Assessing the Relationship Between Lung Cancer Risk and Emphysema Detected on Low-Dose CT of the Chest
Rationale: Identification of risk factors for lung cancer can help in selecting patients who may benefit the most from smoking cessation interventions, early detection, or chemoprevention. To evaluate whether the presence of emphysema on low-radiation-dose CT (LDCT) of the chest is an independent ri...
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| Veröffentlicht in: | Chest 2007-12, Vol.132 (6), p.1932-1938 |
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| creator | de Torres, Juan P. Bastarrika, Gorka Wisnivesky, Juan P. Alcaide, Ana B. Campo, Arantza Seijo, Luis M. Pueyo, Jesús C. Villanueva, Alberto Lozano, María D. Montes, Usua Montuenga, Luis Zulueta, Javier J. |
| description | Rationale: Identification of risk factors for lung cancer can help in selecting patients who may benefit the most from smoking cessation interventions, early detection, or chemoprevention.
To evaluate whether the presence of emphysema on low-radiation-dose CT (LDCT) of the chest is an independent risk factor for lung cancer.
The study used data from a prospective cohort of 1,166 former and current smokers participating in a lung cancer screening study. All individuals underwent a baseline LDCT and spirometry followed by yearly repeat LDCT studies. The incidence density of lung cancer among patients with and without emphysema on LDCT was estimated. Stratified and multiple regression analyses were used to assess whether emphysema is an independent risk factor for lung cancer after adjusting for age, gender, smoking history, and the presence of airway obstruction on spirometry.
On univariate analysis, the incidence density of lung cancer among individuals with and without emphysema on LDCT was 25.0 per 1,000 person-years and 7.5 per 1,000 person-years, respectively (risk ratio [RR], 3.33; 95% confidence interval [CI], 1.41 to 7.85). Emphysema was also associated with increased risk of lung cancer when the analysis was limited to individuals without airway obstruction on spirometry (RR, 4.33; 95% CI, 1.04 to 18.16). Multivariate analysis showed that the presence of emphysema (RR, 2.51; 95% CI, 1.01 to 6.23) on LDCT but not airway obstruction (RR, 2.10; 95% CI, 0.79 to 5.58) was associated with increased risk of lung cancer after adjusting for potential cofounders.
Results suggest that the presence of emphysema on LDCT is an independent risk factor for lung cancer. |
| doi_str_mv | 10.1378/chest.07-1490 |
| format | Article |
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To evaluate whether the presence of emphysema on low-radiation-dose CT (LDCT) of the chest is an independent risk factor for lung cancer.
The study used data from a prospective cohort of 1,166 former and current smokers participating in a lung cancer screening study. All individuals underwent a baseline LDCT and spirometry followed by yearly repeat LDCT studies. The incidence density of lung cancer among patients with and without emphysema on LDCT was estimated. Stratified and multiple regression analyses were used to assess whether emphysema is an independent risk factor for lung cancer after adjusting for age, gender, smoking history, and the presence of airway obstruction on spirometry.
On univariate analysis, the incidence density of lung cancer among individuals with and without emphysema on LDCT was 25.0 per 1,000 person-years and 7.5 per 1,000 person-years, respectively (risk ratio [RR], 3.33; 95% confidence interval [CI], 1.41 to 7.85). Emphysema was also associated with increased risk of lung cancer when the analysis was limited to individuals without airway obstruction on spirometry (RR, 4.33; 95% CI, 1.04 to 18.16). Multivariate analysis showed that the presence of emphysema (RR, 2.51; 95% CI, 1.01 to 6.23) on LDCT but not airway obstruction (RR, 2.10; 95% CI, 0.79 to 5.58) was associated with increased risk of lung cancer after adjusting for potential cofounders.
Results suggest that the presence of emphysema on LDCT is an independent risk factor for lung cancer.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.07-1490</identifier><identifier>PMID: 18079226</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>airway obstruction ; Algorithms ; Biological and medical sciences ; Cardiology. Vascular system ; Chronic obstructive pulmonary disease, asthma ; emphysema ; Female ; Humans ; Incidence ; lung cancer ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - epidemiology ; Lung Neoplasms - pathology ; Male ; Medical sciences ; Middle Aged ; Pneumology ; Poisson Distribution ; Prospective Studies ; Pulmonary Emphysema - diagnostic imaging ; Pulmonary Emphysema - epidemiology ; Pulmonary Emphysema - pathology ; Radiography, Thoracic ; Regression Analysis ; Risk Factors ; Smoking - epidemiology ; Spain - epidemiology ; Spirometry ; Surveys and Questionnaires ; Tomography, X-Ray Computed ; Tumors of the respiratory system and mediastinum</subject><ispartof>Chest, 2007-12, Vol.132 (6), p.1932-1938</ispartof><rights>2007 The American College of Chest Physicians</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-839ae3bd194388c74a45fe846ed3cf1040f34cdea7bd39fbe2e400bb5f1c6ae3</citedby><cites>FETCH-LOGICAL-c484t-839ae3bd194388c74a45fe846ed3cf1040f34cdea7bd39fbe2e400bb5f1c6ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19919130$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18079226$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Torres, Juan P.</creatorcontrib><creatorcontrib>Bastarrika, Gorka</creatorcontrib><creatorcontrib>Wisnivesky, Juan P.</creatorcontrib><creatorcontrib>Alcaide, Ana B.</creatorcontrib><creatorcontrib>Campo, Arantza</creatorcontrib><creatorcontrib>Seijo, Luis M.</creatorcontrib><creatorcontrib>Pueyo, Jesús C.</creatorcontrib><creatorcontrib>Villanueva, Alberto</creatorcontrib><creatorcontrib>Lozano, María D.</creatorcontrib><creatorcontrib>Montes, Usua</creatorcontrib><creatorcontrib>Montuenga, Luis</creatorcontrib><creatorcontrib>Zulueta, Javier J.</creatorcontrib><title>Assessing the Relationship Between Lung Cancer Risk and Emphysema Detected on Low-Dose CT of the Chest</title><title>Chest</title><addtitle>Chest</addtitle><description>Rationale: Identification of risk factors for lung cancer can help in selecting patients who may benefit the most from smoking cessation interventions, early detection, or chemoprevention.
To evaluate whether the presence of emphysema on low-radiation-dose CT (LDCT) of the chest is an independent risk factor for lung cancer.
The study used data from a prospective cohort of 1,166 former and current smokers participating in a lung cancer screening study. All individuals underwent a baseline LDCT and spirometry followed by yearly repeat LDCT studies. The incidence density of lung cancer among patients with and without emphysema on LDCT was estimated. Stratified and multiple regression analyses were used to assess whether emphysema is an independent risk factor for lung cancer after adjusting for age, gender, smoking history, and the presence of airway obstruction on spirometry.
On univariate analysis, the incidence density of lung cancer among individuals with and without emphysema on LDCT was 25.0 per 1,000 person-years and 7.5 per 1,000 person-years, respectively (risk ratio [RR], 3.33; 95% confidence interval [CI], 1.41 to 7.85). Emphysema was also associated with increased risk of lung cancer when the analysis was limited to individuals without airway obstruction on spirometry (RR, 4.33; 95% CI, 1.04 to 18.16). Multivariate analysis showed that the presence of emphysema (RR, 2.51; 95% CI, 1.01 to 6.23) on LDCT but not airway obstruction (RR, 2.10; 95% CI, 0.79 to 5.58) was associated with increased risk of lung cancer after adjusting for potential cofounders.
Results suggest that the presence of emphysema on LDCT is an independent risk factor for lung cancer.</description><subject>airway obstruction</subject><subject>Algorithms</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>emphysema</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>lung cancer</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pneumology</subject><subject>Poisson Distribution</subject><subject>Prospective Studies</subject><subject>Pulmonary Emphysema - diagnostic imaging</subject><subject>Pulmonary Emphysema - epidemiology</subject><subject>Pulmonary Emphysema - pathology</subject><subject>Radiography, Thoracic</subject><subject>Regression Analysis</subject><subject>Risk Factors</subject><subject>Smoking - epidemiology</subject><subject>Spain - epidemiology</subject><subject>Spirometry</subject><subject>Surveys and Questionnaires</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1P4zAQhi0EgvJx3OvKlz0G7NhN4iObsgtSJSTUu-XYY2I2H5Un3Yp_j0sqceJkjfy874weQn5wdstFWd3ZFnC6ZWXGpWInZMGV4JlYSnFKFozxPBOFyi_IJeIbSzNXxTm54BUrVZ4XC-LvEQExDK90aoG-QGemMA7Yhi39DdMeYKDrXfqtzWAh0peA_6gZHH3ot-07Qm_oCiawEzg6JnTcZ6sRgdYbOvrPyvpw4DU586ZDuDm-V2Tz52FTP2br579P9f06s7KSU1YJZUA0jispqsqW0silh0oW4IT1nEnmhbQOTNk4oXwDOUjGmmbpuS1S8opkc62NI2IEr7cx9Ca-a870QZf-1KVZqQ-6Ev9z5re7pgf3RR_9JODXETBoTedjshDwi1OKKy4ORWzm2vDa7kMEjb3pulQr5pVv4y4OpuMi10WKiTxFyjkCycf_AFGjDZAkuxS3k3Zj-ObqD3cNmJQ</recordid><startdate>20071201</startdate><enddate>20071201</enddate><creator>de Torres, Juan P.</creator><creator>Bastarrika, Gorka</creator><creator>Wisnivesky, Juan P.</creator><creator>Alcaide, Ana B.</creator><creator>Campo, Arantza</creator><creator>Seijo, Luis M.</creator><creator>Pueyo, Jesús C.</creator><creator>Villanueva, Alberto</creator><creator>Lozano, María D.</creator><creator>Montes, Usua</creator><creator>Montuenga, Luis</creator><creator>Zulueta, Javier J.</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20071201</creationdate><title>Assessing the Relationship Between Lung Cancer Risk and Emphysema Detected on Low-Dose CT of the Chest</title><author>de Torres, Juan P. ; Bastarrika, Gorka ; Wisnivesky, Juan P. ; Alcaide, Ana B. ; Campo, Arantza ; Seijo, Luis M. ; Pueyo, Jesús C. ; Villanueva, Alberto ; Lozano, María D. ; Montes, Usua ; Montuenga, Luis ; Zulueta, Javier J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-839ae3bd194388c74a45fe846ed3cf1040f34cdea7bd39fbe2e400bb5f1c6ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>airway obstruction</topic><topic>Algorithms</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>emphysema</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>lung cancer</topic><topic>Lung Neoplasms - diagnostic imaging</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pneumology</topic><topic>Poisson Distribution</topic><topic>Prospective Studies</topic><topic>Pulmonary Emphysema - diagnostic imaging</topic><topic>Pulmonary Emphysema - epidemiology</topic><topic>Pulmonary Emphysema - pathology</topic><topic>Radiography, Thoracic</topic><topic>Regression Analysis</topic><topic>Risk Factors</topic><topic>Smoking - epidemiology</topic><topic>Spain - epidemiology</topic><topic>Spirometry</topic><topic>Surveys and Questionnaires</topic><topic>Tomography, X-Ray Computed</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Torres, Juan P.</creatorcontrib><creatorcontrib>Bastarrika, Gorka</creatorcontrib><creatorcontrib>Wisnivesky, Juan P.</creatorcontrib><creatorcontrib>Alcaide, Ana B.</creatorcontrib><creatorcontrib>Campo, Arantza</creatorcontrib><creatorcontrib>Seijo, Luis M.</creatorcontrib><creatorcontrib>Pueyo, Jesús C.</creatorcontrib><creatorcontrib>Villanueva, Alberto</creatorcontrib><creatorcontrib>Lozano, María D.</creatorcontrib><creatorcontrib>Montes, Usua</creatorcontrib><creatorcontrib>Montuenga, Luis</creatorcontrib><creatorcontrib>Zulueta, Javier J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Torres, Juan P.</au><au>Bastarrika, Gorka</au><au>Wisnivesky, Juan P.</au><au>Alcaide, Ana B.</au><au>Campo, Arantza</au><au>Seijo, Luis M.</au><au>Pueyo, Jesús C.</au><au>Villanueva, Alberto</au><au>Lozano, María D.</au><au>Montes, Usua</au><au>Montuenga, Luis</au><au>Zulueta, Javier J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessing the Relationship Between Lung Cancer Risk and Emphysema Detected on Low-Dose CT of the Chest</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>132</volume><issue>6</issue><spage>1932</spage><epage>1938</epage><pages>1932-1938</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>Rationale: Identification of risk factors for lung cancer can help in selecting patients who may benefit the most from smoking cessation interventions, early detection, or chemoprevention.
To evaluate whether the presence of emphysema on low-radiation-dose CT (LDCT) of the chest is an independent risk factor for lung cancer.
The study used data from a prospective cohort of 1,166 former and current smokers participating in a lung cancer screening study. All individuals underwent a baseline LDCT and spirometry followed by yearly repeat LDCT studies. The incidence density of lung cancer among patients with and without emphysema on LDCT was estimated. Stratified and multiple regression analyses were used to assess whether emphysema is an independent risk factor for lung cancer after adjusting for age, gender, smoking history, and the presence of airway obstruction on spirometry.
On univariate analysis, the incidence density of lung cancer among individuals with and without emphysema on LDCT was 25.0 per 1,000 person-years and 7.5 per 1,000 person-years, respectively (risk ratio [RR], 3.33; 95% confidence interval [CI], 1.41 to 7.85). Emphysema was also associated with increased risk of lung cancer when the analysis was limited to individuals without airway obstruction on spirometry (RR, 4.33; 95% CI, 1.04 to 18.16). Multivariate analysis showed that the presence of emphysema (RR, 2.51; 95% CI, 1.01 to 6.23) on LDCT but not airway obstruction (RR, 2.10; 95% CI, 0.79 to 5.58) was associated with increased risk of lung cancer after adjusting for potential cofounders.
Results suggest that the presence of emphysema on LDCT is an independent risk factor for lung cancer.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>18079226</pmid><doi>10.1378/chest.07-1490</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Chest, 2007-12, Vol.132 (6), p.1932-1938 |
| issn | 0012-3692 1931-3543 |
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| subjects | airway obstruction Algorithms Biological and medical sciences Cardiology. Vascular system Chronic obstructive pulmonary disease, asthma emphysema Female Humans Incidence lung cancer Lung Neoplasms - diagnostic imaging Lung Neoplasms - epidemiology Lung Neoplasms - pathology Male Medical sciences Middle Aged Pneumology Poisson Distribution Prospective Studies Pulmonary Emphysema - diagnostic imaging Pulmonary Emphysema - epidemiology Pulmonary Emphysema - pathology Radiography, Thoracic Regression Analysis Risk Factors Smoking - epidemiology Spain - epidemiology Spirometry Surveys and Questionnaires Tomography, X-Ray Computed Tumors of the respiratory system and mediastinum |
| title | Assessing the Relationship Between Lung Cancer Risk and Emphysema Detected on Low-Dose CT of the Chest |
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