Epithelioid Sarcoma

Epithelioid Sarcoma

Epithelioid sarcoma (ES) is rare with a poor prognosis and for which a loss of INI1 expression has been recently reported. We report a study of 106 cases with clinical, histologic, and immunohistochemical data, including INI1 expression, and follow-up data. Of the 106 cases, 70 were the conventional...

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Veröffentlicht in:American journal of clinical pathology 2009-02, Vol.131 (2), p.222-227
Hauptverfasser: Chbani, Laila, Guillou, Louis, Terrier, Philippe, Decouvelaere, Anne Valérie, Grégoire, Fleur, Terrier-Lacombe, Marie José, Ranchère, Dominique, Robin, Yves Marie, Collin, Françoise, Fréneaux, Paul, Coindre, Jean-Michel
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container_issue 2
container_start_page 222
container_title American journal of clinical pathology
container_volume 131
creator Chbani, Laila
Guillou, Louis
Terrier, Philippe
Decouvelaere, Anne Valérie
Grégoire, Fleur
Terrier-Lacombe, Marie José
Ranchère, Dominique
Robin, Yves Marie
Collin, Françoise
Fréneaux, Paul
Coindre, Jean-Michel
description Epithelioid sarcoma (ES) is rare with a poor prognosis and for which a loss of INI1 expression has been recently reported. We report a study of 106 cases with clinical, histologic, and immunohistochemical data, including INI1 expression, and follow-up data. Of the 106 cases, 70 were the conventional subtype and 36 the large cell subtype. INI1 was negative in 86 cases (81.1%): 57 (81%) of 70 conventional and 29 (81%) of 36 large cell subtypes. Treatment modalities were available for 76 and follow-up for 80 patients. Of the 80 patients, 43 (54%) experienced metastasis and 25 (31%) died of the disease. Univariate analysis indicated that tumor size and mitotic index were significant for metastasis-free survival, whereas proximal location, tumor size, tumor multifocality, and mitotic index were significant for overall survival. Loss of expression of INI1 is frequent in the conventional and large cell subtypes of ES and can be used as a diagnostic marker, but it has no prognostic impact.
doi_str_mv 10.1309/AJCPU98ABIPVJAIV
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title Epithelioid Sarcoma
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