A biomathematical model of immune response and barrier function in mice with pneumococcal lung infection

Pneumonia is one of the leading causes of death worldwide. The course of the disease is often highly dynamic with unforeseen critical deterioration within hours in a relevant proportion of patients. Besides antibiotic treatment, novel adjunctive therapies are under development. Their additive value...

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Veröffentlicht in:	PloS one 2020-12, Vol.15 (12), p.e0243147
Hauptverfasser:	Schirm, Sibylle, Ahnert, Peter, Berger, Sarah, Nouailles, Geraldine, Wienhold, Sandra-Maria, Müller-Redetzky, Holger, Suttorp, Norbert, Loeffler, Markus, Witzenrath, Martin, Scholz, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Animals Anti-Bacterial Agents - therapeutic use Antibiotics Biology and Life Sciences Blood Bronchopulmonary infection Chemokines Complement C5a - antagonists & inhibitors Complement C5a - immunology Cytokines Differential equations Disease Models, Animal Drug dosages Epidemiology Fittings Health informatics Health services Hypotheses Immune response Immune system Immunity, Innate - drug effects Infectious diseases Inflammation Innate immunity Interleukin 10 Interleukin 6 Leukocytes (neutrophilic) Lung - drug effects Lung - immunology Lung diseases Lungs Macrophages Mathematical models Medicine and Health Sciences Mice Models, Immunological Monocyte chemoattractant protein 1 Monocytes Neutrophils Nonlinear equations Optimization Ordinary differential equations Parameters Peripheral blood Permeability Physiological aspects Pneumonia Pneumonia, Pneumococcal - drug therapy Pneumonia, Pneumococcal - immunology Schedules Streptococcus infections Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - immunology Therapy Time series
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