Role of interleukin-18 and plasma B-type natriuretic peptide in predicting requirement of kidney replacement therapy and/or mortality in individuals with acute heart disorders
Introduction: Although many predictive tools have already been developed, efforts are still proceeding to identify a reliable biomarker to predict the prognosis of the patients with acute heart disorders. Objectives: The aim was to evaluate the role of renal injury biomarkers (serum cystatin C, seru...
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Veröffentlicht in: | Journal of renal injury prevention 2019-12, Vol.8 (4), p.292-300 |
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creator | Hamzić-Mehmedbašić, Aida Rebić, Damir Valjevac, Amina Čubro, Hajrunisa Durak Nalbantić, Azra Herenda, Vedad Kulo Ćesić, Aida |
description | Introduction:
Although many predictive tools have already been developed, efforts are still proceeding to identify a reliable biomarker to predict the prognosis of the patients with acute heart disorders.
Objectives:
The aim was to evaluate the role of renal injury biomarkers (serum cystatin C, serum and urine interleukin-18, IL-18) and heart failure biomarkers (plasma B-type natriuretic peptide, BNP) in the prediction of the postdischarge requirement of renal replacement therapy (RRT) and/or 6-month mortality in patients with acute heart disorders.
Patients and Methods:
In patients diagnosed with acute heart disorders (acute heart failure [AHF] and/or acute coronary syndrome [ACS]) and admitted to the intensive care units, baseline clinical parameters, renal and cardiac biomarkers were determined. Patients were followed up for 6 months. The composite outcome was the postdischarge requirement of RRT and/or 6-month mortality.
Results:
Of 120 patients, 5.8% continued RRT after discharge. The 6-month mortality was 20%. Cox logistic regression analysis showed that urine IL-18 (P=0.021), plasma BNP (P=0.046), Acute Physiology and Chronic Health Evaluation (APACHE) II score (P=0.002), and left ventricular diastolic dysfunction (P=0.045) were independent predictors of the postdischarge requirement of RRT and/or 6-month mortality. For predicting RRT and/or 6-month mortality, using urine IL-18 cutoff value of 29.1 pg/mL showed 66.7% sensitivity and 67.7% specificity (area under the curve, AUC 0.70, P=0.003), while using plasma BNP cutoff value of 881.6 pg/mL showed 66.7% sensitivity and 70.8% specificity (AUC 0.76, P |
doi_str_mv | 10.15171/jrip.2019.54 |
format | Article |
fullrecord | <record><control><sourceid>crossref</sourceid><recordid>TN_cdi_crossref_primary_10_15171_jrip_2019_54</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_15171_jrip_2019_54</sourcerecordid><originalsourceid>FETCH-LOGICAL-c232t-5463aa9e67a3d4b7e6c4c9495d3db5c2420846328be11ae61348cda586ceb3533</originalsourceid><addsrcrecordid>eNpNkLtOw0AQRVcIJKKQkn5_wIn35UcJES8pEhKC2lrvTsgkjm3Ga5C_il_EJhRUM7q69xSHsWsRL4URqVjtCduljEW-NPqMzaTSJpJpJs7__Zds0XX7OI6FNLnQasa-X5oKeLPlWAegCvoD1pHIuK09byvbHS2_jcLQAq9tIOwJAjreQhvQwzjiLYFHF7B-5wQfPRIcoQ4T8YC-hmFMR447pWEHZNthoq8a4seGgq0wDBMIa4-f6HtbdfwLw45b1wfgO7AUuMeuIQ_UXbGL7diAxd-ds7f7u9f1Y7R5fnha32wiJ5UMkdGJsjaHJLXK6zKFxGmX69x45UvjpJZxNlZkVoIQFhKhdOa8NVnioFRGqTmLTlxHTdcRbIuW8GhpKERc_AovJuHFJLwwWv0AnCx5Dg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Role of interleukin-18 and plasma B-type natriuretic peptide in predicting requirement of kidney replacement therapy and/or mortality in individuals with acute heart disorders</title><source>EZB-FREE-00999 freely available EZB journals</source><creator>Hamzić-Mehmedbašić, Aida ; Rebić, Damir ; Valjevac, Amina ; Čubro, Hajrunisa ; Durak Nalbantić, Azra ; Herenda, Vedad ; Kulo Ćesić, Aida</creator><creatorcontrib>Hamzić-Mehmedbašić, Aida ; Rebić, Damir ; Valjevac, Amina ; Čubro, Hajrunisa ; Durak Nalbantić, Azra ; Herenda, Vedad ; Kulo Ćesić, Aida</creatorcontrib><description>Introduction:
Although many predictive tools have already been developed, efforts are still proceeding to identify a reliable biomarker to predict the prognosis of the patients with acute heart disorders.
Objectives:
The aim was to evaluate the role of renal injury biomarkers (serum cystatin C, serum and urine interleukin-18, IL-18) and heart failure biomarkers (plasma B-type natriuretic peptide, BNP) in the prediction of the postdischarge requirement of renal replacement therapy (RRT) and/or 6-month mortality in patients with acute heart disorders.
Patients and Methods:
In patients diagnosed with acute heart disorders (acute heart failure [AHF] and/or acute coronary syndrome [ACS]) and admitted to the intensive care units, baseline clinical parameters, renal and cardiac biomarkers were determined. Patients were followed up for 6 months. The composite outcome was the postdischarge requirement of RRT and/or 6-month mortality.
Results:
Of 120 patients, 5.8% continued RRT after discharge. The 6-month mortality was 20%. Cox logistic regression analysis showed that urine IL-18 (P=0.021), plasma BNP (P=0.046), Acute Physiology and Chronic Health Evaluation (APACHE) II score (P=0.002), and left ventricular diastolic dysfunction (P=0.045) were independent predictors of the postdischarge requirement of RRT and/or 6-month mortality. For predicting RRT and/or 6-month mortality, using urine IL-18 cutoff value of 29.1 pg/mL showed 66.7% sensitivity and 67.7% specificity (area under the curve, AUC 0.70, P=0.003), while using plasma BNP cutoff value of 881.6 pg/mL showed 66.7% sensitivity and 70.8% specificity (AUC 0.76, P<0.001).
Conclusion:
Urine IL-18 and plasma BNP are independently predictive for the postdischarge requirement of RRT and/or 6-month mortality in patients with acute heart disorders.</description><identifier>ISSN: 2345-2781</identifier><identifier>EISSN: 2345-2781</identifier><identifier>DOI: 10.15171/jrip.2019.54</identifier><language>eng</language><ispartof>Journal of renal injury prevention, 2019-12, Vol.8 (4), p.292-300</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-4967-7616</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Hamzić-Mehmedbašić, Aida</creatorcontrib><creatorcontrib>Rebić, Damir</creatorcontrib><creatorcontrib>Valjevac, Amina</creatorcontrib><creatorcontrib>Čubro, Hajrunisa</creatorcontrib><creatorcontrib>Durak Nalbantić, Azra</creatorcontrib><creatorcontrib>Herenda, Vedad</creatorcontrib><creatorcontrib>Kulo Ćesić, Aida</creatorcontrib><title>Role of interleukin-18 and plasma B-type natriuretic peptide in predicting requirement of kidney replacement therapy and/or mortality in individuals with acute heart disorders</title><title>Journal of renal injury prevention</title><description>Introduction:
Although many predictive tools have already been developed, efforts are still proceeding to identify a reliable biomarker to predict the prognosis of the patients with acute heart disorders.
Objectives:
The aim was to evaluate the role of renal injury biomarkers (serum cystatin C, serum and urine interleukin-18, IL-18) and heart failure biomarkers (plasma B-type natriuretic peptide, BNP) in the prediction of the postdischarge requirement of renal replacement therapy (RRT) and/or 6-month mortality in patients with acute heart disorders.
Patients and Methods:
In patients diagnosed with acute heart disorders (acute heart failure [AHF] and/or acute coronary syndrome [ACS]) and admitted to the intensive care units, baseline clinical parameters, renal and cardiac biomarkers were determined. Patients were followed up for 6 months. The composite outcome was the postdischarge requirement of RRT and/or 6-month mortality.
Results:
Of 120 patients, 5.8% continued RRT after discharge. The 6-month mortality was 20%. Cox logistic regression analysis showed that urine IL-18 (P=0.021), plasma BNP (P=0.046), Acute Physiology and Chronic Health Evaluation (APACHE) II score (P=0.002), and left ventricular diastolic dysfunction (P=0.045) were independent predictors of the postdischarge requirement of RRT and/or 6-month mortality. For predicting RRT and/or 6-month mortality, using urine IL-18 cutoff value of 29.1 pg/mL showed 66.7% sensitivity and 67.7% specificity (area under the curve, AUC 0.70, P=0.003), while using plasma BNP cutoff value of 881.6 pg/mL showed 66.7% sensitivity and 70.8% specificity (AUC 0.76, P<0.001).
Conclusion:
Urine IL-18 and plasma BNP are independently predictive for the postdischarge requirement of RRT and/or 6-month mortality in patients with acute heart disorders.</description><issn>2345-2781</issn><issn>2345-2781</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpNkLtOw0AQRVcIJKKQkn5_wIn35UcJES8pEhKC2lrvTsgkjm3Ga5C_il_EJhRUM7q69xSHsWsRL4URqVjtCduljEW-NPqMzaTSJpJpJs7__Zds0XX7OI6FNLnQasa-X5oKeLPlWAegCvoD1pHIuK09byvbHS2_jcLQAq9tIOwJAjreQhvQwzjiLYFHF7B-5wQfPRIcoQ4T8YC-hmFMR447pWEHZNthoq8a4seGgq0wDBMIa4-f6HtbdfwLw45b1wfgO7AUuMeuIQ_UXbGL7diAxd-ds7f7u9f1Y7R5fnha32wiJ5UMkdGJsjaHJLXK6zKFxGmX69x45UvjpJZxNlZkVoIQFhKhdOa8NVnioFRGqTmLTlxHTdcRbIuW8GhpKERc_AovJuHFJLwwWv0AnCx5Dg</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Hamzić-Mehmedbašić, Aida</creator><creator>Rebić, Damir</creator><creator>Valjevac, Amina</creator><creator>Čubro, Hajrunisa</creator><creator>Durak Nalbantić, Azra</creator><creator>Herenda, Vedad</creator><creator>Kulo Ćesić, Aida</creator><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-4967-7616</orcidid></search><sort><creationdate>20191201</creationdate><title>Role of interleukin-18 and plasma B-type natriuretic peptide in predicting requirement of kidney replacement therapy and/or mortality in individuals with acute heart disorders</title><author>Hamzić-Mehmedbašić, Aida ; Rebić, Damir ; Valjevac, Amina ; Čubro, Hajrunisa ; Durak Nalbantić, Azra ; Herenda, Vedad ; Kulo Ćesić, Aida</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c232t-5463aa9e67a3d4b7e6c4c9495d3db5c2420846328be11ae61348cda586ceb3533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hamzić-Mehmedbašić, Aida</creatorcontrib><creatorcontrib>Rebić, Damir</creatorcontrib><creatorcontrib>Valjevac, Amina</creatorcontrib><creatorcontrib>Čubro, Hajrunisa</creatorcontrib><creatorcontrib>Durak Nalbantić, Azra</creatorcontrib><creatorcontrib>Herenda, Vedad</creatorcontrib><creatorcontrib>Kulo Ćesić, Aida</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of renal injury prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hamzić-Mehmedbašić, Aida</au><au>Rebić, Damir</au><au>Valjevac, Amina</au><au>Čubro, Hajrunisa</au><au>Durak Nalbantić, Azra</au><au>Herenda, Vedad</au><au>Kulo Ćesić, Aida</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of interleukin-18 and plasma B-type natriuretic peptide in predicting requirement of kidney replacement therapy and/or mortality in individuals with acute heart disorders</atitle><jtitle>Journal of renal injury prevention</jtitle><date>2019-12-01</date><risdate>2019</risdate><volume>8</volume><issue>4</issue><spage>292</spage><epage>300</epage><pages>292-300</pages><issn>2345-2781</issn><eissn>2345-2781</eissn><abstract>Introduction:
Although many predictive tools have already been developed, efforts are still proceeding to identify a reliable biomarker to predict the prognosis of the patients with acute heart disorders.
Objectives:
The aim was to evaluate the role of renal injury biomarkers (serum cystatin C, serum and urine interleukin-18, IL-18) and heart failure biomarkers (plasma B-type natriuretic peptide, BNP) in the prediction of the postdischarge requirement of renal replacement therapy (RRT) and/or 6-month mortality in patients with acute heart disorders.
Patients and Methods:
In patients diagnosed with acute heart disorders (acute heart failure [AHF] and/or acute coronary syndrome [ACS]) and admitted to the intensive care units, baseline clinical parameters, renal and cardiac biomarkers were determined. Patients were followed up for 6 months. The composite outcome was the postdischarge requirement of RRT and/or 6-month mortality.
Results:
Of 120 patients, 5.8% continued RRT after discharge. The 6-month mortality was 20%. Cox logistic regression analysis showed that urine IL-18 (P=0.021), plasma BNP (P=0.046), Acute Physiology and Chronic Health Evaluation (APACHE) II score (P=0.002), and left ventricular diastolic dysfunction (P=0.045) were independent predictors of the postdischarge requirement of RRT and/or 6-month mortality. For predicting RRT and/or 6-month mortality, using urine IL-18 cutoff value of 29.1 pg/mL showed 66.7% sensitivity and 67.7% specificity (area under the curve, AUC 0.70, P=0.003), while using plasma BNP cutoff value of 881.6 pg/mL showed 66.7% sensitivity and 70.8% specificity (AUC 0.76, P<0.001).
Conclusion:
Urine IL-18 and plasma BNP are independently predictive for the postdischarge requirement of RRT and/or 6-month mortality in patients with acute heart disorders.</abstract><doi>10.15171/jrip.2019.54</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-4967-7616</orcidid><oa>free_for_read</oa></addata></record> |
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title | Role of interleukin-18 and plasma B-type natriuretic peptide in predicting requirement of kidney replacement therapy and/or mortality in individuals with acute heart disorders |
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