Regulation of Glucose Transporter (GLUT1) Gene Expression by Angiotensin II in Mesangial Cells: Involvement of HB-EGF and EGF Receptor Transactivation

In the development of diabetic nephropathy, angiotensin (Ang) II is thought to exert numerous actions on the glomerulus, and especially on the mesangium. However, the role(s) played by Ang II in the glucose metabolism per se in mesangial cells remains unclear. Ang II, at least via its type 1 recepto...

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Veröffentlicht in:	Hypertension Research 2003, Vol.26(1), pp.67-73
Hauptverfasser:	NOSE, Atsuko, MORI, Yasukiyo, UCHIYAMA-TANAKA, Yoko, KISHIMOTO, Noriko, MARUYAMA, Katsuya, MATSUBARA, Hiroaki, IWASAKA, Toshiji
Format:	Artikel
Sprache:	eng
Schlagworte:	angiotensin II Angiotensin II - pharmacology Animals Calcium - metabolism Carcinogens - pharmacology Cells, Cultured epidermal growth factor Epidermal Growth Factor - metabolism Glomerular Mesangium - cytology Glomerular Mesangium - metabolism glucose transporter Glucose Transporter Type 1 Heparin-binding EGF-like Growth Factor heparin-binding epidermal growth factor-like growth factor Intercellular Signaling Peptides and Proteins Male MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology mesangial cell Mice Mice, Inbred C57BL Monosaccharide Transport Proteins - genetics Phorbol Esters - pharmacology Protein Kinase C - metabolism Receptor, Epidermal Growth Factor - metabolism RNA, Messenger - metabolism Up-Regulation Vasoconstrictor Agents - pharmacology
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