Über die O-Trifluoracetylierung von Nucleosiden

Über die O-Trifluoracetylierung von Nucleosiden

The trifluoroacetylation of thymidine at room temperature was performed using trifluoroacetic acid phenylester in pyridine. A selective protection of the 5′-position was not possible: Even low molar quantities of the trifluoroacetylating agent gave rise to bis-trifluoroacetylation. The bis-trifluoro...

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Veröffentlicht in:Zeitschrift für Naturforschung. B, A journal of chemical sciences A journal of chemical sciences, 1967-03, Vol.22 (3), p.285-287
Hauptverfasser: Kresze, G., Lodemann, E., Wacker, A.
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container_issue 3
container_start_page 285
container_title Zeitschrift für Naturforschung. B, A journal of chemical sciences
container_volume 22
creator Kresze, G.
Lodemann, E.
Wacker, A.
description The trifluoroacetylation of thymidine at room temperature was performed using trifluoroacetic acid phenylester in pyridine. A selective protection of the 5′-position was not possible: Even low molar quantities of the trifluoroacetylating agent gave rise to bis-trifluoroacetylation. The bis-trifluoroacetyl derivatives of thymidine and 5-bromo-deoxyuridine were purified by vacuum sublimation. The completely trifluoroacetylated deoxyribosides of uracil, 5-iodouracil and adenine underwent decomposition during sublimation.
doi_str_mv 10.1515/znb-1967-0313
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title Über die O-Trifluoracetylierung von Nucleosiden
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