Dietary Supplementation with Fructooligosaccharides Increase Survival Time in a Hamster Model of Clostridium difficile-Colitis
Fructooligosaccharides (FOS) are an indigestible, highly fermentable carbohydrate with a chain length of 3 to 5. They are known bifidogenic factors which may provide physiological benefits when fed. Two studies investigating the effect of FOS on survival in a hamster model of Clostridium difficile-c...
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| Veröffentlicht in: | Bioscience and Microflora 1997, Vol.16(2), pp.59-64 |
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| container_title | Bioscience and Microflora |
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| creator | WOLF, Bryan W. MEULBROEK, Jonathan A. JARVIS, Kenneth P. WHEELER, Keith B. GARLEB, Keith A. |
| description | Fructooligosaccharides (FOS) are an indigestible, highly fermentable carbohydrate with a chain length of 3 to 5. They are known bifidogenic factors which may provide physiological benefits when fed. Two studies investigating the effect of FOS on survival in a hamster model of Clostridium difficile-colitis were conducted. Female golden Syrian hamsters were treated with ciprofloxacin prior to C. difficile (strain VPI 10463) challenge. In experiment one, 41 hamsters were randomized among 1 of 6 treatments arranged in a 2×3 factorial (0 or 30 g FOS/L of drinking water; 0, 0.5×109 colony forming units, or 2.0×109 colony forming units C. difficile challenge). In experiment two, 63 hamsters were randomized among 1 of 8 treatments arranged in a 2×2×2 factorial (0 or 30 g FOS/L of drinking water; 0 or 2.0×109 colony forming units C. difficile challenge; 0 or 50 mg/kg body weight/day vancomycin treatment). In the first experiment, FOS increased (p |
| doi_str_mv | 10.12938/bifidus1996.16.59 |
| format | Article |
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They are known bifidogenic factors which may provide physiological benefits when fed. Two studies investigating the effect of FOS on survival in a hamster model of Clostridium difficile-colitis were conducted. Female golden Syrian hamsters were treated with ciprofloxacin prior to C. difficile (strain VPI 10463) challenge. In experiment one, 41 hamsters were randomized among 1 of 6 treatments arranged in a 2×3 factorial (0 or 30 g FOS/L of drinking water; 0, 0.5×109 colony forming units, or 2.0×109 colony forming units C. difficile challenge). In experiment two, 63 hamsters were randomized among 1 of 8 treatments arranged in a 2×2×2 factorial (0 or 30 g FOS/L of drinking water; 0 or 2.0×109 colony forming units C. difficile challenge; 0 or 50 mg/kg body weight/day vancomycin treatment). In the first experiment, FOS increased (p<0.01) median survival time (MST) of hamsters challenged with C. difficile. In the second experiment, the overall effect of FOS was to improve (p<0.05) MST. These data suggest that dietary supplementation with FOS increases median survival time in a hamster model of Clostridium difficile-colitis. Supplementation with fructooligosaccharides may be beneficial for patients at risk of C. difficile infection in long-term care institutions and hospital wards.</description><identifier>ISSN: 1342-1441</identifier><identifier>EISSN: 1349-8355</identifier><identifier>DOI: 10.12938/bifidus1996.16.59</identifier><language>eng</language><publisher>JAPAN BIFIDUS FOUNDATION</publisher><subject>Clostridium difficile ; colitis ; fructooligosaccharides ; hamster model</subject><ispartof>Bioscience and Microflora, 1997, Vol.16(2), pp.59-64</ispartof><rights>JAPAN BIFIDUS FOUNDATION</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2949-df76248b86adb2c525d80798f80669ebdbce235d0c67922dc19c9250e111b76c3</citedby><cites>FETCH-LOGICAL-c2949-df76248b86adb2c525d80798f80669ebdbce235d0c67922dc19c9250e111b76c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids></links><search><creatorcontrib>WOLF, Bryan W.</creatorcontrib><creatorcontrib>MEULBROEK, Jonathan A.</creatorcontrib><creatorcontrib>JARVIS, Kenneth P.</creatorcontrib><creatorcontrib>WHEELER, Keith B.</creatorcontrib><creatorcontrib>GARLEB, Keith A.</creatorcontrib><title>Dietary Supplementation with Fructooligosaccharides Increase Survival Time in a Hamster Model of Clostridium difficile-Colitis</title><title>Bioscience and Microflora</title><addtitle>Bioscience Microflora</addtitle><description>Fructooligosaccharides (FOS) are an indigestible, highly fermentable carbohydrate with a chain length of 3 to 5. They are known bifidogenic factors which may provide physiological benefits when fed. Two studies investigating the effect of FOS on survival in a hamster model of Clostridium difficile-colitis were conducted. Female golden Syrian hamsters were treated with ciprofloxacin prior to C. difficile (strain VPI 10463) challenge. In experiment one, 41 hamsters were randomized among 1 of 6 treatments arranged in a 2×3 factorial (0 or 30 g FOS/L of drinking water; 0, 0.5×109 colony forming units, or 2.0×109 colony forming units C. difficile challenge). In experiment two, 63 hamsters were randomized among 1 of 8 treatments arranged in a 2×2×2 factorial (0 or 30 g FOS/L of drinking water; 0 or 2.0×109 colony forming units C. difficile challenge; 0 or 50 mg/kg body weight/day vancomycin treatment). In the first experiment, FOS increased (p<0.01) median survival time (MST) of hamsters challenged with C. difficile. In the second experiment, the overall effect of FOS was to improve (p<0.05) MST. These data suggest that dietary supplementation with FOS increases median survival time in a hamster model of Clostridium difficile-colitis. Supplementation with fructooligosaccharides may be beneficial for patients at risk of C. difficile infection in long-term care institutions and hospital wards.</description><subject>Clostridium difficile</subject><subject>colitis</subject><subject>fructooligosaccharides</subject><subject>hamster model</subject><issn>1342-1441</issn><issn>1349-8355</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNpdkMtOwzAQRS0EEqXwA6z8AymxEzvxEgVKKxWxoKwjx560U-VR2U4RG76d0CKE2MzMYs6V7iHklsUzxlWS31VYox08U0rOmJwJdUYmLElVlCdCnB9vHrE0ZZfkyvtdHCcyZ2pCPh8QgnYf9HXY7xtooQs6YN_RdwxbOneDCX3f4Kb32pitdmjB02VnHGgPI-QOeNANXWMLFDuq6UK3PoCjz72FhvY1LZreh5HDoaUW6xoNNhAVY2hAf00uat14uPnZU_I2f1wXi2j18rQs7leR4WosYetM8jSvcqltxY3gwuZxpvI6j6VUUNnKAE-EjY3MFOfWMGUUFzEwxqpMmmRK-CnXuN57B3W5d9iOvUsWl0eD5R-DJZOlUCM0P0E7H_QGfhHtApoG_hP8NIT6ffgWVkKXfAHvBYKt</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>WOLF, Bryan W.</creator><creator>MEULBROEK, Jonathan A.</creator><creator>JARVIS, Kenneth P.</creator><creator>WHEELER, Keith B.</creator><creator>GARLEB, Keith A.</creator><general>JAPAN BIFIDUS FOUNDATION</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1997</creationdate><title>Dietary Supplementation with Fructooligosaccharides Increase Survival Time in a Hamster Model of Clostridium difficile-Colitis</title><author>WOLF, Bryan W. ; MEULBROEK, Jonathan A. ; JARVIS, Kenneth P. ; WHEELER, Keith B. ; GARLEB, Keith A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2949-df76248b86adb2c525d80798f80669ebdbce235d0c67922dc19c9250e111b76c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Clostridium difficile</topic><topic>colitis</topic><topic>fructooligosaccharides</topic><topic>hamster model</topic><toplevel>online_resources</toplevel><creatorcontrib>WOLF, Bryan W.</creatorcontrib><creatorcontrib>MEULBROEK, Jonathan A.</creatorcontrib><creatorcontrib>JARVIS, Kenneth P.</creatorcontrib><creatorcontrib>WHEELER, Keith B.</creatorcontrib><creatorcontrib>GARLEB, Keith A.</creatorcontrib><collection>CrossRef</collection><jtitle>Bioscience and Microflora</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WOLF, Bryan W.</au><au>MEULBROEK, Jonathan A.</au><au>JARVIS, Kenneth P.</au><au>WHEELER, Keith B.</au><au>GARLEB, Keith A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary Supplementation with Fructooligosaccharides Increase Survival Time in a Hamster Model of Clostridium difficile-Colitis</atitle><jtitle>Bioscience and Microflora</jtitle><addtitle>Bioscience Microflora</addtitle><date>1997</date><risdate>1997</risdate><volume>16</volume><issue>2</issue><spage>59</spage><epage>64</epage><pages>59-64</pages><issn>1342-1441</issn><eissn>1349-8355</eissn><abstract>Fructooligosaccharides (FOS) are an indigestible, highly fermentable carbohydrate with a chain length of 3 to 5. They are known bifidogenic factors which may provide physiological benefits when fed. Two studies investigating the effect of FOS on survival in a hamster model of Clostridium difficile-colitis were conducted. Female golden Syrian hamsters were treated with ciprofloxacin prior to C. difficile (strain VPI 10463) challenge. In experiment one, 41 hamsters were randomized among 1 of 6 treatments arranged in a 2×3 factorial (0 or 30 g FOS/L of drinking water; 0, 0.5×109 colony forming units, or 2.0×109 colony forming units C. difficile challenge). In experiment two, 63 hamsters were randomized among 1 of 8 treatments arranged in a 2×2×2 factorial (0 or 30 g FOS/L of drinking water; 0 or 2.0×109 colony forming units C. difficile challenge; 0 or 50 mg/kg body weight/day vancomycin treatment). In the first experiment, FOS increased (p<0.01) median survival time (MST) of hamsters challenged with C. difficile. In the second experiment, the overall effect of FOS was to improve (p<0.05) MST. These data suggest that dietary supplementation with FOS increases median survival time in a hamster model of Clostridium difficile-colitis. Supplementation with fructooligosaccharides may be beneficial for patients at risk of C. difficile infection in long-term care institutions and hospital wards.</abstract><pub>JAPAN BIFIDUS FOUNDATION</pub><doi>10.12938/bifidus1996.16.59</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Bioscience and Microflora, 1997, Vol.16(2), pp.59-64 |
| issn | 1342-1441 1349-8355 |
| language | eng |
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| source | J-STAGE Free |
| subjects | Clostridium difficile colitis fructooligosaccharides hamster model |
| title | Dietary Supplementation with Fructooligosaccharides Increase Survival Time in a Hamster Model of Clostridium difficile-Colitis |
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