Osteoclasts adapt to physioxia perturbation through DNA demethylation

Oxygen plays an important role in diverse biological processes. However, since quantitation of the partial pressure of cellular oxygen in vivo is challenging, the extent of oxygen perturbation in situ and its cellular response remains underexplored. Using two-photon phosphorescence lifetime imaging...

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Veröffentlicht in:	EMBO reports 2021-12, Vol.22 (12), p.e53035-n/a
Hauptverfasser:	Nishikawa, Keizo, Seno, Shigeto, Yoshihara, Toshitada, Narazaki, Ayako, Sugiura, Yuki, Shimizu, Reito, Kikuta, Junichi, Sakaguchi, Reiko, Suzuki, Norio, Takeda, Norihiko, Semba, Hiroaki, Yamamoto, Masamichi, Okuzaki, Daisuke, Motooka, Daisuke, Kobayashi, Yasuhiro, Suematsu, Makoto, Koseki, Haruhiko, Matsuda, Hideo, Yamamoto, Masayuki, Tobita, Seiji, Mori, Yasuo, Ishii, Masaru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological activity Biomedical materials bone metabolism Cell Differentiation - genetics Cell Hypoxia Demethylation Deoxyribonucleic acid DNA DNA Demethylation EMBO09 EMBO25 Energy metabolism Enzymes epigenetic regulation Gene expression Hypoxia Hypoxia - metabolism intravital imaging Metabolism Mice osteoclast Osteoclastogenesis Osteoclasts Osteoclasts - metabolism Oxygen Oxygen - metabolism Oxygen probes Oxygen tension Partial pressure Perturbation Phosphorescence Physiology Quantitation Sensors Translocation
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