Spontaneous extraskeletal osteosarcoma in the neck skeletal muscle of a Crlj:CD1 (ICR) mouse
Extraskeletal osteosarcoma is extremely rare in humans and animals, especially in rodents. This is the first case report on spontaneous extraskeletal osteosarcoma in the neck skeletal muscle of a Crlj:CD1 (ICR) mouse (36 weeks, dead). Necropsy revealed a solid white mass located in the neck skeletal...
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| Veröffentlicht in: | Journal of Toxicologic Pathology 2021, Vol.34(2), pp.147-150 |
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| creator | Ibi, Kanata Chiba, Shiori Koyama, Naomi Hashimoto, Kazuto Nejishima, Hiroaki |
| description | Extraskeletal osteosarcoma is extremely rare in humans and animals, especially in rodents. This is the first case report on spontaneous extraskeletal osteosarcoma in the neck skeletal muscle of a Crlj:CD1 (ICR) mouse (36 weeks, dead). Necropsy revealed a solid white mass located in the neck skeletal muscle (scalenus muscle). Histological examination showed that the tumor consisted of atypical polygonal cells, a small osteoid clump, and bone tissue. Mitotic figures were observed. Serial sections showed that neoplastic cells lacked clear invasive proliferation to adjacent normal skeletal muscle and continuity with normal bone tissue. Immunohistochemical analysis showed that the neoplastic cells were positive for osteocalcin, osterix, vimentin, and S-100. Based on these results, the tumor was diagnosed as extraskeletal osteosarcoma in the neck skeletal muscle. |
| doi_str_mv | 10.1293/tox.2020-0083 |
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This is the first case report on spontaneous extraskeletal osteosarcoma in the neck skeletal muscle of a Crlj:CD1 (ICR) mouse (36 weeks, dead). Necropsy revealed a solid white mass located in the neck skeletal muscle (scalenus muscle). Histological examination showed that the tumor consisted of atypical polygonal cells, a small osteoid clump, and bone tissue. Mitotic figures were observed. Serial sections showed that neoplastic cells lacked clear invasive proliferation to adjacent normal skeletal muscle and continuity with normal bone tissue. Immunohistochemical analysis showed that the neoplastic cells were positive for osteocalcin, osterix, vimentin, and S-100. Based on these results, the tumor was diagnosed as extraskeletal osteosarcoma in the neck skeletal muscle.</description><identifier>ISSN: 0914-9198</identifier><identifier>EISSN: 1881-915X</identifier><identifier>EISSN: 1347-7404</identifier><identifier>DOI: 10.1293/tox.2020-0083</identifier><identifier>PMID: 33976470</identifier><language>eng</language><publisher>TOKYO: JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY</publisher><subject>Biomedical materials ; Bone cancer ; Bones ; Case Report ; Cell proliferation ; extraskeletal osteosarcoma ; Life Sciences & Biomedicine ; mouse ; Muscles ; Musculoskeletal system ; Neck ; neck skeletal muscle ; Necropsy ; Osteocalcin ; Osteoid ; Osteosarcoma ; Pathology ; Sarcoma ; Science & Technology ; Skeletal muscle ; spontaneous tumor ; Tissue analysis ; Toxicology ; Tumors ; Vimentin</subject><ispartof>Journal of Toxicologic Pathology, 2021, Vol.34(2), pp.147-150</ispartof><rights>2021 The Japanese Society of Toxicologic Pathology</rights><rights>2021 The Japanese Society of Toxicologic Pathology.</rights><rights>Copyright Japan Science and Technology Agency 2021</rights><rights>2021 The Japanese Society of Toxicologic Pathology 2021</rights><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>0</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000683377000002</woscitedreferencesoriginalsourcerecordid><cites>FETCH-LOGICAL-c545t-f6cdfa4fd458b3fc2d7e58978dfdf7c0d93e3bd13a2be63fa12557abefc1627a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100254/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100254/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,1884,27929,27930,39263,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33976470$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ibi, Kanata</creatorcontrib><creatorcontrib>Chiba, Shiori</creatorcontrib><creatorcontrib>Koyama, Naomi</creatorcontrib><creatorcontrib>Hashimoto, Kazuto</creatorcontrib><creatorcontrib>Nejishima, Hiroaki</creatorcontrib><title>Spontaneous extraskeletal osteosarcoma in the neck skeletal muscle of a Crlj:CD1 (ICR) mouse</title><title>Journal of Toxicologic Pathology</title><addtitle>J TOXICOL PATHOL</addtitle><addtitle>J Toxicol Pathol</addtitle><description>Extraskeletal osteosarcoma is extremely rare in humans and animals, especially in rodents. This is the first case report on spontaneous extraskeletal osteosarcoma in the neck skeletal muscle of a Crlj:CD1 (ICR) mouse (36 weeks, dead). Necropsy revealed a solid white mass located in the neck skeletal muscle (scalenus muscle). Histological examination showed that the tumor consisted of atypical polygonal cells, a small osteoid clump, and bone tissue. Mitotic figures were observed. Serial sections showed that neoplastic cells lacked clear invasive proliferation to adjacent normal skeletal muscle and continuity with normal bone tissue. Immunohistochemical analysis showed that the neoplastic cells were positive for osteocalcin, osterix, vimentin, and S-100. Based on these results, the tumor was diagnosed as extraskeletal osteosarcoma in the neck skeletal muscle.</description><subject>Biomedical materials</subject><subject>Bone cancer</subject><subject>Bones</subject><subject>Case Report</subject><subject>Cell proliferation</subject><subject>extraskeletal osteosarcoma</subject><subject>Life Sciences & Biomedicine</subject><subject>mouse</subject><subject>Muscles</subject><subject>Musculoskeletal system</subject><subject>Neck</subject><subject>neck skeletal muscle</subject><subject>Necropsy</subject><subject>Osteocalcin</subject><subject>Osteoid</subject><subject>Osteosarcoma</subject><subject>Pathology</subject><subject>Sarcoma</subject><subject>Science & Technology</subject><subject>Skeletal muscle</subject><subject>spontaneous tumor</subject><subject>Tissue analysis</subject><subject>Toxicology</subject><subject>Tumors</subject><subject>Vimentin</subject><issn>0914-9198</issn><issn>1881-915X</issn><issn>1347-7404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><recordid>eNqNkcuL1TAUxoMoznV06VYCbhTpmEfTtC4Eqa-BAcEHuBBCmp7M7Z02uSapjv-96dyZqjuzSALnd758OR9CDyk5oazhz5O_PGGEkYKQmt9CG1rXtGio-HobbUhDy3xv6iN0L8YdIUwSwe-iI84bWZWSbNC3T3vvknbg54jhMgUdL2CEpEfsYwIfdTB-0nhwOG0BOzAXeCWmOZoRsLdY4zaMuxfta4qfnLYfn-Ip68F9dMfqMcKD6_MYfXn75nP7vjj78O60fXVWGFGKVNjK9FaXti9F3XFrWC9B1I2se9tbaUjfcOBdT7lmHVTcasqEkLoDa2jFpObH6OVBdz93E_QGXP7HqPZhmHT4pbwe1L8VN2zVuf-happnIsos8PhaIPjvM8Skdn4OLntWTDAilgEvVHGgTPAxBrDrC5SoJQyVw1ALq5YwMv_ob1srfTP9DDw7AD-h8zaaAZyBFSOEVFlFSrIslun6_-l2SDoN3rV-dim3tofWXUz6_E-TDmnICV755qViV9uN_7VqtjoocPw380LAFA</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Ibi, Kanata</creator><creator>Chiba, Shiori</creator><creator>Koyama, Naomi</creator><creator>Hashimoto, Kazuto</creator><creator>Nejishima, Hiroaki</creator><general>JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY</general><general>Japanese Soc Toxicologic Pathology</general><general>Japan Science and Technology Agency</general><general>Japanese Society of Toxicologic Pathology</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>20210101</creationdate><title>Spontaneous extraskeletal osteosarcoma in the neck skeletal muscle of a Crlj:CD1 (ICR) mouse</title><author>Ibi, Kanata ; Chiba, Shiori ; Koyama, Naomi ; Hashimoto, Kazuto ; Nejishima, Hiroaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c545t-f6cdfa4fd458b3fc2d7e58978dfdf7c0d93e3bd13a2be63fa12557abefc1627a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biomedical materials</topic><topic>Bone cancer</topic><topic>Bones</topic><topic>Case Report</topic><topic>Cell proliferation</topic><topic>extraskeletal osteosarcoma</topic><topic>Life Sciences & Biomedicine</topic><topic>mouse</topic><topic>Muscles</topic><topic>Musculoskeletal system</topic><topic>Neck</topic><topic>neck skeletal muscle</topic><topic>Necropsy</topic><topic>Osteocalcin</topic><topic>Osteoid</topic><topic>Osteosarcoma</topic><topic>Pathology</topic><topic>Sarcoma</topic><topic>Science & Technology</topic><topic>Skeletal muscle</topic><topic>spontaneous tumor</topic><topic>Tissue analysis</topic><topic>Toxicology</topic><topic>Tumors</topic><topic>Vimentin</topic><toplevel>online_resources</toplevel><creatorcontrib>Ibi, Kanata</creatorcontrib><creatorcontrib>Chiba, Shiori</creatorcontrib><creatorcontrib>Koyama, Naomi</creatorcontrib><creatorcontrib>Hashimoto, Kazuto</creatorcontrib><creatorcontrib>Nejishima, Hiroaki</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Toxicologic Pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ibi, Kanata</au><au>Chiba, Shiori</au><au>Koyama, Naomi</au><au>Hashimoto, Kazuto</au><au>Nejishima, Hiroaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneous extraskeletal osteosarcoma in the neck skeletal muscle of a Crlj:CD1 (ICR) mouse</atitle><jtitle>Journal of Toxicologic Pathology</jtitle><stitle>J TOXICOL PATHOL</stitle><addtitle>J Toxicol Pathol</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>34</volume><issue>2</issue><spage>147</spage><epage>150</epage><pages>147-150</pages><issn>0914-9198</issn><eissn>1881-915X</eissn><eissn>1347-7404</eissn><abstract>Extraskeletal osteosarcoma is extremely rare in humans and animals, especially in rodents. This is the first case report on spontaneous extraskeletal osteosarcoma in the neck skeletal muscle of a Crlj:CD1 (ICR) mouse (36 weeks, dead). Necropsy revealed a solid white mass located in the neck skeletal muscle (scalenus muscle). Histological examination showed that the tumor consisted of atypical polygonal cells, a small osteoid clump, and bone tissue. Mitotic figures were observed. Serial sections showed that neoplastic cells lacked clear invasive proliferation to adjacent normal skeletal muscle and continuity with normal bone tissue. Immunohistochemical analysis showed that the neoplastic cells were positive for osteocalcin, osterix, vimentin, and S-100. Based on these results, the tumor was diagnosed as extraskeletal osteosarcoma in the neck skeletal muscle.</abstract><cop>TOKYO</cop><pub>JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY</pub><pmid>33976470</pmid><doi>10.1293/tox.2020-0083</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biomedical materials Bone cancer Bones Case Report Cell proliferation extraskeletal osteosarcoma Life Sciences & Biomedicine mouse Muscles Musculoskeletal system Neck neck skeletal muscle Necropsy Osteocalcin Osteoid Osteosarcoma Pathology Sarcoma Science & Technology Skeletal muscle spontaneous tumor Tissue analysis Toxicology Tumors Vimentin |
| title | Spontaneous extraskeletal osteosarcoma in the neck skeletal muscle of a Crlj:CD1 (ICR) mouse |
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