Preparation of optically active 4-substituted γ-lactones by lipase-catalyzed optical resolution

Optically active 4-substituted γ-lactones ( and ) were synthesized effectively using lipase-catalyzed optical resolution. -methyl-4-hydroxyalkanamides ( ) as substrates were prepared from -methylsuccinimide. The alkylation of -methylsuccinimide using Grignard reagents generated from various alkyl ha...

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Veröffentlicht in:	Heterocyclic communications 2015-06, Vol.21 (3), p.165-174
Hauptverfasser:	Shimotori, Yasutaka, Hoshi, Masayuki, Inoue, Keita, Osanai, Takeshi, Okabe, Hayato, Miyakoshi, Tetsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	enantioselective acetylation enzymatic resolution Grignard reaction organolithium reagent γ-lactone
Online-Zugang:	Volltext
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