Minocycline-induced pericardial effusion
OBJECTIVE: To describe a reversible hypersensitivity reaction characterized by pericardial effusion and acute mixed liver injury in a woman treated with minocycline. CASE SUMMARY: A 39-year-old white woman developed dyspnea and chest pain with pericardial effusion on echocardiography approximately 2...
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Veröffentlicht in: | The Annals of pharmacotherapy 2000-07, Vol.34 (7), p.875-877 |
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creator | Christe, C Ricou, F Stoller, R Vogt, N |
description | OBJECTIVE:
To describe a reversible hypersensitivity reaction characterized by pericardial effusion and acute mixed liver injury in a woman treated with minocycline.
CASE SUMMARY:
A 39-year-old white woman developed dyspnea and chest pain with pericardial effusion on echocardiography approximately 20 days after starting minocycline treatment. Additional manifestations consisted of eosinophilia and liver injury. No lung, skin, or joint involvement was noted; antinuclear antibody testing was negative.
DISCUSSION:
Minocycline has been associated with rare but severe hypersensitivity reactions and autoimmune disorders, generally involving the lungs, skin, or joints. We observed a patient with an unusual minocycline-induced reaction with pericardial effusion and acute mixed liver injury. The number of spontaneously reported cases in national and international databases indicates that minocycline-induced pericardial effusion is very rare as a main clinical manifestation.
CONCLUSIONS:
Clinicians should be aware of the possibility of pericardial effusion without lung, skin, or joint involvement as an adverse effect of minocycline. |
doi_str_mv | 10.1345/aph.19386 |
format | Article |
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To describe a reversible hypersensitivity reaction characterized by pericardial effusion and acute mixed liver injury in a woman treated with minocycline.
CASE SUMMARY:
A 39-year-old white woman developed dyspnea and chest pain with pericardial effusion on echocardiography approximately 20 days after starting minocycline treatment. Additional manifestations consisted of eosinophilia and liver injury. No lung, skin, or joint involvement was noted; antinuclear antibody testing was negative.
DISCUSSION:
Minocycline has been associated with rare but severe hypersensitivity reactions and autoimmune disorders, generally involving the lungs, skin, or joints. We observed a patient with an unusual minocycline-induced reaction with pericardial effusion and acute mixed liver injury. The number of spontaneously reported cases in national and international databases indicates that minocycline-induced pericardial effusion is very rare as a main clinical manifestation.
CONCLUSIONS:
Clinicians should be aware of the possibility of pericardial effusion without lung, skin, or joint involvement as an adverse effect of minocycline.</description><identifier>ISSN: 1060-0280</identifier><identifier>EISSN: 1542-6270</identifier><identifier>DOI: 10.1345/aph.19386</identifier><identifier>PMID: 10928400</identifier><identifier>CODEN: APHRER</identifier><language>eng</language><publisher>Cincinnati, OH: Harvey Whitney Books</publisher><subject>Acne Vulgaris - drug therapy ; Acute Disease ; Adult ; Anti-Bacterial Agents - adverse effects ; Anti-Bacterial Agents - therapeutic use ; Biological and medical sciences ; Chemical and Drug Induced Liver Injury ; Drug toxicity and drugs side effects treatment ; Echocardiography ; Female ; Humans ; Medical sciences ; Minocycline - adverse effects ; Minocycline - therapeutic use ; Pericardial Effusion - chemically induced ; Pericardial Effusion - diagnosis ; Pharmacology. Drug treatments ; Toxicity: cardiovascular system</subject><ispartof>The Annals of pharmacotherapy, 2000-07, Vol.34 (7), p.875-877</ispartof><rights>2000 SAGE Publications</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-be5fe62e77bf1c5337d3c36afcec3b7cbec8cc9fbcd86f1226bab0d28f7e702e3</citedby><cites>FETCH-LOGICAL-c371t-be5fe62e77bf1c5337d3c36afcec3b7cbec8cc9fbcd86f1226bab0d28f7e702e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1345/aph.19386$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1345/aph.19386$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21818,27923,27924,43620,43621</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1447761$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10928400$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Christe, C</creatorcontrib><creatorcontrib>Ricou, F</creatorcontrib><creatorcontrib>Stoller, R</creatorcontrib><creatorcontrib>Vogt, N</creatorcontrib><title>Minocycline-induced pericardial effusion</title><title>The Annals of pharmacotherapy</title><addtitle>Ann Pharmacother</addtitle><description>OBJECTIVE:
To describe a reversible hypersensitivity reaction characterized by pericardial effusion and acute mixed liver injury in a woman treated with minocycline.
CASE SUMMARY:
A 39-year-old white woman developed dyspnea and chest pain with pericardial effusion on echocardiography approximately 20 days after starting minocycline treatment. Additional manifestations consisted of eosinophilia and liver injury. No lung, skin, or joint involvement was noted; antinuclear antibody testing was negative.
DISCUSSION:
Minocycline has been associated with rare but severe hypersensitivity reactions and autoimmune disorders, generally involving the lungs, skin, or joints. We observed a patient with an unusual minocycline-induced reaction with pericardial effusion and acute mixed liver injury. The number of spontaneously reported cases in national and international databases indicates that minocycline-induced pericardial effusion is very rare as a main clinical manifestation.
CONCLUSIONS:
Clinicians should be aware of the possibility of pericardial effusion without lung, skin, or joint involvement as an adverse effect of minocycline.</description><subject>Acne Vulgaris - drug therapy</subject><subject>Acute Disease</subject><subject>Adult</subject><subject>Anti-Bacterial Agents - adverse effects</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Chemical and Drug Induced Liver Injury</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Minocycline - adverse effects</subject><subject>Minocycline - therapeutic use</subject><subject>Pericardial Effusion - chemically induced</subject><subject>Pericardial Effusion - diagnosis</subject><subject>Pharmacology. Drug treatments</subject><subject>Toxicity: cardiovascular system</subject><issn>1060-0280</issn><issn>1542-6270</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptzz1PwzAQgGELgWgpDPwB1AEQDCn-SOxkRBVfUhELzJZ9Obeu0qSyiaL-ewKpBAPT3fDoTi8h54zOmEizO7NdzVghcnlAxixLeSK5oof9TiVNKM_piJzEuKaUFowXx2TEaMHzlNIxuXn1dQM7qHyNia_LFrCcbjF4MKH0ppqic230TX1KjpypIp7t54R8PD68z5-TxdvTy_x-kYBQ7DOxmDmUHJWyjkEmhCoFCGkcIAirwCLkAIWzUObSMc6lNZaWPHcKFeUoJuR2uAuhiTGg09vgNybsNKP6u1b3tfqntrcXg922doPlHznk9eByD0wEU7lgavDx16WpUpL17Hpg0SxRr5s21H3ivw-vBrjyy1XnA-q4MVXVv2e66zqRaqVzlYkv4TB23A</recordid><startdate>20000701</startdate><enddate>20000701</enddate><creator>Christe, C</creator><creator>Ricou, F</creator><creator>Stoller, R</creator><creator>Vogt, N</creator><general>Harvey Whitney Books</general><general>SAGE Publications</general><general>Whitney</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20000701</creationdate><title>Minocycline-induced pericardial effusion</title><author>Christe, C ; Ricou, F ; Stoller, R ; Vogt, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-be5fe62e77bf1c5337d3c36afcec3b7cbec8cc9fbcd86f1226bab0d28f7e702e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Acne Vulgaris - drug therapy</topic><topic>Acute Disease</topic><topic>Adult</topic><topic>Anti-Bacterial Agents - adverse effects</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Chemical and Drug Induced Liver Injury</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Minocycline - adverse effects</topic><topic>Minocycline - therapeutic use</topic><topic>Pericardial Effusion - chemically induced</topic><topic>Pericardial Effusion - diagnosis</topic><topic>Pharmacology. Drug treatments</topic><topic>Toxicity: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Christe, C</creatorcontrib><creatorcontrib>Ricou, F</creatorcontrib><creatorcontrib>Stoller, R</creatorcontrib><creatorcontrib>Vogt, N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The Annals of pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Christe, C</au><au>Ricou, F</au><au>Stoller, R</au><au>Vogt, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Minocycline-induced pericardial effusion</atitle><jtitle>The Annals of pharmacotherapy</jtitle><addtitle>Ann Pharmacother</addtitle><date>2000-07-01</date><risdate>2000</risdate><volume>34</volume><issue>7</issue><spage>875</spage><epage>877</epage><pages>875-877</pages><issn>1060-0280</issn><eissn>1542-6270</eissn><coden>APHRER</coden><abstract>OBJECTIVE:
To describe a reversible hypersensitivity reaction characterized by pericardial effusion and acute mixed liver injury in a woman treated with minocycline.
CASE SUMMARY:
A 39-year-old white woman developed dyspnea and chest pain with pericardial effusion on echocardiography approximately 20 days after starting minocycline treatment. Additional manifestations consisted of eosinophilia and liver injury. No lung, skin, or joint involvement was noted; antinuclear antibody testing was negative.
DISCUSSION:
Minocycline has been associated with rare but severe hypersensitivity reactions and autoimmune disorders, generally involving the lungs, skin, or joints. We observed a patient with an unusual minocycline-induced reaction with pericardial effusion and acute mixed liver injury. The number of spontaneously reported cases in national and international databases indicates that minocycline-induced pericardial effusion is very rare as a main clinical manifestation.
CONCLUSIONS:
Clinicians should be aware of the possibility of pericardial effusion without lung, skin, or joint involvement as an adverse effect of minocycline.</abstract><cop>Cincinnati, OH</cop><pub>Harvey Whitney Books</pub><pmid>10928400</pmid><doi>10.1345/aph.19386</doi><tpages>3</tpages></addata></record> |
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subjects | Acne Vulgaris - drug therapy Acute Disease Adult Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - therapeutic use Biological and medical sciences Chemical and Drug Induced Liver Injury Drug toxicity and drugs side effects treatment Echocardiography Female Humans Medical sciences Minocycline - adverse effects Minocycline - therapeutic use Pericardial Effusion - chemically induced Pericardial Effusion - diagnosis Pharmacology. Drug treatments Toxicity: cardiovascular system |
title | Minocycline-induced pericardial effusion |
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