Comparison of Total Tumor Volume, Size and Number of Colorectal Liver Metastases in Prediction of Survival in Patients after Liver Resection
Liver is the most common location of the colorectal cancer metastases occurrence. Liver resection is the only curative method of treatment. Unfortunately it is feasible only in 25% of patients with colorectal liver metastases, often because of the extensiveness of the disease. The aim of the study w...
Gespeichert in:
| Veröffentlicht in: | Polski przeglad chirurgiczny 2015-02, Vol.87 (2), p.53-58 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 58 |
|---|---|
| container_issue | 2 |
| container_start_page | 53 |
| container_title | Polski przeglad chirurgiczny |
| container_volume | 87 |
| creator | Hołówko, Wacław Grąt, Michał Wronka, Karolina Maria Stypułkowski, Jan Roszkowski, Rafał Studnicki, Paweł Krawczyk, Marek |
| description | Liver is the most common location of the colorectal cancer metastases occurrence. Liver resection is the only curative method of treatment. Unfortunately it is feasible only in 25% of patients with colorectal liver metastases, often because of the extensiveness of the disease.
The aim of the study was to evaluate the predictive value of total tumor volume, size and number of colorectal liver metastases in patients treated with right hemihepatectomy.
Material and methods. A retrospective analysis was performed in a group of 135 patients with colorectal liver metastases, who were treated with right hemihepatectomy. Total tumor volume was estimated based on the formula (4/3)πr3. Moreover, the study included an analysis of data on the number and size of tumors, radicality of the resection, time between primary tumor resection and liver resection, pre-operative blood serum concentration of carcinoembryonal antigen (CEA) and carcinoma antigen Ca19-9. The predictive value of the factors was evaluated by applying a Cox proportional hazards model and the area under the ROC curve.
Results. The univariate analysis has shown the predictive value of size of the largest tumor (p=0.033; HR=1.065 per each cm) on the overall survival, however no predictive value of number of tumors (p=0.997; HR=1.000) and total tumor volume (p=0.212; HR=1.002) was observed. The multivariate analysis did not confirm the predictive value of the size of the largest tumor (p=0.141; HR=1.056). In the analysis of ROC curves, AUROC for the total tumor volume, the size of the largest tumor and the number of tumors were 0.629, 0.608, 0.520, respectively.
Conclusions. Total tumor volume, size and number of liver metastases are not independent risk factors for the worse overall survival of patients with colorectal liver metastases treated with liver resection, therefore increased values of these factors should not be a contraindication for surgical treatment |
| doi_str_mv | 10.1515/pjs-2015-0019 |
| format | Article |
| fullrecord | <record><control><sourceid>walterdegruyter_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1515_pjs_2015_0019</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_1515_pjs_2015_001987253</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2593-665a72c91b1863128be89e2aeb4bb94ddafe567d29acf0d5d7cbe2ccb8bfbdb43</originalsourceid><addsrcrecordid>eNptkNlKxDAUhoMojtult5IHsJqkky7eyeAG44Izincly6lkaJshaUfGZ_ChTa2KF0Igh-Q7P_wfQoeUnFBO-ely4SNGKI8IofkG2iEkZlGcxi-bf-YR2vV-QQjPY5ZvoxFL6DghOd9BHxNbL4Uz3jbYlnhuW1HheVdbh59t1dVwjGfmHbBoNL7ragmuxya2sg5Uz07NKrzdQit8OOCxafCDA21Ua4bMWedWZhXQ_ke0BprWY1G2YW1YfgQPX_Q-2ipF5eHg-95DT5cX88l1NL2_upmcTyPFQoMoSbhImcqppFkSU5ZJyHJgAuRYynystSiBJ6lmuVAl0VynSgJTSmaylFqO4z0UDbnKWe8dlMXSmVq4dUFJ0VstgtWit1r0VgN_NPDLTtagf-kfjQE4G4A3UYVeGl5dtw5DsbCda0KV_4OzlPE4_gRIv4oJ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Comparison of Total Tumor Volume, Size and Number of Colorectal Liver Metastases in Prediction of Survival in Patients after Liver Resection</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Hołówko, Wacław ; Grąt, Michał ; Wronka, Karolina Maria ; Stypułkowski, Jan ; Roszkowski, Rafał ; Studnicki, Paweł ; Krawczyk, Marek</creator><creatorcontrib>Hołówko, Wacław ; Grąt, Michał ; Wronka, Karolina Maria ; Stypułkowski, Jan ; Roszkowski, Rafał ; Studnicki, Paweł ; Krawczyk, Marek</creatorcontrib><description>Liver is the most common location of the colorectal cancer metastases occurrence. Liver resection is the only curative method of treatment. Unfortunately it is feasible only in 25% of patients with colorectal liver metastases, often because of the extensiveness of the disease.
The aim of the study was to evaluate the predictive value of total tumor volume, size and number of colorectal liver metastases in patients treated with right hemihepatectomy.
Material and methods. A retrospective analysis was performed in a group of 135 patients with colorectal liver metastases, who were treated with right hemihepatectomy. Total tumor volume was estimated based on the formula (4/3)πr3. Moreover, the study included an analysis of data on the number and size of tumors, radicality of the resection, time between primary tumor resection and liver resection, pre-operative blood serum concentration of carcinoembryonal antigen (CEA) and carcinoma antigen Ca19-9. The predictive value of the factors was evaluated by applying a Cox proportional hazards model and the area under the ROC curve.
Results. The univariate analysis has shown the predictive value of size of the largest tumor (p=0.033; HR=1.065 per each cm) on the overall survival, however no predictive value of number of tumors (p=0.997; HR=1.000) and total tumor volume (p=0.212; HR=1.002) was observed. The multivariate analysis did not confirm the predictive value of the size of the largest tumor (p=0.141; HR=1.056). In the analysis of ROC curves, AUROC for the total tumor volume, the size of the largest tumor and the number of tumors were 0.629, 0.608, 0.520, respectively.
Conclusions. Total tumor volume, size and number of liver metastases are not independent risk factors for the worse overall survival of patients with colorectal liver metastases treated with liver resection, therefore increased values of these factors should not be a contraindication for surgical treatment</description><identifier>ISSN: 0032-373X</identifier><identifier>EISSN: 0032-373X</identifier><identifier>EISSN: 2299-2847</identifier><identifier>DOI: 10.1515/pjs-2015-0019</identifier><identifier>PMID: 26146095</identifier><language>eng</language><publisher>Poland: De Gruyter Open</publisher><subject>Age Factors ; Aged ; Carcinoembryonic Antigen - blood ; colorectal liver metastases ; Colorectal Neoplasms - blood ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Confidence Intervals ; Disease-Free Survival ; Female ; Follow-Up Studies ; Humans ; Liver Neoplasms - mortality ; Liver Neoplasms - secondary ; liver resection ; Male ; Poland ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; total tumor volume</subject><ispartof>Polski przeglad chirurgiczny, 2015-02, Vol.87 (2), p.53-58</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2593-665a72c91b1863128be89e2aeb4bb94ddafe567d29acf0d5d7cbe2ccb8bfbdb43</citedby><cites>FETCH-LOGICAL-c2593-665a72c91b1863128be89e2aeb4bb94ddafe567d29acf0d5d7cbe2ccb8bfbdb43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26146095$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hołówko, Wacław</creatorcontrib><creatorcontrib>Grąt, Michał</creatorcontrib><creatorcontrib>Wronka, Karolina Maria</creatorcontrib><creatorcontrib>Stypułkowski, Jan</creatorcontrib><creatorcontrib>Roszkowski, Rafał</creatorcontrib><creatorcontrib>Studnicki, Paweł</creatorcontrib><creatorcontrib>Krawczyk, Marek</creatorcontrib><title>Comparison of Total Tumor Volume, Size and Number of Colorectal Liver Metastases in Prediction of Survival in Patients after Liver Resection</title><title>Polski przeglad chirurgiczny</title><addtitle>Pol Przegl Chir</addtitle><description>Liver is the most common location of the colorectal cancer metastases occurrence. Liver resection is the only curative method of treatment. Unfortunately it is feasible only in 25% of patients with colorectal liver metastases, often because of the extensiveness of the disease.
The aim of the study was to evaluate the predictive value of total tumor volume, size and number of colorectal liver metastases in patients treated with right hemihepatectomy.
Material and methods. A retrospective analysis was performed in a group of 135 patients with colorectal liver metastases, who were treated with right hemihepatectomy. Total tumor volume was estimated based on the formula (4/3)πr3. Moreover, the study included an analysis of data on the number and size of tumors, radicality of the resection, time between primary tumor resection and liver resection, pre-operative blood serum concentration of carcinoembryonal antigen (CEA) and carcinoma antigen Ca19-9. The predictive value of the factors was evaluated by applying a Cox proportional hazards model and the area under the ROC curve.
Results. The univariate analysis has shown the predictive value of size of the largest tumor (p=0.033; HR=1.065 per each cm) on the overall survival, however no predictive value of number of tumors (p=0.997; HR=1.000) and total tumor volume (p=0.212; HR=1.002) was observed. The multivariate analysis did not confirm the predictive value of the size of the largest tumor (p=0.141; HR=1.056). In the analysis of ROC curves, AUROC for the total tumor volume, the size of the largest tumor and the number of tumors were 0.629, 0.608, 0.520, respectively.
Conclusions. Total tumor volume, size and number of liver metastases are not independent risk factors for the worse overall survival of patients with colorectal liver metastases treated with liver resection, therefore increased values of these factors should not be a contraindication for surgical treatment</description><subject>Age Factors</subject><subject>Aged</subject><subject>Carcinoembryonic Antigen - blood</subject><subject>colorectal liver metastases</subject><subject>Colorectal Neoplasms - blood</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Confidence Intervals</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - secondary</subject><subject>liver resection</subject><subject>Male</subject><subject>Poland</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Retrospective Studies</subject><subject>total tumor volume</subject><issn>0032-373X</issn><issn>0032-373X</issn><issn>2299-2847</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkNlKxDAUhoMojtult5IHsJqkky7eyeAG44Izincly6lkaJshaUfGZ_ChTa2KF0Igh-Q7P_wfQoeUnFBO-ely4SNGKI8IofkG2iEkZlGcxi-bf-YR2vV-QQjPY5ZvoxFL6DghOd9BHxNbL4Uz3jbYlnhuW1HheVdbh59t1dVwjGfmHbBoNL7ragmuxya2sg5Uz07NKrzdQit8OOCxafCDA21Ua4bMWedWZhXQ_ke0BprWY1G2YW1YfgQPX_Q-2ipF5eHg-95DT5cX88l1NL2_upmcTyPFQoMoSbhImcqppFkSU5ZJyHJgAuRYynystSiBJ6lmuVAl0VynSgJTSmaylFqO4z0UDbnKWe8dlMXSmVq4dUFJ0VstgtWit1r0VgN_NPDLTtagf-kfjQE4G4A3UYVeGl5dtw5DsbCda0KV_4OzlPE4_gRIv4oJ</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Hołówko, Wacław</creator><creator>Grąt, Michał</creator><creator>Wronka, Karolina Maria</creator><creator>Stypułkowski, Jan</creator><creator>Roszkowski, Rafał</creator><creator>Studnicki, Paweł</creator><creator>Krawczyk, Marek</creator><general>De Gruyter Open</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20150201</creationdate><title>Comparison of Total Tumor Volume, Size and Number of Colorectal Liver Metastases in Prediction of Survival in Patients after Liver Resection</title><author>Hołówko, Wacław ; Grąt, Michał ; Wronka, Karolina Maria ; Stypułkowski, Jan ; Roszkowski, Rafał ; Studnicki, Paweł ; Krawczyk, Marek</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2593-665a72c91b1863128be89e2aeb4bb94ddafe567d29acf0d5d7cbe2ccb8bfbdb43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Carcinoembryonic Antigen - blood</topic><topic>colorectal liver metastases</topic><topic>Colorectal Neoplasms - blood</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Confidence Intervals</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - secondary</topic><topic>liver resection</topic><topic>Male</topic><topic>Poland</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Retrospective Studies</topic><topic>total tumor volume</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hołówko, Wacław</creatorcontrib><creatorcontrib>Grąt, Michał</creatorcontrib><creatorcontrib>Wronka, Karolina Maria</creatorcontrib><creatorcontrib>Stypułkowski, Jan</creatorcontrib><creatorcontrib>Roszkowski, Rafał</creatorcontrib><creatorcontrib>Studnicki, Paweł</creatorcontrib><creatorcontrib>Krawczyk, Marek</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Polski przeglad chirurgiczny</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hołówko, Wacław</au><au>Grąt, Michał</au><au>Wronka, Karolina Maria</au><au>Stypułkowski, Jan</au><au>Roszkowski, Rafał</au><au>Studnicki, Paweł</au><au>Krawczyk, Marek</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Total Tumor Volume, Size and Number of Colorectal Liver Metastases in Prediction of Survival in Patients after Liver Resection</atitle><jtitle>Polski przeglad chirurgiczny</jtitle><addtitle>Pol Przegl Chir</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>87</volume><issue>2</issue><spage>53</spage><epage>58</epage><pages>53-58</pages><issn>0032-373X</issn><eissn>0032-373X</eissn><eissn>2299-2847</eissn><abstract>Liver is the most common location of the colorectal cancer metastases occurrence. Liver resection is the only curative method of treatment. Unfortunately it is feasible only in 25% of patients with colorectal liver metastases, often because of the extensiveness of the disease.
The aim of the study was to evaluate the predictive value of total tumor volume, size and number of colorectal liver metastases in patients treated with right hemihepatectomy.
Material and methods. A retrospective analysis was performed in a group of 135 patients with colorectal liver metastases, who were treated with right hemihepatectomy. Total tumor volume was estimated based on the formula (4/3)πr3. Moreover, the study included an analysis of data on the number and size of tumors, radicality of the resection, time between primary tumor resection and liver resection, pre-operative blood serum concentration of carcinoembryonal antigen (CEA) and carcinoma antigen Ca19-9. The predictive value of the factors was evaluated by applying a Cox proportional hazards model and the area under the ROC curve.
Results. The univariate analysis has shown the predictive value of size of the largest tumor (p=0.033; HR=1.065 per each cm) on the overall survival, however no predictive value of number of tumors (p=0.997; HR=1.000) and total tumor volume (p=0.212; HR=1.002) was observed. The multivariate analysis did not confirm the predictive value of the size of the largest tumor (p=0.141; HR=1.056). In the analysis of ROC curves, AUROC for the total tumor volume, the size of the largest tumor and the number of tumors were 0.629, 0.608, 0.520, respectively.
Conclusions. Total tumor volume, size and number of liver metastases are not independent risk factors for the worse overall survival of patients with colorectal liver metastases treated with liver resection, therefore increased values of these factors should not be a contraindication for surgical treatment</abstract><cop>Poland</cop><pub>De Gruyter Open</pub><pmid>26146095</pmid><doi>10.1515/pjs-2015-0019</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0032-373X |
| ispartof | Polski przeglad chirurgiczny, 2015-02, Vol.87 (2), p.53-58 |
| issn | 0032-373X 0032-373X 2299-2847 |
| language | eng |
| recordid | cdi_crossref_primary_10_1515_pjs_2015_0019 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Age Factors Aged Carcinoembryonic Antigen - blood colorectal liver metastases Colorectal Neoplasms - blood Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Confidence Intervals Disease-Free Survival Female Follow-Up Studies Humans Liver Neoplasms - mortality Liver Neoplasms - secondary liver resection Male Poland Prognosis Proportional Hazards Models Retrospective Studies total tumor volume |
| title | Comparison of Total Tumor Volume, Size and Number of Colorectal Liver Metastases in Prediction of Survival in Patients after Liver Resection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T10%3A17%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-walterdegruyter_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20Total%20Tumor%20Volume,%20Size%20and%20Number%20of%20Colorectal%20Liver%20Metastases%20in%20Prediction%20of%20Survival%20in%20Patients%20after%20Liver%20Resection&rft.jtitle=Polski%20przeglad%20chirurgiczny&rft.au=Ho%C5%82%C3%B3wko,%20Wac%C5%82aw&rft.date=2015-02-01&rft.volume=87&rft.issue=2&rft.spage=53&rft.epage=58&rft.pages=53-58&rft.issn=0032-373X&rft.eissn=0032-373X&rft_id=info:doi/10.1515/pjs-2015-0019&rft_dat=%3Cwalterdegruyter_cross%3E10_1515_pjs_2015_001987253%3C/walterdegruyter_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/26146095&rfr_iscdi=true |