Alterations of the preoperative coagulation profile in patients with acute appendicitis
Background: Acute appendicitis (AA) is usually associated with a systemic inflammatory response that often leads to activation of coagulation. However, limited data about coagulation changes in AA are available. Methods: Results of preoperative coagulation testing in 702 patients with confirmed AA a...
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| Veröffentlicht in: | Clinical chemistry and laboratory medicine 2011-08, Vol.49 (8), p.1333-1339 |
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| container_title | Clinical chemistry and laboratory medicine |
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| creator | Li, Jianxin Liu, Yan Yin, Weihua Zhang, Chuanzhou Huang, Jinhe Liao, Chaoyu Nie, Liping Zhou, Yu Xiao, Ping |
| description | Background: Acute appendicitis (AA) is usually associated with a systemic inflammatory response that often leads to activation of coagulation. However, limited data about coagulation changes in AA are available. Methods: Results of preoperative coagulation testing in 702 patients with confirmed AA and 697 patients undergoing minor elective surgery (control) during the same period were analyzed retrospectively. Coagulation activity of factors VII, IX (FVII:C, FIX:C) and the concentration of plasma endotoxin from 40 patients with AA and 15 control subjects were measured. Results: Compared with control subjects, prothrombin time (PT), fibrinogen (Fib) and endotoxin increased (all p |
| doi_str_mv | 10.1515/CCLM.2011.214 |
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| fullrecord | <record><control><sourceid>walterdegruyter_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1515_CCLM_2011_214</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_1515_CCLM_2011_2144981333</sourcerecordid><originalsourceid>FETCH-LOGICAL-c457t-5b87b98bd25308655b554b6ef4016102c967c0c3a93fe5f2e6a2cf3ff587fd853</originalsourceid><addsrcrecordid>eNptkM1LwzAYh4Mozq-jV-nFY2fSfLQDL7OoEyaiKIKXkKaJZnZtSVLn_nvTbc6LueTlzcP7_vIAcIrgEFFEL_J8ej9MIELDBJEdcIAITmOCMdpd1SRmLEEDcOjcDEJEKUn3wSBBjGHK0gPwOq68ssKbpnZRoyP_oaLWqqZdNb9UJBvx3lUrIDw02lQqMqEMHVV7Fy2M_4iE7LyKRNuqujTSeOOOwZ4WlVMnm_sIvNxcP-eTePpwe5ePp7EkNPUxLbK0GGVFmVAMM0ZpERIWTGkCEUMwkSOWSiixGGGtqE4UE4nUWGuapbrMKD4C8XqutI1zVmneWjMXdskR5L0g3gvivSAeBAX-bM23XTFX5Zb-NRKA8w0gnBSVtqKWxv1xhNCQrV98ueYWojdYqnfbLUPBZ01n6_Dl_wOQUYZwONvcxnn1vR0v7CcPIVLKH58Jn2STN3T1lHGKfwDb05EE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Alterations of the preoperative coagulation profile in patients with acute appendicitis</title><source>MEDLINE</source><source>De Gruyter journals</source><creator>Li, Jianxin ; Liu, Yan ; Yin, Weihua ; Zhang, Chuanzhou ; Huang, Jinhe ; Liao, Chaoyu ; Nie, Liping ; Zhou, Yu ; Xiao, Ping</creator><creatorcontrib>Li, Jianxin ; Liu, Yan ; Yin, Weihua ; Zhang, Chuanzhou ; Huang, Jinhe ; Liao, Chaoyu ; Nie, Liping ; Zhou, Yu ; Xiao, Ping</creatorcontrib><description><![CDATA[Background: Acute appendicitis (AA) is usually associated with a systemic inflammatory response that often leads to activation of coagulation. However, limited data about coagulation changes in AA are available. Methods: Results of preoperative coagulation testing in 702 patients with confirmed AA and 697 patients undergoing minor elective surgery (control) during the same period were analyzed retrospectively. Coagulation activity of factors VII, IX (FVII:C, FIX:C) and the concentration of plasma endotoxin from 40 patients with AA and 15 control subjects were measured. Results: Compared with control subjects, prothrombin time (PT), fibrinogen (Fib) and endotoxin increased (all p<0.01), FVII:C decreased (p<0.05), and thrombin time shortened (p<0.01) significantly in patients with AA, which showed trends with increasing severity of disease. Areas under the receiver operating characteristic curve of Fib for discriminating complicated appendicitis or acute perforated appendicitis from enrolled patients were larger than those for leukocyte parameters. The concentration of endotoxin correlated negatively with FVII:C (r=−0.860, p<0.001), positively with PT (0.713, <0.001), and FVII:C negatively with PT (−0.729, <0.001) in individuals that were evaluated. The change in activated partial thromboplastin time and difference in FIX:C among patients with various pathological types of appendicitis were not significant. Conclusions: Endotoxin-induced activation of the extrinsic coagulation pathway was present in patients with AA. Fib may be useful as a potential indicator for excluding complicated appendicitis.]]></description><identifier>ISSN: 1434-6621</identifier><identifier>EISSN: 1437-4331</identifier><identifier>DOI: 10.1515/CCLM.2011.214</identifier><identifier>PMID: 21663567</identifier><language>eng</language><publisher>Berlin: Walter de Gruyter</publisher><subject>acute appendicitis ; Acute Disease ; Adult ; Appendicitis - blood ; Appendicitis - complications ; Area Under Curve ; Bacteremia - complications ; Biological and medical sciences ; Blood Coagulation Tests ; coagulation factor ; coagulation screening tests ; endotoxin ; Endotoxins - blood ; Factor VII - metabolism ; Factor X - metabolism ; Female ; Fibrinogen - analysis ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; leukocyte parameters ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Preoperative Period ; Prothrombin Time ; Retrospective Studies ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><ispartof>Clinical chemistry and laboratory medicine, 2011-08, Vol.49 (8), p.1333-1339</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-5b87b98bd25308655b554b6ef4016102c967c0c3a93fe5f2e6a2cf3ff587fd853</citedby><cites>FETCH-LOGICAL-c457t-5b87b98bd25308655b554b6ef4016102c967c0c3a93fe5f2e6a2cf3ff587fd853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.degruyter.com/document/doi/10.1515/CCLM.2011.214/pdf$$EPDF$$P50$$Gwalterdegruyter$$H</linktopdf><linktohtml>$$Uhttps://www.degruyter.com/document/doi/10.1515/CCLM.2011.214/html$$EHTML$$P50$$Gwalterdegruyter$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,66500,68284</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24454015$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21663567$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Jianxin</creatorcontrib><creatorcontrib>Liu, Yan</creatorcontrib><creatorcontrib>Yin, Weihua</creatorcontrib><creatorcontrib>Zhang, Chuanzhou</creatorcontrib><creatorcontrib>Huang, Jinhe</creatorcontrib><creatorcontrib>Liao, Chaoyu</creatorcontrib><creatorcontrib>Nie, Liping</creatorcontrib><creatorcontrib>Zhou, Yu</creatorcontrib><creatorcontrib>Xiao, Ping</creatorcontrib><title>Alterations of the preoperative coagulation profile in patients with acute appendicitis</title><title>Clinical chemistry and laboratory medicine</title><addtitle>Clin Chem Lab Med</addtitle><description><![CDATA[Background: Acute appendicitis (AA) is usually associated with a systemic inflammatory response that often leads to activation of coagulation. However, limited data about coagulation changes in AA are available. Methods: Results of preoperative coagulation testing in 702 patients with confirmed AA and 697 patients undergoing minor elective surgery (control) during the same period were analyzed retrospectively. Coagulation activity of factors VII, IX (FVII:C, FIX:C) and the concentration of plasma endotoxin from 40 patients with AA and 15 control subjects were measured. Results: Compared with control subjects, prothrombin time (PT), fibrinogen (Fib) and endotoxin increased (all p<0.01), FVII:C decreased (p<0.05), and thrombin time shortened (p<0.01) significantly in patients with AA, which showed trends with increasing severity of disease. Areas under the receiver operating characteristic curve of Fib for discriminating complicated appendicitis or acute perforated appendicitis from enrolled patients were larger than those for leukocyte parameters. The concentration of endotoxin correlated negatively with FVII:C (r=−0.860, p<0.001), positively with PT (0.713, <0.001), and FVII:C negatively with PT (−0.729, <0.001) in individuals that were evaluated. The change in activated partial thromboplastin time and difference in FIX:C among patients with various pathological types of appendicitis were not significant. Conclusions: Endotoxin-induced activation of the extrinsic coagulation pathway was present in patients with AA. Fib may be useful as a potential indicator for excluding complicated appendicitis.]]></description><subject>acute appendicitis</subject><subject>Acute Disease</subject><subject>Adult</subject><subject>Appendicitis - blood</subject><subject>Appendicitis - complications</subject><subject>Area Under Curve</subject><subject>Bacteremia - complications</subject><subject>Biological and medical sciences</subject><subject>Blood Coagulation Tests</subject><subject>coagulation factor</subject><subject>coagulation screening tests</subject><subject>endotoxin</subject><subject>Endotoxins - blood</subject><subject>Factor VII - metabolism</subject><subject>Factor X - metabolism</subject><subject>Female</subject><subject>Fibrinogen - analysis</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>General aspects</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>leukocyte parameters</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Preoperative Period</subject><subject>Prothrombin Time</subject><subject>Retrospective Studies</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><issn>1434-6621</issn><issn>1437-4331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM1LwzAYh4Mozq-jV-nFY2fSfLQDL7OoEyaiKIKXkKaJZnZtSVLn_nvTbc6LueTlzcP7_vIAcIrgEFFEL_J8ej9MIELDBJEdcIAITmOCMdpd1SRmLEEDcOjcDEJEKUn3wSBBjGHK0gPwOq68ssKbpnZRoyP_oaLWqqZdNb9UJBvx3lUrIDw02lQqMqEMHVV7Fy2M_4iE7LyKRNuqujTSeOOOwZ4WlVMnm_sIvNxcP-eTePpwe5ePp7EkNPUxLbK0GGVFmVAMM0ZpERIWTGkCEUMwkSOWSiixGGGtqE4UE4nUWGuapbrMKD4C8XqutI1zVmneWjMXdskR5L0g3gvivSAeBAX-bM23XTFX5Zb-NRKA8w0gnBSVtqKWxv1xhNCQrV98ueYWojdYqnfbLUPBZ01n6_Dl_wOQUYZwONvcxnn1vR0v7CcPIVLKH58Jn2STN3T1lHGKfwDb05EE</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Li, Jianxin</creator><creator>Liu, Yan</creator><creator>Yin, Weihua</creator><creator>Zhang, Chuanzhou</creator><creator>Huang, Jinhe</creator><creator>Liao, Chaoyu</creator><creator>Nie, Liping</creator><creator>Zhou, Yu</creator><creator>Xiao, Ping</creator><general>Walter de Gruyter</general><general>De Gruyter</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20110801</creationdate><title>Alterations of the preoperative coagulation profile in patients with acute appendicitis</title><author>Li, Jianxin ; Liu, Yan ; Yin, Weihua ; Zhang, Chuanzhou ; Huang, Jinhe ; Liao, Chaoyu ; Nie, Liping ; Zhou, Yu ; Xiao, Ping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-5b87b98bd25308655b554b6ef4016102c967c0c3a93fe5f2e6a2cf3ff587fd853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>acute appendicitis</topic><topic>Acute Disease</topic><topic>Adult</topic><topic>Appendicitis - blood</topic><topic>Appendicitis - complications</topic><topic>Area Under Curve</topic><topic>Bacteremia - complications</topic><topic>Biological and medical sciences</topic><topic>Blood Coagulation Tests</topic><topic>coagulation factor</topic><topic>coagulation screening tests</topic><topic>endotoxin</topic><topic>Endotoxins - blood</topic><topic>Factor VII - metabolism</topic><topic>Factor X - metabolism</topic><topic>Female</topic><topic>Fibrinogen - analysis</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>General aspects</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>leukocyte parameters</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Preoperative Period</topic><topic>Prothrombin Time</topic><topic>Retrospective Studies</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Jianxin</creatorcontrib><creatorcontrib>Liu, Yan</creatorcontrib><creatorcontrib>Yin, Weihua</creatorcontrib><creatorcontrib>Zhang, Chuanzhou</creatorcontrib><creatorcontrib>Huang, Jinhe</creatorcontrib><creatorcontrib>Liao, Chaoyu</creatorcontrib><creatorcontrib>Nie, Liping</creatorcontrib><creatorcontrib>Zhou, Yu</creatorcontrib><creatorcontrib>Xiao, Ping</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Clinical chemistry and laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Jianxin</au><au>Liu, Yan</au><au>Yin, Weihua</au><au>Zhang, Chuanzhou</au><au>Huang, Jinhe</au><au>Liao, Chaoyu</au><au>Nie, Liping</au><au>Zhou, Yu</au><au>Xiao, Ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alterations of the preoperative coagulation profile in patients with acute appendicitis</atitle><jtitle>Clinical chemistry and laboratory medicine</jtitle><addtitle>Clin Chem Lab Med</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>49</volume><issue>8</issue><spage>1333</spage><epage>1339</epage><pages>1333-1339</pages><issn>1434-6621</issn><eissn>1437-4331</eissn><abstract><![CDATA[Background: Acute appendicitis (AA) is usually associated with a systemic inflammatory response that often leads to activation of coagulation. However, limited data about coagulation changes in AA are available. Methods: Results of preoperative coagulation testing in 702 patients with confirmed AA and 697 patients undergoing minor elective surgery (control) during the same period were analyzed retrospectively. Coagulation activity of factors VII, IX (FVII:C, FIX:C) and the concentration of plasma endotoxin from 40 patients with AA and 15 control subjects were measured. Results: Compared with control subjects, prothrombin time (PT), fibrinogen (Fib) and endotoxin increased (all p<0.01), FVII:C decreased (p<0.05), and thrombin time shortened (p<0.01) significantly in patients with AA, which showed trends with increasing severity of disease. Areas under the receiver operating characteristic curve of Fib for discriminating complicated appendicitis or acute perforated appendicitis from enrolled patients were larger than those for leukocyte parameters. The concentration of endotoxin correlated negatively with FVII:C (r=−0.860, p<0.001), positively with PT (0.713, <0.001), and FVII:C negatively with PT (−0.729, <0.001) in individuals that were evaluated. The change in activated partial thromboplastin time and difference in FIX:C among patients with various pathological types of appendicitis were not significant. Conclusions: Endotoxin-induced activation of the extrinsic coagulation pathway was present in patients with AA. Fib may be useful as a potential indicator for excluding complicated appendicitis.]]></abstract><cop>Berlin</cop><pub>Walter de Gruyter</pub><pmid>21663567</pmid><doi>10.1515/CCLM.2011.214</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; De Gruyter journals |
| subjects | acute appendicitis Acute Disease Adult Appendicitis - blood Appendicitis - complications Area Under Curve Bacteremia - complications Biological and medical sciences Blood Coagulation Tests coagulation factor coagulation screening tests endotoxin Endotoxins - blood Factor VII - metabolism Factor X - metabolism Female Fibrinogen - analysis Gastroenterology. Liver. Pancreas. Abdomen General aspects Humans Investigative techniques, diagnostic techniques (general aspects) leukocyte parameters Male Medical sciences Middle Aged Other diseases. Semiology Preoperative Period Prothrombin Time Retrospective Studies Stomach. Duodenum. Small intestine. Colon. Rectum. Anus |
| title | Alterations of the preoperative coagulation profile in patients with acute appendicitis |
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