Evaluation of α-Amylase Inhibitory Activity, Molecular Modeling, Total Antioxidant and Theoretical Studies of Novel Schiff Base Transition Metal Complexes
By condensing pyrene-1-carbaldehyde and 4-aminoantipyrine, a Schiff base ligand, (Z)-1,5-dimethyl-2-phenyl-4-((pyren-1-ylmethylene)- amino)-1H-pyrazol-3(2H)-one and its Cu(II), Ni(II), Co(II) and Zn(II) complexes have been synthesized. The ligand and its metal complexes were characterized by FT-IR,...
Gespeichert in:
| Veröffentlicht in: | Asian journal of chemistry 2020-09, Vol.32 (9), p.2187-2194 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2194 |
|---|---|
| container_issue | 9 |
| container_start_page | 2187 |
| container_title | Asian journal of chemistry |
| container_volume | 32 |
| creator | SUDHA, A. ARULMOZHI, S. ASKAR ALI, S.J. |
| description | By condensing pyrene-1-carbaldehyde and 4-aminoantipyrine, a Schiff base ligand, (Z)-1,5-dimethyl-2-phenyl-4-((pyren-1-ylmethylene)-
amino)-1H-pyrazol-3(2H)-one and its Cu(II), Ni(II), Co(II) and Zn(II) complexes have been synthesized. The ligand and its metal complexes
were characterized by FT-IR, UV-visible, 1H & 13C NMR, ESI-mass spectra and elemental analysis. The antidiabetic and antioxidant
activities of the synthesized Schiff base ligand and its metal complexes were studied. The molecular docking study of human pancreatic
α-amylase (PDB: 1HNY). Furthermore, Theoretical analysis of geometry optimization and frontier molecular orbital analysis (HOMOLUMO)
was accomplished by density functional theory using B3LYP/3-21G*++ basis sets to understand the chemical stability of the
synthesized ligand and their metal(II) complexes. |
| doi_str_mv | 10.14233/ajchem.2020.22783 |
| format | Article |
| fullrecord | <record><control><sourceid>crossref</sourceid><recordid>TN_cdi_crossref_primary_10_14233_ajchem_2020_22783</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_14233_ajchem_2020_22783</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1573-8bd96a3279c2fddcb2f8838310a09be2c75e4ff7d02eb955039c99d9e4149fd83</originalsourceid><addsrcrecordid>eNotkEFOwzAQRSMEElXpBVj5AE1x7KSOl6EqUKmFBUFiFzn2mLhK4ipOq-YsnIKLcCaSlNnM14z0_9fzvPsAL4KQUPog9rKAakEwwQtCWEyvvAnmLPJDwj6vR419hhm79WbO7XE_yyAijEy87_VJlEfRGlsjq9Hvj59UXSkcoE1dmNy0tulQIltzMm03RztbgjyWoumVgtLUX3OU2laUKKl7j7NRom6RqBVKC7ANtEb2v_f2qAy4IeDVnqA_yMJojR6HnLQRtTNjgR0MTitbHUo4g7vzbrQoHcz-99T7eFqnqxd_-_a8WSVbXwYRo36cK74UlDAuiVZK5kTHMY1pgAXmORDJIgi1ZgoTyHkUYcol54pDGIRcq5hOPXLxlY11rgGdHRpTiabLApyNhLML4WwgnI2E6R-0RXQF</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Evaluation of α-Amylase Inhibitory Activity, Molecular Modeling, Total Antioxidant and Theoretical Studies of Novel Schiff Base Transition Metal Complexes</title><source>Alma/SFX Local Collection</source><creator>SUDHA, A. ; ARULMOZHI, S. ; ASKAR ALI, S.J.</creator><creatorcontrib>SUDHA, A. ; ARULMOZHI, S. ; ASKAR ALI, S.J.</creatorcontrib><description>By condensing pyrene-1-carbaldehyde and 4-aminoantipyrine, a Schiff base ligand, (Z)-1,5-dimethyl-2-phenyl-4-((pyren-1-ylmethylene)-
amino)-1H-pyrazol-3(2H)-one and its Cu(II), Ni(II), Co(II) and Zn(II) complexes have been synthesized. The ligand and its metal complexes
were characterized by FT-IR, UV-visible, 1H & 13C NMR, ESI-mass spectra and elemental analysis. The antidiabetic and antioxidant
activities of the synthesized Schiff base ligand and its metal complexes were studied. The molecular docking study of human pancreatic
α-amylase (PDB: 1HNY). Furthermore, Theoretical analysis of geometry optimization and frontier molecular orbital analysis (HOMOLUMO)
was accomplished by density functional theory using B3LYP/3-21G*++ basis sets to understand the chemical stability of the
synthesized ligand and their metal(II) complexes.</description><identifier>ISSN: 0970-7077</identifier><identifier>EISSN: 0975-427X</identifier><identifier>DOI: 10.14233/ajchem.2020.22783</identifier><language>eng</language><ispartof>Asian journal of chemistry, 2020-09, Vol.32 (9), p.2187-2194</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1573-8bd96a3279c2fddcb2f8838310a09be2c75e4ff7d02eb955039c99d9e4149fd83</cites><orcidid>0000-0001-8231-4203</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>SUDHA, A.</creatorcontrib><creatorcontrib>ARULMOZHI, S.</creatorcontrib><creatorcontrib>ASKAR ALI, S.J.</creatorcontrib><title>Evaluation of α-Amylase Inhibitory Activity, Molecular Modeling, Total Antioxidant and Theoretical Studies of Novel Schiff Base Transition Metal Complexes</title><title>Asian journal of chemistry</title><description>By condensing pyrene-1-carbaldehyde and 4-aminoantipyrine, a Schiff base ligand, (Z)-1,5-dimethyl-2-phenyl-4-((pyren-1-ylmethylene)-
amino)-1H-pyrazol-3(2H)-one and its Cu(II), Ni(II), Co(II) and Zn(II) complexes have been synthesized. The ligand and its metal complexes
were characterized by FT-IR, UV-visible, 1H & 13C NMR, ESI-mass spectra and elemental analysis. The antidiabetic and antioxidant
activities of the synthesized Schiff base ligand and its metal complexes were studied. The molecular docking study of human pancreatic
α-amylase (PDB: 1HNY). Furthermore, Theoretical analysis of geometry optimization and frontier molecular orbital analysis (HOMOLUMO)
was accomplished by density functional theory using B3LYP/3-21G*++ basis sets to understand the chemical stability of the
synthesized ligand and their metal(II) complexes.</description><issn>0970-7077</issn><issn>0975-427X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNotkEFOwzAQRSMEElXpBVj5AE1x7KSOl6EqUKmFBUFiFzn2mLhK4ipOq-YsnIKLcCaSlNnM14z0_9fzvPsAL4KQUPog9rKAakEwwQtCWEyvvAnmLPJDwj6vR419hhm79WbO7XE_yyAijEy87_VJlEfRGlsjq9Hvj59UXSkcoE1dmNy0tulQIltzMm03RztbgjyWoumVgtLUX3OU2laUKKl7j7NRom6RqBVKC7ANtEb2v_f2qAy4IeDVnqA_yMJojR6HnLQRtTNjgR0MTitbHUo4g7vzbrQoHcz-99T7eFqnqxd_-_a8WSVbXwYRo36cK74UlDAuiVZK5kTHMY1pgAXmORDJIgi1ZgoTyHkUYcol54pDGIRcq5hOPXLxlY11rgGdHRpTiabLApyNhLML4WwgnI2E6R-0RXQF</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>SUDHA, A.</creator><creator>ARULMOZHI, S.</creator><creator>ASKAR ALI, S.J.</creator><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0001-8231-4203</orcidid></search><sort><creationdate>20200901</creationdate><title>Evaluation of α-Amylase Inhibitory Activity, Molecular Modeling, Total Antioxidant and Theoretical Studies of Novel Schiff Base Transition Metal Complexes</title><author>SUDHA, A. ; ARULMOZHI, S. ; ASKAR ALI, S.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1573-8bd96a3279c2fddcb2f8838310a09be2c75e4ff7d02eb955039c99d9e4149fd83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>online_resources</toplevel><creatorcontrib>SUDHA, A.</creatorcontrib><creatorcontrib>ARULMOZHI, S.</creatorcontrib><creatorcontrib>ASKAR ALI, S.J.</creatorcontrib><collection>CrossRef</collection><jtitle>Asian journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SUDHA, A.</au><au>ARULMOZHI, S.</au><au>ASKAR ALI, S.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of α-Amylase Inhibitory Activity, Molecular Modeling, Total Antioxidant and Theoretical Studies of Novel Schiff Base Transition Metal Complexes</atitle><jtitle>Asian journal of chemistry</jtitle><date>2020-09-01</date><risdate>2020</risdate><volume>32</volume><issue>9</issue><spage>2187</spage><epage>2194</epage><pages>2187-2194</pages><issn>0970-7077</issn><eissn>0975-427X</eissn><abstract>By condensing pyrene-1-carbaldehyde and 4-aminoantipyrine, a Schiff base ligand, (Z)-1,5-dimethyl-2-phenyl-4-((pyren-1-ylmethylene)-
amino)-1H-pyrazol-3(2H)-one and its Cu(II), Ni(II), Co(II) and Zn(II) complexes have been synthesized. The ligand and its metal complexes
were characterized by FT-IR, UV-visible, 1H & 13C NMR, ESI-mass spectra and elemental analysis. The antidiabetic and antioxidant
activities of the synthesized Schiff base ligand and its metal complexes were studied. The molecular docking study of human pancreatic
α-amylase (PDB: 1HNY). Furthermore, Theoretical analysis of geometry optimization and frontier molecular orbital analysis (HOMOLUMO)
was accomplished by density functional theory using B3LYP/3-21G*++ basis sets to understand the chemical stability of the
synthesized ligand and their metal(II) complexes.</abstract><doi>10.14233/ajchem.2020.22783</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-8231-4203</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0970-7077 |
| ispartof | Asian journal of chemistry, 2020-09, Vol.32 (9), p.2187-2194 |
| issn | 0970-7077 0975-427X |
| language | eng |
| recordid | cdi_crossref_primary_10_14233_ajchem_2020_22783 |
| source | Alma/SFX Local Collection |
| title | Evaluation of α-Amylase Inhibitory Activity, Molecular Modeling, Total Antioxidant and Theoretical Studies of Novel Schiff Base Transition Metal Complexes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T18%3A14%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-crossref&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20%CE%B1-Amylase%20Inhibitory%20Activity,%20Molecular%20Modeling,%20Total%20Antioxidant%20and%20Theoretical%20Studies%20of%20Novel%20Schiff%20Base%20Transition%20Metal%20Complexes&rft.jtitle=Asian%20journal%20of%20chemistry&rft.au=SUDHA,%20A.&rft.date=2020-09-01&rft.volume=32&rft.issue=9&rft.spage=2187&rft.epage=2194&rft.pages=2187-2194&rft.issn=0970-7077&rft.eissn=0975-427X&rft_id=info:doi/10.14233/ajchem.2020.22783&rft_dat=%3Ccrossref%3E10_14233_ajchem_2020_22783%3C/crossref%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |