Bismuth Uptake in Rat Testicular Macrophages: A Follow-up Observation Suggesting that Bismuth Alters Interactions Between Testicular Macrophages and Leydig Cells
Recent studies suggest that bismuth accumulates in Leydig cells. In addition, a reduced level of serum testosterone and a statistically significant reduction of Leydig cells have been observed. It was therefore hypothesized that Bi has a direct toxic effect on rat Leydig cells. We have now developed...
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| Veröffentlicht in: | The journal of histochemistry and cytochemistry 2004-09, Vol.52 (9), p.1241-1243 |
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| container_title | The journal of histochemistry and cytochemistry |
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| creator | Stoltenberg, Meredin Hutson, James C |
| description | Recent studies suggest that bismuth accumulates in Leydig cells. In addition, a reduced level of serum testosterone and a statistically significant reduction of Leydig cells have been observed. It was therefore hypothesized that Bi has a direct toxic effect on rat Leydig cells. We have now developed a method for double labeling of bismuth and ED-2 (a marker for testicular macrophages). The present data demonstrate that the heavily bismuth-loaded cells in rat testis, originally interpreted as being Leydig cells, are bismuth-loaded macrophages. Consequently, our data suggest a modified hypothesis regarding bismuth-induced interactions between testicular macrophages and Leydig cells. |
| doi_str_mv | 10.1369/jhc.4B6286.2004 |
| format | Article |
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Consequently, our data suggest a modified hypothesis regarding bismuth-induced interactions between testicular macrophages and Leydig cells.</description><subject>Animals</subject><subject>Biological Transport</subject><subject>Bismuth - metabolism</subject><subject>Bismuth - pharmacology</subject><subject>Cell Adhesion - drug effects</subject><subject>Leydig Cells - cytology</subject><subject>Leydig Cells - drug effects</subject><subject>Macrophages - cytology</subject><subject>Macrophages - drug effects</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Testis - cytology</subject><issn>0022-1554</issn><issn>1551-5044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1u1DAURi1ERaeFNTvkFSsytR3bSdjNjChUmqpSadeW49z8DJ4ksh2iPg5vWo9SxIqurnR1vs--B6GPlKxpKourQ2vWfCtZLteMEP4GragQNBGE87doRQhjSVzwc3Th_YEQyrnI36FzKlLKSUFX6M-288cptPhxDPoX4K7H9zrgB_ChM5PVDt9q44ax1Q34r3iDrwdrhzmZRnxXenC_deiGHv-cmuYU6Rsc2pj_27qxAZzHN30c2pxQj7cQZoD-P29g3Vd4D09V1-AdWOvfo7NaWw8fXuYlerz-9rD7kezvvt_sNvvEcMJCksuc1qUEChqYTNMyr4uyzDNNDWO6NBmXGc1IlRVM1FBlTEheCpMZluqMGZleoqulN37Fewe1Gl131O5JUaJOslWUrRbZ6iQ7Jj4tiXEqj1D941_sRuDLAvh4mToMk-vjBa_0fV7wtmvauXOg_FFbG9upmudZMFUoyjhNnwFA5pkw</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Stoltenberg, Meredin</creator><creator>Hutson, James C</creator><general>Histochemical Soc</general><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20040901</creationdate><title>Bismuth Uptake in Rat Testicular Macrophages: A Follow-up Observation Suggesting that Bismuth Alters Interactions Between Testicular Macrophages and Leydig Cells</title><author>Stoltenberg, Meredin ; Hutson, James C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-8681fb6e1eae2633b8f9bb87a1c22abc7467170d7925fed72564b5c7c23a72c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological Transport</topic><topic>Bismuth - metabolism</topic><topic>Bismuth - pharmacology</topic><topic>Cell Adhesion - drug effects</topic><topic>Leydig Cells - cytology</topic><topic>Leydig Cells - drug effects</topic><topic>Macrophages - cytology</topic><topic>Macrophages - drug effects</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Testis - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stoltenberg, Meredin</creatorcontrib><creatorcontrib>Hutson, James C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The journal of histochemistry and cytochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stoltenberg, Meredin</au><au>Hutson, James C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bismuth Uptake in Rat Testicular Macrophages: A Follow-up Observation Suggesting that Bismuth Alters Interactions Between Testicular Macrophages and Leydig Cells</atitle><jtitle>The journal of histochemistry and cytochemistry</jtitle><addtitle>J Histochem Cytochem</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>52</volume><issue>9</issue><spage>1241</spage><epage>1243</epage><pages>1241-1243</pages><issn>0022-1554</issn><eissn>1551-5044</eissn><abstract>Recent studies suggest that bismuth accumulates in Leydig cells. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SAGE Complete; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Biological Transport Bismuth - metabolism Bismuth - pharmacology Cell Adhesion - drug effects Leydig Cells - cytology Leydig Cells - drug effects Macrophages - cytology Macrophages - drug effects Male Rats Rats, Wistar Testis - cytology |
| title | Bismuth Uptake in Rat Testicular Macrophages: A Follow-up Observation Suggesting that Bismuth Alters Interactions Between Testicular Macrophages and Leydig Cells |
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