Transport of Alzheimer's associated amyloid-β catalyzed by P-glycoprotein

P-glycoprotein (P-gp) is a critical membrane transporter in the blood brain barrier (BBB) and is implicated in Alzheimer's disease (AD). However, previous studies on the ability of P-gp to directly transport the Alzheimer's associated amyloid-β (Aβ) protein have produced contradictory resu...

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Veröffentlicht in:	PloS one 2021-04, Vol.16 (4), p.e0250371
Hauptverfasser:	McCormick, James W, McCormick, Lauren, Chen, Gang, Vogel, Pia D, Wise, John G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Alzheimer Disease - metabolism Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - metabolism ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors ATP Binding Cassette Transporter, Subfamily B, Member 1 - chemistry ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism Biocatalysis Biology and Life Sciences Blood-Brain Barrier - metabolism Cell Line, Tumor Disease Progression Humans Hydrolysis Ligands Medicine and Health Sciences Molecular Docking Simulation Molecular Dynamics Simulation Peptide Fragments - chemistry Peptide Fragments - metabolism Physical Sciences Protein Binding Protein Conformation, beta-Strand Protein Domains Protein Transport Quinolines - pharmacology Research and Analysis Methods Signal Transduction - drug effects Substrate Specificity
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