Cell behavior on silica-hydroxyapatite coaxial composite
Progress in the manufacture of scaffolds in tissue engineering lies in the successful combination of materials such as bioceramics having properties as porosity, biocompatibility, water retention, protein adsorption, mechanical strength and biomineralization. Hydroxyapatite (HA) is a ceramic materia...
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| Veröffentlicht in: | PloS one 2021-05, Vol.16 (5), p.e0246256-e0246256 |
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| creator | Garibay-Alvarado, Jesús Alberto Herrera-Ríos, Ericka Berenice Vargas-Requena, Claudia Lucía de Jesús Ruíz-Baltazar, Álvaro Reyes-López, Simón Yobanny |
| description | Progress in the manufacture of scaffolds in tissue engineering lies in the successful combination of materials such as bioceramics having properties as porosity, biocompatibility, water retention, protein adsorption, mechanical strength and biomineralization. Hydroxyapatite (HA) is a ceramic material with lots of potential in tissue regeneration, however, its structural characteristics need to be improved for better performance. In this study, silica-hydroxyapatite (SiO2-HA) non-woven ceramic electrospunned membranes were prepared through the sol-gel method. Infrared spectra, scanning electron microscopy and XRD confirmed the structure and composition of composite. The obtained SiO2-HA polymeric fibers had approximately 230±20 nm in diameter and were then sintered at 800°C average diameter decreased to 110±17 nm. Three configurations of the membranes were obtained and tested in vitro, showing that the composite of SiO2-HA fibers showed a high percentage of viability on a fibroblast cell line. It is concluded that the fibers of SiO2-HA set in a coaxial configuration may be helpful to develop materials for bone regeneration. |
| doi_str_mv | 10.1371/journal.pone.0246256 |
| format | Article |
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It is concluded that the fibers of SiO2-HA set in a coaxial configuration may be helpful to develop materials for bone regeneration.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0246256</identifier><identifier>PMID: 33974626</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Antibacterial activity ; Bioceramics ; Biocompatibility ; Biology and Life Sciences ; Biomedical materials ; Bone regeneration ; Calcium phosphates ; Cell differentiation ; Ceramic fibers ; Composite materials ; Design and construction ; Editing ; Electron microscopy ; Engineering and Technology ; Ethanol ; Fourier analysis ; Fourier transforms ; Health aspects ; Hyaluronic acid ; Hydrogels ; Hydroxyapatite ; Infrared spectra ; Materials research ; Mechanical properties ; Medicine and Health Sciences ; Methodology ; Mineralization ; Nanoparticles ; Nitrates ; Optics ; Physical Sciences ; Platinum ; Porosity ; Protein adsorption ; Reflectance ; Research and analysis methods ; Reviews ; Scanning electron microscopy ; Silica ; Silicon dioxide ; Silk ; Silver ; Spectroscopy ; Spectrum analysis ; Structure ; Tissue engineering ; Wavelengths</subject><ispartof>PloS one, 2021-05, Vol.16 (5), p.e0246256-e0246256</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Garibay-Alvarado et al. 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It is concluded that the fibers of SiO2-HA set in a coaxial configuration may be helpful to develop materials for bone regeneration.</description><subject>Antibacterial activity</subject><subject>Bioceramics</subject><subject>Biocompatibility</subject><subject>Biology and Life Sciences</subject><subject>Biomedical materials</subject><subject>Bone regeneration</subject><subject>Calcium phosphates</subject><subject>Cell differentiation</subject><subject>Ceramic fibers</subject><subject>Composite materials</subject><subject>Design and construction</subject><subject>Editing</subject><subject>Electron microscopy</subject><subject>Engineering and Technology</subject><subject>Ethanol</subject><subject>Fourier analysis</subject><subject>Fourier transforms</subject><subject>Health aspects</subject><subject>Hyaluronic acid</subject><subject>Hydrogels</subject><subject>Hydroxyapatite</subject><subject>Infrared spectra</subject><subject>Materials research</subject><subject>Mechanical 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Hydroxyapatite (HA) is a ceramic material with lots of potential in tissue regeneration, however, its structural characteristics need to be improved for better performance. In this study, silica-hydroxyapatite (SiO2-HA) non-woven ceramic electrospunned membranes were prepared through the sol-gel method. Infrared spectra, scanning electron microscopy and XRD confirmed the structure and composition of composite. The obtained SiO2-HA polymeric fibers had approximately 230±20 nm in diameter and were then sintered at 800°C average diameter decreased to 110±17 nm. Three configurations of the membranes were obtained and tested in vitro, showing that the composite of SiO2-HA fibers showed a high percentage of viability on a fibroblast cell line. It is concluded that the fibers of SiO2-HA set in a coaxial configuration may be helpful to develop materials for bone regeneration.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33974626</pmid><doi>10.1371/journal.pone.0246256</doi><tpages>e0246256</tpages><orcidid>https://orcid.org/0000-0003-1032-3279</orcidid><orcidid>https://orcid.org/0000-0002-9017-3233</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Antibacterial activity Bioceramics Biocompatibility Biology and Life Sciences Biomedical materials Bone regeneration Calcium phosphates Cell differentiation Ceramic fibers Composite materials Design and construction Editing Electron microscopy Engineering and Technology Ethanol Fourier analysis Fourier transforms Health aspects Hyaluronic acid Hydrogels Hydroxyapatite Infrared spectra Materials research Mechanical properties Medicine and Health Sciences Methodology Mineralization Nanoparticles Nitrates Optics Physical Sciences Platinum Porosity Protein adsorption Reflectance Research and analysis methods Reviews Scanning electron microscopy Silica Silicon dioxide Silk Silver Spectroscopy Spectrum analysis Structure Tissue engineering Wavelengths |
| title | Cell behavior on silica-hydroxyapatite coaxial composite |
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