnosis, Differential</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose Tolerance Test</subject><subject>Health</subject><subject>Humans</subject><subject>Intercellular Signaling Peptides and Proteins - blood</subject><subject>Medical sciences</subject><subject>Postpartum Period - blood</subject><subject>Postpartum Period - metabolism</subject><subject>Pregnancy - blood</subject><subject>Pregnancy - metabolism</subject><subject>Pregnancy Trimester, Second - blood</subject><subject>Pregnancy Trimester, Second - metabolism</subject><subject>Progranulins</subject><subject>Regression Analysis</subject><subject>Severity of Illness Index</subject><subject>Vertebrates: endocrinology</subject><issn>0804-4643</issn><issn>1479-683X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotlZP3iUXT7I62aTb3aOU-kXBi4K3JZudtJE0W5KsUn-9Ka168zIzzDy8Aw8h5wyu2ZjDzexplrE8AyjggAyZmFRZUfK3QzKEEkQmCsEH5CSEdwCWZjgmgzwvIRd5MSRfU-NVb2U0bkHXvlt46XprHLX4gTbQNH12K0zVxCVdYIgJ7Zy0tDWywYiBrtBaE_tApWvpEqWNyw1VnYu-SwFt77fR25vUEX16ggsnndqckiMtbcCzfR-R17vZy_Qhmz_fP05v51kjBMSsnRS6ZbxSiG1ZCK2bErkqqlJoxTVMkI9RMKyQN2PJlFagS2C6AkiLqgQ-Ile7XOW7EDzqeu3NSvpNzaDeGqyTwZrl9dZgoi929LpvVtj-sj_KEnC5B2RQ0uokTJnwxxViDByqxLEd15guKIMuGm2U_Pf5Nze3jD4</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Todoric, Jelena</creator><creator>Handisurya, Ammon</creator><creator>Perkmann, Thomas</creator><creator>Knapp, Bernhard</creator><creator>Wagner, Oswald</creator><creator>Tura, Andrea</creator><creator>Pacini, Giovanni</creator><creator>Esterbauer, Harald</creator><creator>Kautzky-Willer, Alexandra</creator><general>BioScientifica</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20121001</creationdate><title>Circulating progranulin levels in women with gestational diabetes mellitus and healthy controls during and after pregnancy</title><author>Todoric, Jelena ; Handisurya, Ammon ; Perkmann, Thomas ; Knapp, Bernhard ; Wagner, Oswald ; Tura, Andrea ; Pacini, Giovanni ; Esterbauer, Harald ; Kautzky-Willer, Alexandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b440t-d76fd139ceed864ffb8e3c6984fc3f07e35e41e9e3b5a1cfc0f801f9003b59803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Area Under Curve</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Clinical Study</topic><topic>Diabetes, Gestational - blood</topic><topic>Diabetes, Gestational - diagnosis</topic><topic>Diagnosis, Differential</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose Tolerance Test</topic><topic>Health</topic><topic>Humans</topic><topic>Intercellular Signaling Peptides and Proteins - blood</topic><topic>Medical sciences</topic><topic>Postpartum Period - blood</topic><topic>Postpartum Period - metabolism</topic><topic>Pregnancy - blood</topic><topic>Pregnancy - metabolism</topic><topic>Pregnancy Trimester, Second - blood</topic><topic>Pregnancy Trimester, Second - metabolism</topic><topic>Progranulins</topic><topic>Regression Analysis</topic><topic>Severity of Illness Index</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Todoric, Jelena</creatorcontrib><creatorcontrib>Handisurya, Ammon</creatorcontrib><creatorcontrib>Perkmann, Thomas</creatorcontrib><creatorcontrib>Knapp, Bernhard</creatorcontrib><creatorcontrib>Wagner, Oswald</creatorcontrib><creatorcontrib>Tura, Andrea</creatorcontrib><creatorcontrib>Pacini, Giovanni</creatorcontrib><creatorcontrib>Esterbauer, Harald</creatorcontrib><creatorcontrib>Kautzky-Willer, Alexandra</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Todoric, Jelena</au><au>Handisurya, Ammon</au><au>Perkmann, Thomas</au><au>Knapp, Bernhard</au><au>Wagner, Oswald</au><au>Tura, Andrea</au><au>Pacini, Giovanni</au><au>Esterbauer, Harald</au><au>Kautzky-Willer, Alexandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating progranulin levels in women with gestational diabetes mellitus and healthy controls during and after pregnancy</atitle><jtitle>European journal of endocrinology</jtitle><addtitle>Eur J Endocrinol</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>167</volume><issue>4</issue><spage>561</spage><epage>567</epage><pages>561-567</pages><issn>0804-4643</issn><eissn>1479-683X</eissn><abstract>ObjectiveProgranulin (PGRN) was recently introduced as a novel marker of chronic inflammatory response in obesity and type 2 diabetes capable of directly affecting the insulin signaling pathway. This study aimed to investigate the role of PGRN in gestational diabetes mellitus (GDM), which is regarded as a model for early type 2 diabetes.MethodsPGRN serum levels were measured in 90 pregnant women (45 GDM and 45 normal glucose tolerance (NGT)). In addition, PGRN was measured during a 2-h, 75 g oral glucose tolerance test in 20 pregnant women (ten GDM and ten NGT) and in 16 of them post partum (ten GDM and six NGT).ResultsPGRN concentrations were significantly higher in pregnant women compared with post partum levels (536.79±31.81 vs 241.53±8.86, P<0.001). Multivariate regression analyses showed a strong positive correlation of PGRN with estrogen and progesterone. The insulinogenic index, a marker of early insulin secretion, displayed a positive correlation with PGRN, both during and after pregnancy (R=0.47, P=0.034; R=0.63, P=0.012). HbA1c and the oral glucose insulin sensitivity index showed significant post partum associations with PGRN (R=0.43, P=0.049; R=−0.65, P=0.009).ConclusionsPGRN concentrations are markedly lower after pregnancy regardless of the gestational glucose tolerance state. PGRN levels per se do not discriminate between mild GDM and NGT in pregnant women. Therefore, the development of GDM appears to be due to impaired β-cell function that is not related to PGRN effect.</abstract><cop>Bristol</cop><pub>BioScientifica</pub><pmid>22802426</pmid><doi>10.1530/EJE-12-0060</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of endocrinology, 2012-10, Vol.167 (4), p.561-567 |
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| subjects | Adult Area Under Curve Biological and medical sciences Case-Control Studies Clinical Study Diabetes, Gestational - blood Diabetes, Gestational - diagnosis Diagnosis, Differential Endocrinopathies Female Fundamental and applied biological sciences. Psychology Glucose Tolerance Test Health Humans Intercellular Signaling Peptides and Proteins - blood Medical sciences Postpartum Period - blood Postpartum Period - metabolism Pregnancy - blood Pregnancy - metabolism Pregnancy Trimester, Second - blood Pregnancy Trimester, Second - metabolism Progranulins Regression Analysis Severity of Illness Index Vertebrates: endocrinology |
| title | Circulating progranulin levels in women with gestational diabetes mellitus and healthy controls during and after pregnancy |
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