Countering tumor-induced immunosuppression during immunotherapy for pancreatic cancer

Background: Vaccines for pancreatic cancer have been challenged by a number of factors, especially the immunosuppressive microenvironment within the tumor that allows for escape from immune surveillance. Objective/methods: We sought to identify results that define mechanisms of pancreatic-cancer-ass...

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Veröffentlicht in:	Expert opinion on biological therapy 2009-03, Vol.9 (3), p.331-339
Hauptverfasser:	Morse, Michael A, Hall, Joseph Robert, Plate, Janet MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals clinical trials Humans IL-10 Immune Tolerance - physiology immunosuppression Immunotherapy microenvironment myeloid-derived suppressor cells (MDSC) OX40 Pancreatic Neoplasms - therapy regulatory T cells (Tregs) TGFβ toll-like receptors (TLRs) tumor products tumor-associated macrophages (TAMs) vaccine
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