Evaluation of the DCA Vantage analyzer for HbA1c assay
Background: Measurement of HbA1c is key in monitoring diabetic patients in both laboratories and clinical units, where HbA1c results are used as part of patient education. Methods: We have evaluated the DCA Vantage®, a new device for immunological assay of HbA1c. HbA1c results obtained were evaluate...
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| Veröffentlicht in: | Clinical chemistry and laboratory medicine 2008-08, Vol.46 (8), p.1195-1198 |
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| container_title | Clinical chemistry and laboratory medicine |
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| creator | Szymezak, Jean Leroy, Nathalie Lavalard, Emmanuelle Gillery, Philippe |
| description | Background: Measurement of HbA1c is key in monitoring diabetic patients in both laboratories and clinical units, where HbA1c results are used as part of patient education. Methods: We have evaluated the DCA Vantage®, a new device for immunological assay of HbA1c. HbA1c results obtained were evaluated in terms of precision, linearity, specificity and practicability, and were compared with results obtained by a Variant II® HPLC method. Results: The method exhibited intra- and inter-assay coefficients of variation lower than 2.6% and 4.0%, respectively, and good correlation with the comparison HPLC method (r2=0.9776). No interference was noted in the presence of labile HbA1c or carbamylated hemoglobin. The new device exhibited improved practicability characteristics and allowed better sample identification, better management of quality control routines and greater connectivity possibilities compared to the previous DCA 2000® analyzer. Conclusions: This new analyzer exhibited analytical and practical characteristics very suitable for HbA1c assay for laboratory or point-of-care use according to good laboratory practice. Clin Chem Lab Med 2008;46:1195–8. |
| doi_str_mv | 10.1515/CCLM.2008.228 |
| format | Article |
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Methods: We have evaluated the DCA Vantage®, a new device for immunological assay of HbA1c. HbA1c results obtained were evaluated in terms of precision, linearity, specificity and practicability, and were compared with results obtained by a Variant II® HPLC method. Results: The method exhibited intra- and inter-assay coefficients of variation lower than 2.6% and 4.0%, respectively, and good correlation with the comparison HPLC method (r2=0.9776). No interference was noted in the presence of labile HbA1c or carbamylated hemoglobin. The new device exhibited improved practicability characteristics and allowed better sample identification, better management of quality control routines and greater connectivity possibilities compared to the previous DCA 2000® analyzer. Conclusions: This new analyzer exhibited analytical and practical characteristics very suitable for HbA1c assay for laboratory or point-of-care use according to good laboratory practice. Clin Chem Lab Med 2008;46:1195–8.</description><identifier>ISSN: 1434-6621</identifier><identifier>EISSN: 1437-4331</identifier><identifier>DOI: 10.1515/CCLM.2008.228</identifier><language>eng</language><publisher>Berlin: Walter de Gruyter</publisher><subject>Biological and medical sciences ; diabetes mellitus ; evaluation ; General aspects ; HbA1c ; immunoassay ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; patient outcome ; point-of-care testing</subject><ispartof>Clinical chemistry and laboratory medicine, 2008-08, Vol.46 (8), p.1195-1198</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c220t-538e9895fee7814fbdcddf1c04668c2799f180ccb5373d06dc4950b29c561d803</citedby><cites>FETCH-LOGICAL-c220t-538e9895fee7814fbdcddf1c04668c2799f180ccb5373d06dc4950b29c561d803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20603200$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Szymezak, Jean</creatorcontrib><creatorcontrib>Leroy, Nathalie</creatorcontrib><creatorcontrib>Lavalard, Emmanuelle</creatorcontrib><creatorcontrib>Gillery, Philippe</creatorcontrib><title>Evaluation of the DCA Vantage analyzer for HbA1c assay</title><title>Clinical chemistry and laboratory medicine</title><description>Background: Measurement of HbA1c is key in monitoring diabetic patients in both laboratories and clinical units, where HbA1c results are used as part of patient education. Methods: We have evaluated the DCA Vantage®, a new device for immunological assay of HbA1c. HbA1c results obtained were evaluated in terms of precision, linearity, specificity and practicability, and were compared with results obtained by a Variant II® HPLC method. Results: The method exhibited intra- and inter-assay coefficients of variation lower than 2.6% and 4.0%, respectively, and good correlation with the comparison HPLC method (r2=0.9776). No interference was noted in the presence of labile HbA1c or carbamylated hemoglobin. The new device exhibited improved practicability characteristics and allowed better sample identification, better management of quality control routines and greater connectivity possibilities compared to the previous DCA 2000® analyzer. Conclusions: This new analyzer exhibited analytical and practical characteristics very suitable for HbA1c assay for laboratory or point-of-care use according to good laboratory practice. 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Methods: We have evaluated the DCA Vantage®, a new device for immunological assay of HbA1c. HbA1c results obtained were evaluated in terms of precision, linearity, specificity and practicability, and were compared with results obtained by a Variant II® HPLC method. Results: The method exhibited intra- and inter-assay coefficients of variation lower than 2.6% and 4.0%, respectively, and good correlation with the comparison HPLC method (r2=0.9776). No interference was noted in the presence of labile HbA1c or carbamylated hemoglobin. The new device exhibited improved practicability characteristics and allowed better sample identification, better management of quality control routines and greater connectivity possibilities compared to the previous DCA 2000® analyzer. Conclusions: This new analyzer exhibited analytical and practical characteristics very suitable for HbA1c assay for laboratory or point-of-care use according to good laboratory practice. 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| ispartof | Clinical chemistry and laboratory medicine, 2008-08, Vol.46 (8), p.1195-1198 |
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| source | De Gruyter journals |
| subjects | Biological and medical sciences diabetes mellitus evaluation General aspects HbA1c immunoassay Investigative techniques, diagnostic techniques (general aspects) Medical sciences patient outcome point-of-care testing |
| title | Evaluation of the DCA Vantage analyzer for HbA1c assay |
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