Treatment Effects of Low-Dose Theophylline Combined With an Inhaled Corticosteroid in COPD

Inhaled corticosteroids (ICS) have proved disappointing at reducing airway inflammation in COPD. However, previous studies indicate that low doses of theophylline enhance the activity of a key corticosteroid-associated corepressor protein, histone deacetylase (HDAC)2, which is reduced in COPD. This...

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Veröffentlicht in:Chest 2010-06, Vol.137 (6), p.1338-1344
Hauptverfasser: Ford, Paul A., Durham, Andrew L., Russell, Richard E.K., Gordon, Fabiana, Adcock, Ian M., Barnes, Peter J.
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Sprache:eng
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