Surface-Enhanced Raman Spectra of VX and its Hydrolysis Products
Detection of chemical agents as poisons in water supplies not only requires μg/L sensitivity, but also requires the ability to distinguish their hydrolysis products. We have been investigating the ability of surface-enhanced Raman spectroscopy (SERS) to detect chemical agents at these concentrations...
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| Veröffentlicht in: | Applied spectroscopy 2005-05, Vol.59 (5), p.654-660 |
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| creator | Farquharson, Stuart Gift, Alan Maksymiuk, Paul Inscore, Frank |
| description | Detection of chemical agents as poisons in water supplies not only requires μg/L sensitivity, but also requires the ability to distinguish their hydrolysis products. We have been investigating the ability of surface-enhanced Raman spectroscopy (SERS) to detect chemical agents at these concentrations. Here we expand these studies and present the SERS spectra of the nerve agent VX (ethyl S-2-diisopropylamino ethyl methylphosphonothioate) and its hydrolysis products, ethyl S-2-diisopropylamino methylphosphonothioate, 2-(diisopropylamino) ethanethiol, ethyl methylphosphonic acid, and methylphosphonic acid. Vibrational mode assignments for the observed SERS peaks are also provided. Overall, each of these chemicals produces a series of peaks between 450 and 900 cm−1 that are sufficiently unique to allow identification. SERS measurements were performed in silver-doped sol-gel-filled capillaries that are being developed as part of an extractive point sensor. |
| doi_str_mv | 10.1366/0003702053946100 |
| format | Article |
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We have been investigating the ability of surface-enhanced Raman spectroscopy (SERS) to detect chemical agents at these concentrations. Here we expand these studies and present the SERS spectra of the nerve agent VX (ethyl S-2-diisopropylamino ethyl methylphosphonothioate) and its hydrolysis products, ethyl S-2-diisopropylamino methylphosphonothioate, 2-(diisopropylamino) ethanethiol, ethyl methylphosphonic acid, and methylphosphonic acid. Vibrational mode assignments for the observed SERS peaks are also provided. Overall, each of these chemicals produces a series of peaks between 450 and 900 cm−1 that are sufficiently unique to allow identification. 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SERS measurements were performed in silver-doped sol-gel-filled capillaries that are being developed as part of an extractive point sensor.</description><subject>Chemical Warfare Agents - analysis</subject><subject>Chemical Warfare Agents - chemistry</subject><subject>Environmental Monitoring - methods</subject><subject>Hydrolysis</subject><subject>Organophosphorus Compounds - analysis</subject><subject>Organophosphorus Compounds - chemistry</subject><subject>Organothiophosphorus Compounds - analysis</subject><subject>Organothiophosphorus Compounds - chemistry</subject><subject>Spectrum Analysis, Raman - methods</subject><subject>Sulfhydryl Compounds - analysis</subject><subject>Sulfhydryl Compounds - chemistry</subject><subject>Water Pollutants, Chemical - analysis</subject><subject>Water Pollution - prevention & control</subject><issn>0003-7028</issn><issn>1943-3530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UMtKAzEUDaLYWt27kvxA9GbymGSnlNYKBcWquBvSPLSlnSnJzGL-3pQWBMHF5XA5DzgHoWsKt5RJeQcArIQCBNNcUoATNKSaM8IEg1M03NMk82qALlJa51doJs7RgAottaJ0iO4XXQzGejKpv01tvcOvZmtqvNh520aDm4A_PrGpHV61Cc96F5tNn1YJv8TGdbZNl-gsmE3yV0ccoffp5G08I_Pnx6fxw5xYDrQlIgjLtQImCkUzCmEKESjjBTijlAu6UPkELUupqHBSO5ChVJpzHZbashGCQ66NTUrRh2oXV1sT-4pCtR-j-jtGttwcLLtuufXu13BsnwXkIEjmy1frpot1rvB_4A-yEWPL</recordid><startdate>200505</startdate><enddate>200505</enddate><creator>Farquharson, Stuart</creator><creator>Gift, Alan</creator><creator>Maksymiuk, Paul</creator><creator>Inscore, Frank</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200505</creationdate><title>Surface-Enhanced Raman Spectra of VX and its Hydrolysis Products</title><author>Farquharson, Stuart ; Gift, Alan ; Maksymiuk, Paul ; Inscore, Frank</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-5f5c49803528198055a25f13420da88df928f9251776815d69d06f789449fb9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Chemical Warfare Agents - analysis</topic><topic>Chemical Warfare Agents - chemistry</topic><topic>Environmental Monitoring - methods</topic><topic>Hydrolysis</topic><topic>Organophosphorus Compounds - analysis</topic><topic>Organophosphorus Compounds - chemistry</topic><topic>Organothiophosphorus Compounds - analysis</topic><topic>Organothiophosphorus Compounds - chemistry</topic><topic>Spectrum Analysis, Raman - methods</topic><topic>Sulfhydryl Compounds - analysis</topic><topic>Sulfhydryl Compounds - chemistry</topic><topic>Water Pollutants, Chemical - analysis</topic><topic>Water Pollution - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farquharson, Stuart</creatorcontrib><creatorcontrib>Gift, Alan</creatorcontrib><creatorcontrib>Maksymiuk, Paul</creatorcontrib><creatorcontrib>Inscore, Frank</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Applied spectroscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farquharson, Stuart</au><au>Gift, Alan</au><au>Maksymiuk, Paul</au><au>Inscore, Frank</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surface-Enhanced Raman Spectra of VX and its Hydrolysis Products</atitle><jtitle>Applied spectroscopy</jtitle><addtitle>Appl Spectrosc</addtitle><date>2005-05</date><risdate>2005</risdate><volume>59</volume><issue>5</issue><spage>654</spage><epage>660</epage><pages>654-660</pages><issn>0003-7028</issn><eissn>1943-3530</eissn><abstract>Detection of chemical agents as poisons in water supplies not only requires μg/L sensitivity, but also requires the ability to distinguish their hydrolysis products. 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| ispartof | Applied spectroscopy, 2005-05, Vol.59 (5), p.654-660 |
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| source | MEDLINE; SAGE Complete |
| subjects | Chemical Warfare Agents - analysis Chemical Warfare Agents - chemistry Environmental Monitoring - methods Hydrolysis Organophosphorus Compounds - analysis Organophosphorus Compounds - chemistry Organothiophosphorus Compounds - analysis Organothiophosphorus Compounds - chemistry Spectrum Analysis, Raman - methods Sulfhydryl Compounds - analysis Sulfhydryl Compounds - chemistry Water Pollutants, Chemical - analysis Water Pollution - prevention & control |
| title | Surface-Enhanced Raman Spectra of VX and its Hydrolysis Products |
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