Factors Associated with Preventability, Predictability, and Severity of Adverse Drug Reactions
OBJECTIVE: To determine the rate of adverse drug reactions (ADRs) in hospitalized patients in an Iranian hospital and to assess factors associated with preventability, predictability, and severity of ADRs. DESIGN AND PARTICIPANTS: A prospective, randomized study was conducted on 370 patients in a ho...
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| Veröffentlicht in: | The Annals of pharmacotherapy 1999-02, Vol.33 (2), p.236-240 |
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| container_title | The Annals of pharmacotherapy |
| container_volume | 33 |
| creator | Gholami, Kheirollah Shalviri, Gloria |
| description | OBJECTIVE:
To determine the rate of adverse drug reactions (ADRs) in hospitalized patients in an Iranian hospital and to assess factors associated with preventability, predictability, and severity of ADRs.
DESIGN AND PARTICIPANTS:
A prospective, randomized study was conducted on 370 patients in a hospital at the Tehran Medical Sciences University, from March to December 1996. Patients who experienced at least one ADR (n = 62) were entered into the database. Preventability, predictability, and severity of reactions were determined, based on the available algorithms developed by other investigators.
SETTING:
A 1200-bed tertiary care university teaching hospital in Tehran, Iran.
RESULTS:
Approximately 16.8% (n = 62) of the 370 patients who were included in this study had at least one ADR. One hundred two ADRs were reported during this study. Approximately 58.8% of the ADRs (60 reactions) were identified as preventable reactions and 96.1% as predictable reactions. The severity of 9.8% of the ADRs was identified as mild, 86.3% as moderate, 1% as severe, and 2.9% as lethal. The length of hospitalization increased with the severity of the ADRs. Preventable ADRs were more severe than those that were nonpreventable. In addition, the incidence of preventable ADRs increased with the patients' age and caused longer hospitalization than did nonpreventable ones. The most predictable ADRs were hematologic.
CONCLUSIONS:
This study noted that the rate of ADRs in Iran is probably as high as the rate in other parts of the world. These results indicate a need for a strong national ADR program that detects and reports adverse drug events in Iran. |
| doi_str_mv | 10.1345/aph.17440 |
| format | Article |
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To determine the rate of adverse drug reactions (ADRs) in hospitalized patients in an Iranian hospital and to assess factors associated with preventability, predictability, and severity of ADRs.
DESIGN AND PARTICIPANTS:
A prospective, randomized study was conducted on 370 patients in a hospital at the Tehran Medical Sciences University, from March to December 1996. Patients who experienced at least one ADR (n = 62) were entered into the database. Preventability, predictability, and severity of reactions were determined, based on the available algorithms developed by other investigators.
SETTING:
A 1200-bed tertiary care university teaching hospital in Tehran, Iran.
RESULTS:
Approximately 16.8% (n = 62) of the 370 patients who were included in this study had at least one ADR. One hundred two ADRs were reported during this study. Approximately 58.8% of the ADRs (60 reactions) were identified as preventable reactions and 96.1% as predictable reactions. The severity of 9.8% of the ADRs was identified as mild, 86.3% as moderate, 1% as severe, and 2.9% as lethal. The length of hospitalization increased with the severity of the ADRs. Preventable ADRs were more severe than those that were nonpreventable. In addition, the incidence of preventable ADRs increased with the patients' age and caused longer hospitalization than did nonpreventable ones. The most predictable ADRs were hematologic.
CONCLUSIONS:
This study noted that the rate of ADRs in Iran is probably as high as the rate in other parts of the world. These results indicate a need for a strong national ADR program that detects and reports adverse drug events in Iran.</description><identifier>ISSN: 1060-0280</identifier><identifier>EISSN: 1542-6270</identifier><identifier>DOI: 10.1345/aph.17440</identifier><identifier>PMID: 10084421</identifier><identifier>CODEN: APHRER</identifier><language>eng</language><publisher>Cincinnati, OH: SAGE Publications</publisher><subject>Adolescent ; Adult ; Adverse Drug Reaction Reporting Systems - classification ; Adverse Drug Reaction Reporting Systems - organization & administration ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Chi-Square Distribution ; Child ; Clinical trial. Drug monitoring ; Drug Monitoring - methods ; Female ; General pharmacology ; Hospital Bed Capacity, 500 and over ; Hospitalization ; Hospitals, University ; Humans ; Iran - epidemiology ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Prospective Studies ; Quality Assurance, Health Care</subject><ispartof>The Annals of pharmacotherapy, 1999-02, Vol.33 (2), p.236-240</ispartof><rights>1999 SAGE Publications</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c341t-772fe6d9eea2ce5c1b2d6e1a1e3d15f41b4a91edf5d645ab378303427b43f76c3</citedby><cites>FETCH-LOGICAL-c341t-772fe6d9eea2ce5c1b2d6e1a1e3d15f41b4a91edf5d645ab378303427b43f76c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1345/aph.17440$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1345/aph.17440$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21818,27923,27924,43620,43621</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1708420$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10084421$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gholami, Kheirollah</creatorcontrib><creatorcontrib>Shalviri, Gloria</creatorcontrib><title>Factors Associated with Preventability, Predictability, and Severity of Adverse Drug Reactions</title><title>The Annals of pharmacotherapy</title><addtitle>Ann Pharmacother</addtitle><description>OBJECTIVE:
To determine the rate of adverse drug reactions (ADRs) in hospitalized patients in an Iranian hospital and to assess factors associated with preventability, predictability, and severity of ADRs.
DESIGN AND PARTICIPANTS:
A prospective, randomized study was conducted on 370 patients in a hospital at the Tehran Medical Sciences University, from March to December 1996. Patients who experienced at least one ADR (n = 62) were entered into the database. Preventability, predictability, and severity of reactions were determined, based on the available algorithms developed by other investigators.
SETTING:
A 1200-bed tertiary care university teaching hospital in Tehran, Iran.
RESULTS:
Approximately 16.8% (n = 62) of the 370 patients who were included in this study had at least one ADR. One hundred two ADRs were reported during this study. Approximately 58.8% of the ADRs (60 reactions) were identified as preventable reactions and 96.1% as predictable reactions. The severity of 9.8% of the ADRs was identified as mild, 86.3% as moderate, 1% as severe, and 2.9% as lethal. The length of hospitalization increased with the severity of the ADRs. Preventable ADRs were more severe than those that were nonpreventable. In addition, the incidence of preventable ADRs increased with the patients' age and caused longer hospitalization than did nonpreventable ones. The most predictable ADRs were hematologic.
CONCLUSIONS:
This study noted that the rate of ADRs in Iran is probably as high as the rate in other parts of the world. These results indicate a need for a strong national ADR program that detects and reports adverse drug events in Iran.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adverse Drug Reaction Reporting Systems - classification</subject><subject>Adverse Drug Reaction Reporting Systems - organization & administration</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Chi-Square Distribution</subject><subject>Child</subject><subject>Clinical trial. Drug monitoring</subject><subject>Drug Monitoring - methods</subject><subject>Female</subject><subject>General pharmacology</subject><subject>Hospital Bed Capacity, 500 and over</subject><subject>Hospitalization</subject><subject>Hospitals, University</subject><subject>Humans</subject><subject>Iran - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><subject>Quality Assurance, Health Care</subject><issn>1060-0280</issn><issn>1542-6270</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1LAzEQhoMotlYP_gHJQQTBrfnaTfdYqlWhoPhxdckmkzal3S3JVum_N3UL9eBp5oWHd5gHoXNK-pSL9FatZn0qhSAHqEtTwZKMSXIYd5KRhLAB6aCTEOaEkJyy_Bh1KCEDIRjtos-x0k3tAx6GUGunGjD42zUz_OLhC6pGlW7hms3NNhun91lVBr9FxMeEa4uHJu4B8J1fT_ErxFZXV-EUHVm1CHC2mz30Mb5_Hz0mk-eHp9FwkmguaJNIySxkJgdQTEOqaclMBlRR4IamVtBSqJyCsanJRKpKLgeccMFkKbiVmeY9dN32al-H4MEWK--Wym8KSoqtoyI6Kn4dRfaiZVfrcgnmD9lKicDlDlBBq4X1qtIu7DkZObbtuWqxoKZQzOu1r-KL_xz8AUc1e_c</recordid><startdate>19990201</startdate><enddate>19990201</enddate><creator>Gholami, Kheirollah</creator><creator>Shalviri, Gloria</creator><general>SAGE Publications</general><general>Whitney</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19990201</creationdate><title>Factors Associated with Preventability, Predictability, and Severity of Adverse Drug Reactions</title><author>Gholami, Kheirollah ; Shalviri, Gloria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-772fe6d9eea2ce5c1b2d6e1a1e3d15f41b4a91edf5d645ab378303427b43f76c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adverse Drug Reaction Reporting Systems - classification</topic><topic>Adverse Drug Reaction Reporting Systems - organization & administration</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Chi-Square Distribution</topic><topic>Child</topic><topic>Clinical trial. Drug monitoring</topic><topic>Drug Monitoring - methods</topic><topic>Female</topic><topic>General pharmacology</topic><topic>Hospital Bed Capacity, 500 and over</topic><topic>Hospitalization</topic><topic>Hospitals, University</topic><topic>Humans</topic><topic>Iran - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Prospective Studies</topic><topic>Quality Assurance, Health Care</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gholami, Kheirollah</creatorcontrib><creatorcontrib>Shalviri, Gloria</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The Annals of pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gholami, Kheirollah</au><au>Shalviri, Gloria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors Associated with Preventability, Predictability, and Severity of Adverse Drug Reactions</atitle><jtitle>The Annals of pharmacotherapy</jtitle><addtitle>Ann Pharmacother</addtitle><date>1999-02-01</date><risdate>1999</risdate><volume>33</volume><issue>2</issue><spage>236</spage><epage>240</epage><pages>236-240</pages><issn>1060-0280</issn><eissn>1542-6270</eissn><coden>APHRER</coden><abstract>OBJECTIVE:
To determine the rate of adverse drug reactions (ADRs) in hospitalized patients in an Iranian hospital and to assess factors associated with preventability, predictability, and severity of ADRs.
DESIGN AND PARTICIPANTS:
A prospective, randomized study was conducted on 370 patients in a hospital at the Tehran Medical Sciences University, from March to December 1996. Patients who experienced at least one ADR (n = 62) were entered into the database. Preventability, predictability, and severity of reactions were determined, based on the available algorithms developed by other investigators.
SETTING:
A 1200-bed tertiary care university teaching hospital in Tehran, Iran.
RESULTS:
Approximately 16.8% (n = 62) of the 370 patients who were included in this study had at least one ADR. One hundred two ADRs were reported during this study. Approximately 58.8% of the ADRs (60 reactions) were identified as preventable reactions and 96.1% as predictable reactions. The severity of 9.8% of the ADRs was identified as mild, 86.3% as moderate, 1% as severe, and 2.9% as lethal. The length of hospitalization increased with the severity of the ADRs. Preventable ADRs were more severe than those that were nonpreventable. In addition, the incidence of preventable ADRs increased with the patients' age and caused longer hospitalization than did nonpreventable ones. The most predictable ADRs were hematologic.
CONCLUSIONS:
This study noted that the rate of ADRs in Iran is probably as high as the rate in other parts of the world. These results indicate a need for a strong national ADR program that detects and reports adverse drug events in Iran.</abstract><cop>Cincinnati, OH</cop><pub>SAGE Publications</pub><pmid>10084421</pmid><doi>10.1345/aph.17440</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1060-0280 |
| ispartof | The Annals of pharmacotherapy, 1999-02, Vol.33 (2), p.236-240 |
| issn | 1060-0280 1542-6270 |
| language | eng |
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| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Adolescent Adult Adverse Drug Reaction Reporting Systems - classification Adverse Drug Reaction Reporting Systems - organization & administration Aged Aged, 80 and over Biological and medical sciences Chi-Square Distribution Child Clinical trial. Drug monitoring Drug Monitoring - methods Female General pharmacology Hospital Bed Capacity, 500 and over Hospitalization Hospitals, University Humans Iran - epidemiology Male Medical sciences Middle Aged Pharmacology. Drug treatments Prospective Studies Quality Assurance, Health Care |
| title | Factors Associated with Preventability, Predictability, and Severity of Adverse Drug Reactions |
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