5-Hydroxyeicosatetraenoic Acid and Phorbol Ester Stimulate Prolactin Release from Rat Anterior Pituitary Cells by Different Mechanisms
The relationship between 5-hydroxyeicosatetraenoic acid (5-HETE) and calcium-activated, phospholipid-dependent protein kinase (protein kinase C) in prolactin (PRL) release was investigated in rat anterior pituitary cells. Arachidonic acid or 5-HETE, a 5-lipoxygenase metabolite of arachidonic acid, i...
Gespeichert in:
| Veröffentlicht in: | Endocrinologia Japonica 1990, Vol.37(6), pp.809-817 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 817 |
|---|---|
| container_issue | 6 |
| container_start_page | 809 |
| container_title | Endocrinologia Japonica |
| container_volume | 37 |
| creator | IKEGAMI, HIROMASA HIROTA, KENJI KOIKE, KOJI JIKIHARA, HIROAKI MIYAKE, AKIRA AONO, TOSHIHIRO TANIZAWA, OSAMU |
| description | The relationship between 5-hydroxyeicosatetraenoic acid (5-HETE) and calcium-activated, phospholipid-dependent protein kinase (protein kinase C) in prolactin (PRL) release was investigated in rat anterior pituitary cells. Arachidonic acid or 5-HETE, a 5-lipoxygenase metabolite of arachidonic acid, is known to cause a significant concentration-dependent increase in PRL release. Phorbol 12-myristate 13-acetate (PMA) and dioctanoyglycerol (diC8) have also been known to stimulate PRL release from pituitary cells, so we showed that these PRL releases were correlated with the activation of protein kinase C, that is, they induced dose-dependent translocation of protein kinase C from the cytosol to the membrane. Arachidonic acid, however, did not cause a significant change in the distribution of protein kinase C. We also showed that the PRL release induced by arachidonic acid and that induced by 5-HETE were additional to that by 100nM PMA. Thus we suggested that the signals for the stimulation of PRL release sent by arachidonic acid and 5-HETE would be different from the signal sent through protein kinase C by PMA. |
| doi_str_mv | 10.1507/endocrj1954.37.809 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1507_endocrj1954_37_809</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2129302</sourcerecordid><originalsourceid>FETCH-LOGICAL-c491t-2028f23fe43e0d83ef337e1178d4cf54e624e0473f94cec8b95fae3b53a1f54c3</originalsourceid><addsrcrecordid>eNpdkM1qGzEURkVocYzrFygEtOlyHP3NaGZp3NQOpNQ46XrQaK5iGc0oSDLEL9DnroqNW6qFtPjOd3U5CH2mZEFLIu9h7L0OB9qUYsHloibNDZoyWpdFxSX5gKaEUF5IRptbNI_xQPKpWCUFmaAJo6zhhE3Rr7LYnPrg309gtY8qQQoKRm81XmrbYzX2eLv3ofMOP8QEAT8nOxxdBvE2eKd0siPegQMVAZvgB7xTCS_HjFof8Namo00qnPAKnIu4O-Gv1hgIMCb8HfRejTYO8RP6aJSLML-8M_Tz28PLalM8_Vg_rpZPhRYNTQUjrDaMGxAcSF9zMJxLoFTWvdCmFFAxAURIbhqhQdddUxoFvCu5ojnWfIbYea4OPsYApn0LdsjrtZS0f7S2_2htuWyz1ly6O5fejt0A_bVykZjzL5dcRa2cCWrUNv6d3NSCCkEytz5zh5jUK1wBFZLVDv7_ujpfeYMrkXWFjPHfgYid9A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>5-Hydroxyeicosatetraenoic Acid and Phorbol Ester Stimulate Prolactin Release from Rat Anterior Pituitary Cells by Different Mechanisms</title><source>MEDLINE</source><source>EZB Electronic Journals Library</source><source>J-STAGE</source><creator>IKEGAMI, HIROMASA ; HIROTA, KENJI ; KOIKE, KOJI ; JIKIHARA, HIROAKI ; MIYAKE, AKIRA ; AONO, TOSHIHIRO ; TANIZAWA, OSAMU</creator><creatorcontrib>IKEGAMI, HIROMASA ; HIROTA, KENJI ; KOIKE, KOJI ; JIKIHARA, HIROAKI ; MIYAKE, AKIRA ; AONO, TOSHIHIRO ; TANIZAWA, OSAMU</creatorcontrib><description>The relationship between 5-hydroxyeicosatetraenoic acid (5-HETE) and calcium-activated, phospholipid-dependent protein kinase (protein kinase C) in prolactin (PRL) release was investigated in rat anterior pituitary cells. Arachidonic acid or 5-HETE, a 5-lipoxygenase metabolite of arachidonic acid, is known to cause a significant concentration-dependent increase in PRL release. Phorbol 12-myristate 13-acetate (PMA) and dioctanoyglycerol (diC8) have also been known to stimulate PRL release from pituitary cells, so we showed that these PRL releases were correlated with the activation of protein kinase C, that is, they induced dose-dependent translocation of protein kinase C from the cytosol to the membrane. Arachidonic acid, however, did not cause a significant change in the distribution of protein kinase C. We also showed that the PRL release induced by arachidonic acid and that induced by 5-HETE were additional to that by 100nM PMA. Thus we suggested that the signals for the stimulation of PRL release sent by arachidonic acid and 5-HETE would be different from the signal sent through protein kinase C by PMA.</description><identifier>ISSN: 0013-7219</identifier><identifier>EISSN: 2185-6370</identifier><identifier>DOI: 10.1507/endocrj1954.37.809</identifier><identifier>PMID: 2129302</identifier><identifier>CODEN: ECJPAE</identifier><language>eng</language><publisher>Tokyo: The Japan Endocrine Society</publisher><subject>Animals ; Arachidonic Acid ; Arachidonic Acids - pharmacology ; Biological and medical sciences ; Cells, Cultured ; Drug Interactions ; Female ; Fundamental and applied biological sciences. Psychology ; Hormones and neuropeptides. Regulation ; Hydroxyeicosatetraenoic Acids - pharmacology ; Hypothalamus. Hypophysis. Epiphysis. Urophysis ; Pituitary Gland, Anterior - cytology ; Pituitary Gland, Anterior - drug effects ; Pituitary Gland, Anterior - metabolism ; Prolactin - metabolism ; Protein Kinase C - blood ; Radioimmunoassay ; Rats ; Rats, Inbred Strains ; Tetradecanoylphorbol Acetate - pharmacology ; Vertebrates: endocrinology</subject><ispartof>Endocrinologia Japonica, 1990, Vol.37(6), pp.809-817</ispartof><rights>The Japan Endocrine Society</rights><rights>1991 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-2028f23fe43e0d83ef337e1178d4cf54e624e0473f94cec8b95fae3b53a1f54c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19841440$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2129302$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>IKEGAMI, HIROMASA</creatorcontrib><creatorcontrib>HIROTA, KENJI</creatorcontrib><creatorcontrib>KOIKE, KOJI</creatorcontrib><creatorcontrib>JIKIHARA, HIROAKI</creatorcontrib><creatorcontrib>MIYAKE, AKIRA</creatorcontrib><creatorcontrib>AONO, TOSHIHIRO</creatorcontrib><creatorcontrib>TANIZAWA, OSAMU</creatorcontrib><title>5-Hydroxyeicosatetraenoic Acid and Phorbol Ester Stimulate Prolactin Release from Rat Anterior Pituitary Cells by Different Mechanisms</title><title>Endocrinologia Japonica</title><addtitle>Endocrinol Japon</addtitle><description>The relationship between 5-hydroxyeicosatetraenoic acid (5-HETE) and calcium-activated, phospholipid-dependent protein kinase (protein kinase C) in prolactin (PRL) release was investigated in rat anterior pituitary cells. Arachidonic acid or 5-HETE, a 5-lipoxygenase metabolite of arachidonic acid, is known to cause a significant concentration-dependent increase in PRL release. Phorbol 12-myristate 13-acetate (PMA) and dioctanoyglycerol (diC8) have also been known to stimulate PRL release from pituitary cells, so we showed that these PRL releases were correlated with the activation of protein kinase C, that is, they induced dose-dependent translocation of protein kinase C from the cytosol to the membrane. Arachidonic acid, however, did not cause a significant change in the distribution of protein kinase C. We also showed that the PRL release induced by arachidonic acid and that induced by 5-HETE were additional to that by 100nM PMA. Thus we suggested that the signals for the stimulation of PRL release sent by arachidonic acid and 5-HETE would be different from the signal sent through protein kinase C by PMA.</description><subject>Animals</subject><subject>Arachidonic Acid</subject><subject>Arachidonic Acids - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Drug Interactions</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Hydroxyeicosatetraenoic Acids - pharmacology</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Pituitary Gland, Anterior - cytology</subject><subject>Pituitary Gland, Anterior - drug effects</subject><subject>Pituitary Gland, Anterior - metabolism</subject><subject>Prolactin - metabolism</subject><subject>Protein Kinase C - blood</subject><subject>Radioimmunoassay</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Tetradecanoylphorbol Acetate - pharmacology</subject><subject>Vertebrates: endocrinology</subject><issn>0013-7219</issn><issn>2185-6370</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkM1qGzEURkVocYzrFygEtOlyHP3NaGZp3NQOpNQ46XrQaK5iGc0oSDLEL9DnroqNW6qFtPjOd3U5CH2mZEFLIu9h7L0OB9qUYsHloibNDZoyWpdFxSX5gKaEUF5IRptbNI_xQPKpWCUFmaAJo6zhhE3Rr7LYnPrg309gtY8qQQoKRm81XmrbYzX2eLv3ofMOP8QEAT8nOxxdBvE2eKd0siPegQMVAZvgB7xTCS_HjFof8Namo00qnPAKnIu4O-Gv1hgIMCb8HfRejTYO8RP6aJSLML-8M_Tz28PLalM8_Vg_rpZPhRYNTQUjrDaMGxAcSF9zMJxLoFTWvdCmFFAxAURIbhqhQdddUxoFvCu5ojnWfIbYea4OPsYApn0LdsjrtZS0f7S2_2htuWyz1ly6O5fejt0A_bVykZjzL5dcRa2cCWrUNv6d3NSCCkEytz5zh5jUK1wBFZLVDv7_ujpfeYMrkXWFjPHfgYid9A</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>IKEGAMI, HIROMASA</creator><creator>HIROTA, KENJI</creator><creator>KOIKE, KOJI</creator><creator>JIKIHARA, HIROAKI</creator><creator>MIYAKE, AKIRA</creator><creator>AONO, TOSHIHIRO</creator><creator>TANIZAWA, OSAMU</creator><general>The Japan Endocrine Society</general><general>Japan Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1990</creationdate><title>5-Hydroxyeicosatetraenoic Acid and Phorbol Ester Stimulate Prolactin Release from Rat Anterior Pituitary Cells by Different Mechanisms</title><author>IKEGAMI, HIROMASA ; HIROTA, KENJI ; KOIKE, KOJI ; JIKIHARA, HIROAKI ; MIYAKE, AKIRA ; AONO, TOSHIHIRO ; TANIZAWA, OSAMU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-2028f23fe43e0d83ef337e1178d4cf54e624e0473f94cec8b95fae3b53a1f54c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Arachidonic Acid</topic><topic>Arachidonic Acids - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Drug Interactions</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Hydroxyeicosatetraenoic Acids - pharmacology</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Pituitary Gland, Anterior - cytology</topic><topic>Pituitary Gland, Anterior - drug effects</topic><topic>Pituitary Gland, Anterior - metabolism</topic><topic>Prolactin - metabolism</topic><topic>Protein Kinase C - blood</topic><topic>Radioimmunoassay</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Tetradecanoylphorbol Acetate - pharmacology</topic><topic>Vertebrates: endocrinology</topic><toplevel>online_resources</toplevel><creatorcontrib>IKEGAMI, HIROMASA</creatorcontrib><creatorcontrib>HIROTA, KENJI</creatorcontrib><creatorcontrib>KOIKE, KOJI</creatorcontrib><creatorcontrib>JIKIHARA, HIROAKI</creatorcontrib><creatorcontrib>MIYAKE, AKIRA</creatorcontrib><creatorcontrib>AONO, TOSHIHIRO</creatorcontrib><creatorcontrib>TANIZAWA, OSAMU</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Endocrinologia Japonica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>IKEGAMI, HIROMASA</au><au>HIROTA, KENJI</au><au>KOIKE, KOJI</au><au>JIKIHARA, HIROAKI</au><au>MIYAKE, AKIRA</au><au>AONO, TOSHIHIRO</au><au>TANIZAWA, OSAMU</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>5-Hydroxyeicosatetraenoic Acid and Phorbol Ester Stimulate Prolactin Release from Rat Anterior Pituitary Cells by Different Mechanisms</atitle><jtitle>Endocrinologia Japonica</jtitle><addtitle>Endocrinol Japon</addtitle><date>1990</date><risdate>1990</risdate><volume>37</volume><issue>6</issue><spage>809</spage><epage>817</epage><pages>809-817</pages><issn>0013-7219</issn><eissn>2185-6370</eissn><coden>ECJPAE</coden><abstract>The relationship between 5-hydroxyeicosatetraenoic acid (5-HETE) and calcium-activated, phospholipid-dependent protein kinase (protein kinase C) in prolactin (PRL) release was investigated in rat anterior pituitary cells. Arachidonic acid or 5-HETE, a 5-lipoxygenase metabolite of arachidonic acid, is known to cause a significant concentration-dependent increase in PRL release. Phorbol 12-myristate 13-acetate (PMA) and dioctanoyglycerol (diC8) have also been known to stimulate PRL release from pituitary cells, so we showed that these PRL releases were correlated with the activation of protein kinase C, that is, they induced dose-dependent translocation of protein kinase C from the cytosol to the membrane. Arachidonic acid, however, did not cause a significant change in the distribution of protein kinase C. We also showed that the PRL release induced by arachidonic acid and that induced by 5-HETE were additional to that by 100nM PMA. Thus we suggested that the signals for the stimulation of PRL release sent by arachidonic acid and 5-HETE would be different from the signal sent through protein kinase C by PMA.</abstract><cop>Tokyo</cop><pub>The Japan Endocrine Society</pub><pmid>2129302</pmid><doi>10.1507/endocrj1954.37.809</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0013-7219 |
| ispartof | Endocrinologia Japonica, 1990, Vol.37(6), pp.809-817 |
| issn | 0013-7219 2185-6370 |
| language | eng |
| recordid | cdi_crossref_primary_10_1507_endocrj1954_37_809 |
| source | MEDLINE; EZB Electronic Journals Library; J-STAGE |
| subjects | Animals Arachidonic Acid Arachidonic Acids - pharmacology Biological and medical sciences Cells, Cultured Drug Interactions Female Fundamental and applied biological sciences. Psychology Hormones and neuropeptides. Regulation Hydroxyeicosatetraenoic Acids - pharmacology Hypothalamus. Hypophysis. Epiphysis. Urophysis Pituitary Gland, Anterior - cytology Pituitary Gland, Anterior - drug effects Pituitary Gland, Anterior - metabolism Prolactin - metabolism Protein Kinase C - blood Radioimmunoassay Rats Rats, Inbred Strains Tetradecanoylphorbol Acetate - pharmacology Vertebrates: endocrinology |
| title | 5-Hydroxyeicosatetraenoic Acid and Phorbol Ester Stimulate Prolactin Release from Rat Anterior Pituitary Cells by Different Mechanisms |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T17%3A44%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=5-Hydroxyeicosatetraenoic%20Acid%20and%20Phorbol%20Ester%20Stimulate%20Prolactin%20Release%20from%20Rat%20Anterior%20Pituitary%20Cells%20by%20Different%20Mechanisms&rft.jtitle=Endocrinologia%20Japonica&rft.au=IKEGAMI,%20HIROMASA&rft.date=1990&rft.volume=37&rft.issue=6&rft.spage=809&rft.epage=817&rft.pages=809-817&rft.issn=0013-7219&rft.eissn=2185-6370&rft.coden=ECJPAE&rft_id=info:doi/10.1507/endocrj1954.37.809&rft_dat=%3Cpubmed_cross%3E2129302%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/2129302&rfr_iscdi=true |