Drastic changes in the substrate specificity of geranylgeranyl diphosphate synthase from Sulfolobus acidocaldarius by a single amino acid substitution

Geranylgeranyl diphosphate (GGPP) synthase catalyzes the condensation of isopentenyl diphosphate with dimethylallyl diphosphate, geranyl diphosphate or farnesyl diphosphate to produce GGPP as the final product. GGPP synthase in the thermophilic bacterium Sulfolobus acidocaldarius can hardly accept s...

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Veröffentlicht in:	Transactions of the Materials Research Society of Japan 2012/06/01, Vol.37(2), pp.325-328
Hauptverfasser:	Nakamura, Takeshi, Nagaki, Masahiko, Ohya, Norimasa
Format:	Artikel
Sprache:	eng
Schlagworte:	geranylgeranyl diphosphate prenyltransferase substrate analog substrate specificity
Online-Zugang:	Volltext
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