The female side of pharmacotherapy for ADHD-A systematic literature review
Objective This comprehensive review examined sex differences in prescription rates and efficacy or effectiveness of pharmacotherapy treatment in girls and women with attention deficit hyperactivity disorder (ADHD), while identifying gaps in the scientific knowledge on this topic. Method A rigorous e...
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| description | Objective This comprehensive review examined sex differences in prescription rates and efficacy or effectiveness of pharmacotherapy treatment in girls and women with attention deficit hyperactivity disorder (ADHD), while identifying gaps in the scientific knowledge on this topic. Method A rigorous electronic database search was carried out in order to identify all published studies on female-specific effects of stimulants and non-stimulants in the treatment of ADHD. In total, 2672 studies were screened of which 21 studies (seven on prescription rates, 14 on effects of pharmacotherapy) met the inclusion criteria and were included for analysis. Results In all seven studies on ADHD prescription rates, girls received significantly less prescriptions than boys, a difference however no longer seen in adults with the exception of one study. Each of the 14 studies on effectiveness / efficacy found at least one sex-difference in the effects of ADHD pharmacotherapy. Conclusion Several sex-differences are demonstrated in the prescription, usage and efficacy /effectiveness of both stimulant and non-stimulant ADHD pharmacotherapy. A single daily use of MPH may possibly not be optimal for girls with ADHD and ATX may be a promising medication for girls and women with ADHD. The robustness of this result requires further investigation. |
| doi_str_mv | 10.1371/journal.pone.0239257 |
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M. ; Tucha, Oliver</creator><contributor>Hutchinson, Gerard</contributor><creatorcontrib>Kok, Francien M. ; Groen, Yvonne ; Fuermaier, Anselm B. M. ; Tucha, Oliver ; Hutchinson, Gerard</creatorcontrib><description>Objective This comprehensive review examined sex differences in prescription rates and efficacy or effectiveness of pharmacotherapy treatment in girls and women with attention deficit hyperactivity disorder (ADHD), while identifying gaps in the scientific knowledge on this topic. Method A rigorous electronic database search was carried out in order to identify all published studies on female-specific effects of stimulants and non-stimulants in the treatment of ADHD. In total, 2672 studies were screened of which 21 studies (seven on prescription rates, 14 on effects of pharmacotherapy) met the inclusion criteria and were included for analysis. Results In all seven studies on ADHD prescription rates, girls received significantly less prescriptions than boys, a difference however no longer seen in adults with the exception of one study. Each of the 14 studies on effectiveness / efficacy found at least one sex-difference in the effects of ADHD pharmacotherapy. Conclusion Several sex-differences are demonstrated in the prescription, usage and efficacy /effectiveness of both stimulant and non-stimulant ADHD pharmacotherapy. A single daily use of MPH may possibly not be optimal for girls with ADHD and ATX may be a promising medication for girls and women with ADHD. The robustness of this result requires further investigation.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0239257</identifier><identifier>PMID: 32946507</identifier><language>eng</language><publisher>SAN FRANCISCO: Public Library Science</publisher><subject>Amphetamines ; Attention deficit hyperactivity disorder ; Biology and Life Sciences ; Children & youth ; Cognition & reasoning ; Drug dosages ; Drug therapy ; Effectiveness ; Females ; Gender aspects ; Gender differences ; Girls ; Health aspects ; Heart ; Hyperactivity ; Impulsivity ; Literature reviews ; Males ; Medicine and Health Sciences ; Multidisciplinary Sciences ; Neuropsychology ; Patient outcomes ; People and Places ; Pharmacology ; Prescriptions (Drugs) ; Psychiatric research ; Science & Technology ; Science & Technology - Other Topics ; Sex ; Sex differences ; Sex differences (Biology) ; Sexes ; Stimulants ; Systematic review ; Teenagers ; Women ; Women patients</subject><ispartof>PloS one, 2020-09, Vol.15 (9), p.e0239257-e0239257, Article 0239257</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Kok et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kok, Francien M.</au><au>Groen, Yvonne</au><au>Fuermaier, Anselm B. M.</au><au>Tucha, Oliver</au><au>Hutchinson, Gerard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The female side of pharmacotherapy for ADHD-A systematic literature review</atitle><jtitle>PloS one</jtitle><stitle>PLOS ONE</stitle><date>2020-09-18</date><risdate>2020</risdate><volume>15</volume><issue>9</issue><spage>e0239257</spage><epage>e0239257</epage><pages>e0239257-e0239257</pages><artnum>0239257</artnum><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Objective This comprehensive review examined sex differences in prescription rates and efficacy or effectiveness of pharmacotherapy treatment in girls and women with attention deficit hyperactivity disorder (ADHD), while identifying gaps in the scientific knowledge on this topic. Method A rigorous electronic database search was carried out in order to identify all published studies on female-specific effects of stimulants and non-stimulants in the treatment of ADHD. In total, 2672 studies were screened of which 21 studies (seven on prescription rates, 14 on effects of pharmacotherapy) met the inclusion criteria and were included for analysis. Results In all seven studies on ADHD prescription rates, girls received significantly less prescriptions than boys, a difference however no longer seen in adults with the exception of one study. Each of the 14 studies on effectiveness / efficacy found at least one sex-difference in the effects of ADHD pharmacotherapy. Conclusion Several sex-differences are demonstrated in the prescription, usage and efficacy /effectiveness of both stimulant and non-stimulant ADHD pharmacotherapy. A single daily use of MPH may possibly not be optimal for girls with ADHD and ATX may be a promising medication for girls and women with ADHD. The robustness of this result requires further investigation.</abstract><cop>SAN FRANCISCO</cop><pub>Public Library Science</pub><pmid>32946507</pmid><doi>10.1371/journal.pone.0239257</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0002-2331-0840</orcidid><orcidid>https://orcid.org/0000-0002-7242-0317</orcidid><orcidid>https://orcid.org/0000-0002-1000-0827</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Amphetamines Attention deficit hyperactivity disorder Biology and Life Sciences Children & youth Cognition & reasoning Drug dosages Drug therapy Effectiveness Females Gender aspects Gender differences Girls Health aspects Heart Hyperactivity Impulsivity Literature reviews Males Medicine and Health Sciences Multidisciplinary Sciences Neuropsychology Patient outcomes People and Places Pharmacology Prescriptions (Drugs) Psychiatric research Science & Technology Science & Technology - Other Topics Sex Sex differences Sex differences (Biology) Sexes Stimulants Systematic review Teenagers Women Women patients |
| title | The female side of pharmacotherapy for ADHD-A systematic literature review |
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