Über die Wirkung von Heparin, Heparinoiden und Carrageenin auf die Komponenten des Meerschweinchen-Komplements in vitro

The mode of action of six inhibitors of the complement system of guinea pig serum was analysed by use of the method described in the preceding paper. Carrageenin is the most powerful inhibitor followed by polyvinylalcoholsulfate, polyethenesulfate, heparinoid “Bayer”, dextransulfate, and heparin. All six substances are directed against C′ 1 and C′ 2. Heparin and polyethenesulfate also inhibit C′ 3b,β, while an effect of heparinoid “Bayer”, dextransulfate, and polyvinylalcoholsulfate upon C′ 3b,β could not definitely be demonstrated. It is not clear whether these latter substances act upon C′ 3b,β, C′ 3c,d, or upon both components. All substances tested exert the strongest inhibitory effect upon C′ 1 which thus becomes the limiting component in guinea pig complement.