Metzincin's canonical methionine is responsible for the structural integrity of the zinc-binding site

The metzincins constitute a subclan of metalloproteases possessing a HEXXHXXGXXH/D zinc-binding consensus sequence where the three histidines are zinc ligands and the glutamic acid is the catalytic base. A completely conserved methionine is located downstream of this motif. Families of the metzincin...

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Veröffentlicht in:	Biological chemistry 2009-09, Vol.390 (9), p.875-881
Hauptverfasser:	Oberholzer, Anselm E., Bumann, Mario, Hege, Thomas, Russo, Santina, Baumann, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites - genetics Binding Sites - physiology crystal structure directed mutagenesis Metalloendopeptidases - chemistry Metalloendopeptidases - metabolism metalloprotease Methionine - chemistry Methionine - genetics Methionine - physiology metzincin Mutagenesis, Site-Directed Protein Binding - genetics Protein Binding - physiology Protein Structure, Secondary serralysin Zinc - metabolism
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