2-Hexanoyl-1-tribromomethyl-1,2,3,4-tetrahydro-β-carboline: Crystal Structure Analysis of a Potent Inhibitor of Complex I of Mitochondrial Respiration
The molecular structure of the title compound 2-hexanoyl-1-tribromomethyl-1,2,3,4-tetra-hydro-β-carboline (3), a potent inhibitor of complex I of the mammalian mitochondrial respiratory chain, has been studied by single-crystal X-ray diffraction analysis. In the crystal, two heterochiral molecules o...
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| Veröffentlicht in: | Zeitschrift für Naturforschung. B, A journal of chemical sciences A journal of chemical sciences, 2000-01, Vol.55 (1), p.94-99 |
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| container_title | Zeitschrift für Naturforschung. B, A journal of chemical sciences |
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| creator | Bringmann, Gerhard Feineis, Doris Brückner, Ralph Peters, Eva-Maria Peters, Karl |
| description | The molecular structure of the title compound 2-hexanoyl-1-tribromomethyl-1,2,3,4-tetra-hydro-β-carboline (3), a potent inhibitor of complex I of the mammalian mitochondrial respiratory chain, has been studied by single-crystal X-ray diffraction analysis. In the crystal, two heterochiral molecules of 3 (i.e., one R- and one S-configured molecule each) were found to be connected with one other in pairs via two intermolecular hydrogen bonds [O(215) ··· H(212)′ and O(215)′ ··· H(212)] to form an overall achiral ‘dimeric’ subunit |
| doi_str_mv | 10.1515/znb-2000-0115 |
| format | Article |
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B, A journal of chemical sciences</title><description>The molecular structure of the title compound 2-hexanoyl-1-tribromomethyl-1,2,3,4-tetra-hydro-β-carboline (3), a potent inhibitor of complex I of the mammalian mitochondrial respiratory chain, has been studied by single-crystal X-ray diffraction analysis. In the crystal, two heterochiral molecules of 3 (i.e., one R- and one S-configured molecule each) were found to be connected with one other in pairs via two intermolecular hydrogen bonds [O(215) ··· H(212)′ and O(215)′ ··· H(212)] to form an overall achiral ‘dimeric’ subunit</description><subject>Bromal-Derived Tetrahydro-β-carbolines. 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| ispartof | Zeitschrift für Naturforschung. B, A journal of chemical sciences, 2000-01, Vol.55 (1), p.94-99 |
| issn | 0932-0776 1865-7117 |
| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | Bromal-Derived Tetrahydro-β-carbolines. Mitochondrial Respiration Crystal Structure Neurotoxicity Parkinson’s Disease |
| title | 2-Hexanoyl-1-tribromomethyl-1,2,3,4-tetrahydro-β-carboline: Crystal Structure Analysis of a Potent Inhibitor of Complex I of Mitochondrial Respiration |
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