Study on Changes of the Urea, Serum Creatinine and Glomerular Protein Permeability, after General Anesthesia with Sevoflurane
: The widespread use of sevoflurane as an induction and maintenance volatile agent of general anesthesia demostrates an increased safety profile. Sevoflurane contact with CO absorbents lead to the occurrence of toxic compounds such as Compund A and Compound B. Among the side efffects of Sevoflurane...
Gespeichert in:
| Veröffentlicht in: | Acta Medica Marisiensis 2015-09, Vol.61 (3), p.176-179 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 179 |
|---|---|
| container_issue | 3 |
| container_start_page | 176 |
| container_title | Acta Medica Marisiensis |
| container_volume | 61 |
| creator | Mircea, Stoian Adina, Stoian Dumitru, Costel Florin, Tripon Iudita, Badea Leonard, Azamfirei |
| description | : The widespread use of sevoflurane as an induction and maintenance volatile agent of general anesthesia demostrates an increased safety profile. Sevoflurane contact with CO
absorbents lead to the occurrence of toxic compounds such as Compund A and Compound B. Among the side efffects of Sevoflurane remember the renal toxic effect much discussed in the literature but still unresolved. In previous research we have demonstrated the glomerular protein changes as a result of exposure to Sevoflurane. In the current study we intend to monitor the changes in blood urea nitrogen and serum creatinine after exposure to Sevoflurane.
We included in our study 90 patients who were anesthetized in the Department of Anesthesiology of the County Mure Hospital during 01.10.2009-01.10.2014. They had normal values for blood urea nitrogen and serum creatinine and had no preoperative proteinuria. Serum and urine samples were taken preoperatively and at 24 and 72 hours postanesthetic and were analyzed in the laboratory. Proteinuria was determined by spectrophotometry.
After protein quantitative determination by spectrophotometry and statistical anaysis we obtained significant differences by comparing the average preoperative/24 hours total protein (p |
| doi_str_mv | 10.1515/amma-2015-0053 |
| format | Article |
| fullrecord | <record><control><sourceid>walterdegruyter_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1515_amma_2015_0053</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_1515_amma_2015_0053613176</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1326-417a67edb9ae6a7a7482ed731acf2e2d6a0d3502efa779fdefcf3d384c609bd53</originalsourceid><addsrcrecordid>eNp1kE1Lw0AQhoMoWLRXz_sDmrofyW4LXkrRKhQs1J7DNDvbbkk2sptYcvC_u6EevHial4HnZeZJkgdGpyxn-SPUNaScsjylNBdXyYjzTKWSMXH9J98m4xBOlFKmxIxROUq-t22ne9I4sjyCO2AgjSHtEcnOI0zIFn1Xk2XMrXXWIQGnyapq6rivwJONb1q0jmzQ1wh7W9m2nxAwLXqyQoceKrJwGGJjsEDOtj3Gzq_GVJ0Hh_fJjYEq4Ph33iW7l-eP5Wu6fl-9LRfrtGSCyzRjCqRCvZ8DSlCgshlHrQSD0nDkWgLVIqccDSg1NxpNaYQWs6yUdL7XubhLppfe0jcheDTFp7c1-L5gtBj8FYO_YvBXDP4i8HQBzlDFXzQefNfHUJyazrt46j-gZIIpKX4AYOJ54g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Study on Changes of the Urea, Serum Creatinine and Glomerular Protein Permeability, after General Anesthesia with Sevoflurane</title><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Mircea, Stoian ; Adina, Stoian ; Dumitru, Costel ; Florin, Tripon ; Iudita, Badea ; Leonard, Azamfirei</creator><creatorcontrib>Mircea, Stoian ; Adina, Stoian ; Dumitru, Costel ; Florin, Tripon ; Iudita, Badea ; Leonard, Azamfirei</creatorcontrib><description>: The widespread use of sevoflurane as an induction and maintenance volatile agent of general anesthesia demostrates an increased safety profile. Sevoflurane contact with CO
absorbents lead to the occurrence of toxic compounds such as Compund A and Compound B. Among the side efffects of Sevoflurane remember the renal toxic effect much discussed in the literature but still unresolved. In previous research we have demonstrated the glomerular protein changes as a result of exposure to Sevoflurane. In the current study we intend to monitor the changes in blood urea nitrogen and serum creatinine after exposure to Sevoflurane.
We included in our study 90 patients who were anesthetized in the Department of Anesthesiology of the County Mure Hospital during 01.10.2009-01.10.2014. They had normal values for blood urea nitrogen and serum creatinine and had no preoperative proteinuria. Serum and urine samples were taken preoperatively and at 24 and 72 hours postanesthetic and were analyzed in the laboratory. Proteinuria was determined by spectrophotometry.
After protein quantitative determination by spectrophotometry and statistical anaysis we obtained significant differences by comparing the average preoperative/24 hours total protein (p<0.0001) and 24/72 hours (p<0.0001). There are no significant statistical differences by comparing the blood urea nitrogen at the three intervals (p<0.53) and no statistical changes for mean serum creatinine (p<0.18).
Changes in glomerular filtered proteins following exposure to Sevoflurane demonstrate its toxic effect on glomerular tubules. Lack of perioperative significant wich is why we recommend determining perioperative urinary protein as a marker of glomerular damage.</description><identifier>ISSN: 2247-6113</identifier><identifier>EISSN: 2247-6113</identifier><identifier>DOI: 10.1515/amma-2015-0053</identifier><language>eng</language><publisher>De Gruyter Open</publisher><subject>blood urea nitrogen ; creatinine ; proteinuria ; Sevoflurane</subject><ispartof>Acta Medica Marisiensis, 2015-09, Vol.61 (3), p.176-179</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Mircea, Stoian</creatorcontrib><creatorcontrib>Adina, Stoian</creatorcontrib><creatorcontrib>Dumitru, Costel</creatorcontrib><creatorcontrib>Florin, Tripon</creatorcontrib><creatorcontrib>Iudita, Badea</creatorcontrib><creatorcontrib>Leonard, Azamfirei</creatorcontrib><title>Study on Changes of the Urea, Serum Creatinine and Glomerular Protein Permeability, after General Anesthesia with Sevoflurane</title><title>Acta Medica Marisiensis</title><description>: The widespread use of sevoflurane as an induction and maintenance volatile agent of general anesthesia demostrates an increased safety profile. Sevoflurane contact with CO
absorbents lead to the occurrence of toxic compounds such as Compund A and Compound B. Among the side efffects of Sevoflurane remember the renal toxic effect much discussed in the literature but still unresolved. In previous research we have demonstrated the glomerular protein changes as a result of exposure to Sevoflurane. In the current study we intend to monitor the changes in blood urea nitrogen and serum creatinine after exposure to Sevoflurane.
We included in our study 90 patients who were anesthetized in the Department of Anesthesiology of the County Mure Hospital during 01.10.2009-01.10.2014. They had normal values for blood urea nitrogen and serum creatinine and had no preoperative proteinuria. Serum and urine samples were taken preoperatively and at 24 and 72 hours postanesthetic and were analyzed in the laboratory. Proteinuria was determined by spectrophotometry.
After protein quantitative determination by spectrophotometry and statistical anaysis we obtained significant differences by comparing the average preoperative/24 hours total protein (p<0.0001) and 24/72 hours (p<0.0001). There are no significant statistical differences by comparing the blood urea nitrogen at the three intervals (p<0.53) and no statistical changes for mean serum creatinine (p<0.18).
Changes in glomerular filtered proteins following exposure to Sevoflurane demonstrate its toxic effect on glomerular tubules. Lack of perioperative significant wich is why we recommend determining perioperative urinary protein as a marker of glomerular damage.</description><subject>blood urea nitrogen</subject><subject>creatinine</subject><subject>proteinuria</subject><subject>Sevoflurane</subject><issn>2247-6113</issn><issn>2247-6113</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp1kE1Lw0AQhoMoWLRXz_sDmrofyW4LXkrRKhQs1J7DNDvbbkk2sptYcvC_u6EevHial4HnZeZJkgdGpyxn-SPUNaScsjylNBdXyYjzTKWSMXH9J98m4xBOlFKmxIxROUq-t22ne9I4sjyCO2AgjSHtEcnOI0zIFn1Xk2XMrXXWIQGnyapq6rivwJONb1q0jmzQ1wh7W9m2nxAwLXqyQoceKrJwGGJjsEDOtj3Gzq_GVJ0Hh_fJjYEq4Ph33iW7l-eP5Wu6fl-9LRfrtGSCyzRjCqRCvZ8DSlCgshlHrQSD0nDkWgLVIqccDSg1NxpNaYQWs6yUdL7XubhLppfe0jcheDTFp7c1-L5gtBj8FYO_YvBXDP4i8HQBzlDFXzQefNfHUJyazrt46j-gZIIpKX4AYOJ54g</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Mircea, Stoian</creator><creator>Adina, Stoian</creator><creator>Dumitru, Costel</creator><creator>Florin, Tripon</creator><creator>Iudita, Badea</creator><creator>Leonard, Azamfirei</creator><general>De Gruyter Open</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20150901</creationdate><title>Study on Changes of the Urea, Serum Creatinine and Glomerular Protein Permeability, after General Anesthesia with Sevoflurane</title><author>Mircea, Stoian ; Adina, Stoian ; Dumitru, Costel ; Florin, Tripon ; Iudita, Badea ; Leonard, Azamfirei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1326-417a67edb9ae6a7a7482ed731acf2e2d6a0d3502efa779fdefcf3d384c609bd53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>blood urea nitrogen</topic><topic>creatinine</topic><topic>proteinuria</topic><topic>Sevoflurane</topic><toplevel>online_resources</toplevel><creatorcontrib>Mircea, Stoian</creatorcontrib><creatorcontrib>Adina, Stoian</creatorcontrib><creatorcontrib>Dumitru, Costel</creatorcontrib><creatorcontrib>Florin, Tripon</creatorcontrib><creatorcontrib>Iudita, Badea</creatorcontrib><creatorcontrib>Leonard, Azamfirei</creatorcontrib><collection>CrossRef</collection><jtitle>Acta Medica Marisiensis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mircea, Stoian</au><au>Adina, Stoian</au><au>Dumitru, Costel</au><au>Florin, Tripon</au><au>Iudita, Badea</au><au>Leonard, Azamfirei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study on Changes of the Urea, Serum Creatinine and Glomerular Protein Permeability, after General Anesthesia with Sevoflurane</atitle><jtitle>Acta Medica Marisiensis</jtitle><date>2015-09-01</date><risdate>2015</risdate><volume>61</volume><issue>3</issue><spage>176</spage><epage>179</epage><pages>176-179</pages><issn>2247-6113</issn><eissn>2247-6113</eissn><abstract>: The widespread use of sevoflurane as an induction and maintenance volatile agent of general anesthesia demostrates an increased safety profile. Sevoflurane contact with CO
absorbents lead to the occurrence of toxic compounds such as Compund A and Compound B. Among the side efffects of Sevoflurane remember the renal toxic effect much discussed in the literature but still unresolved. In previous research we have demonstrated the glomerular protein changes as a result of exposure to Sevoflurane. In the current study we intend to monitor the changes in blood urea nitrogen and serum creatinine after exposure to Sevoflurane.
We included in our study 90 patients who were anesthetized in the Department of Anesthesiology of the County Mure Hospital during 01.10.2009-01.10.2014. They had normal values for blood urea nitrogen and serum creatinine and had no preoperative proteinuria. Serum and urine samples were taken preoperatively and at 24 and 72 hours postanesthetic and were analyzed in the laboratory. Proteinuria was determined by spectrophotometry.
After protein quantitative determination by spectrophotometry and statistical anaysis we obtained significant differences by comparing the average preoperative/24 hours total protein (p<0.0001) and 24/72 hours (p<0.0001). There are no significant statistical differences by comparing the blood urea nitrogen at the three intervals (p<0.53) and no statistical changes for mean serum creatinine (p<0.18).
Changes in glomerular filtered proteins following exposure to Sevoflurane demonstrate its toxic effect on glomerular tubules. Lack of perioperative significant wich is why we recommend determining perioperative urinary protein as a marker of glomerular damage.</abstract><pub>De Gruyter Open</pub><doi>10.1515/amma-2015-0053</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2247-6113 |
| ispartof | Acta Medica Marisiensis, 2015-09, Vol.61 (3), p.176-179 |
| issn | 2247-6113 2247-6113 |
| language | eng |
| recordid | cdi_crossref_primary_10_1515_amma_2015_0053 |
| source | EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | blood urea nitrogen creatinine proteinuria Sevoflurane |
| title | Study on Changes of the Urea, Serum Creatinine and Glomerular Protein Permeability, after General Anesthesia with Sevoflurane |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T14%3A43%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-walterdegruyter_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Study%20on%20Changes%20of%20the%20Urea,%20Serum%20Creatinine%20and%20Glomerular%20Protein%20Permeability,%20after%20General%20Anesthesia%20with%20Sevoflurane&rft.jtitle=Acta%20Medica%20Marisiensis&rft.au=Mircea,%20Stoian&rft.date=2015-09-01&rft.volume=61&rft.issue=3&rft.spage=176&rft.epage=179&rft.pages=176-179&rft.issn=2247-6113&rft.eissn=2247-6113&rft_id=info:doi/10.1515/amma-2015-0053&rft_dat=%3Cwalterdegruyter_cross%3E10_1515_amma_2015_0053613176%3C/walterdegruyter_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |