Malignant germ cell tumors of the head and neck in childhood
From 1962 through 1987, four children were diagnosed at our institution with primary germ cell malignancies of the extracranial head and neck regions. Ages of the children ranged from 2 to 44 months. Histologic findings included 2 yolk sac carcinoma (endodermal sinus tumor), 1 malignant teratoma wit...
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| Veröffentlicht in: | The Laryngoscope 1989-07, Vol.99 (7), p.732-735 |
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| container_title | The Laryngoscope |
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| creator | Stephenson, Jeffrey A. Mayland, Diane M. Kun, Larry E. Etcubanas, Erlinda Thompson, Elizabeth I. Gross, Charles W. |
| description | From 1962 through 1987, four children were diagnosed at our institution with primary germ cell malignancies of the extracranial head and neck regions. Ages of the children ranged from 2 to 44 months. Histologic findings included 2 yolk sac carcinoma (endodermal sinus tumor), 1 malignant teratoma with nephroblastoma (Wilm's tumor), and 1 malignant teratoma with neuroblastoma (primitive neuroectodermal) components. Complete clinical and surgical staging was performed to rule out additional sites of disease. All patients initially underwent either biopsy or, when technically feasible, resection. Three patients received combination chemotherapy and two received irradiation. Three patients died of progressive disease. One patient who had yolk sac carcinoma of the temporomandibular region is alive and free of disease 40 months after therapy. Complete surgical resection is indicated for teratomatous tumors, if technically feasible. The malignant components of these tumors are sensitive to both chemotherapy and irradiation and combined therapy may be beneficial. |
| doi_str_mv | 10.1288/00005537-198907000-00013 |
| format | Article |
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Ages of the children ranged from 2 to 44 months. Histologic findings included 2 yolk sac carcinoma (endodermal sinus tumor), 1 malignant teratoma with nephroblastoma (Wilm's tumor), and 1 malignant teratoma with neuroblastoma (primitive neuroectodermal) components. Complete clinical and surgical staging was performed to rule out additional sites of disease. All patients initially underwent either biopsy or, when technically feasible, resection. Three patients received combination chemotherapy and two received irradiation. Three patients died of progressive disease. One patient who had yolk sac carcinoma of the temporomandibular region is alive and free of disease 40 months after therapy. Complete surgical resection is indicated for teratomatous tumors, if technically feasible. The malignant components of these tumors are sensitive to both chemotherapy and irradiation and combined therapy may be beneficial.</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1288/00005537-198907000-00013</identifier><identifier>PMID: 2545983</identifier><identifier>CODEN: LARYA8</identifier><language>eng</language><publisher>Hoboken, NJ: John Wiley & Sons, Inc</publisher><subject>Biological and medical sciences ; Cervical Vertebrae ; Child, Preschool ; Dysgerminoma - pathology ; Female ; Head and Neck Neoplasms - pathology ; Humans ; Infant ; Male ; Maxillary Sinus Neoplasms - pathology ; Medical sciences ; Neoplasms, Germ Cell and Embryonal - pathology ; Neoplasms, Multiple Primary - pathology ; Neuroblastoma - pathology ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology ; Spinal Neoplasms - pathology ; Temporomandibular Joint Disorders - pathology ; Teratoma - pathology ; Tumors ; Wilms Tumor - pathology</subject><ispartof>The Laryngoscope, 1989-07, Vol.99 (7), p.732-735</ispartof><rights>Copyright © 1989 The Triological Society</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5173-25000ca5e810645606f52644925e6b7ec5159ea3070a4e3c83013671bb50944e3</citedby><cites>FETCH-LOGICAL-c5173-25000ca5e810645606f52644925e6b7ec5159ea3070a4e3c83013671bb50944e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7357364$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2545983$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stephenson, Jeffrey A.</creatorcontrib><creatorcontrib>Mayland, Diane M.</creatorcontrib><creatorcontrib>Kun, Larry E.</creatorcontrib><creatorcontrib>Etcubanas, Erlinda</creatorcontrib><creatorcontrib>Thompson, Elizabeth I.</creatorcontrib><creatorcontrib>Gross, Charles W.</creatorcontrib><title>Malignant germ cell tumors of the head and neck in childhood</title><title>The Laryngoscope</title><addtitle>The Laryngoscope</addtitle><description>From 1962 through 1987, four children were diagnosed at our institution with primary germ cell malignancies of the extracranial head and neck regions. Ages of the children ranged from 2 to 44 months. Histologic findings included 2 yolk sac carcinoma (endodermal sinus tumor), 1 malignant teratoma with nephroblastoma (Wilm's tumor), and 1 malignant teratoma with neuroblastoma (primitive neuroectodermal) components. Complete clinical and surgical staging was performed to rule out additional sites of disease. All patients initially underwent either biopsy or, when technically feasible, resection. Three patients received combination chemotherapy and two received irradiation. Three patients died of progressive disease. One patient who had yolk sac carcinoma of the temporomandibular region is alive and free of disease 40 months after therapy. Complete surgical resection is indicated for teratomatous tumors, if technically feasible. The malignant components of these tumors are sensitive to both chemotherapy and irradiation and combined therapy may be beneficial.</description><subject>Biological and medical sciences</subject><subject>Cervical Vertebrae</subject><subject>Child, Preschool</subject><subject>Dysgerminoma - pathology</subject><subject>Female</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Maxillary Sinus Neoplasms - pathology</subject><subject>Medical sciences</subject><subject>Neoplasms, Germ Cell and Embryonal - pathology</subject><subject>Neoplasms, Multiple Primary - pathology</subject><subject>Neuroblastoma - pathology</subject><subject>Otorhinolaryngology (head neck, general aspects and miscellaneous)</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Spinal Neoplasms - pathology</subject><subject>Temporomandibular Joint Disorders - pathology</subject><subject>Teratoma - pathology</subject><subject>Tumors</subject><subject>Wilms Tumor - pathology</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1LwzAUhoMoc05_gpALb6tJk9M24M2YuglzwpxMr0Kapmu1H6Pp0P174zp3bSCEnPO-5-NBCFNyTf0ouiHuALDQoyISJHQ_z13KjlCfAqMeFwKOUZ8Qn3kR-G-n6MzaD6cIGZAe6vnAQUSsj26fVJGvKlW1eGWaEmtTFLjdlHVjcZ3iNjM4MyrBqkpwZfQnziuss7xIsrpOztFJqgprLvbvAL0-3C9GE2_6PH4cDaeeBtfQ88HNphWYiJKAQ0CCFPyAc-GDCeLQOBUIo5jbQ3HDdMTcJkFI4xiI4C4yQFFXVze1tY1J5brJS9VsJSXyl4f84yEPPOSOh7Nedtb1Ji5NcjDuAbj81T6vrFZF2qhK5_Ygc7hCFnAnu-tkX3lhtv9uL6fD-TsAJ8JFd9N4XZnctub7UEY1nzIIWQhyORvLxQubzyajpVyyH6ibhuI</recordid><startdate>198907</startdate><enddate>198907</enddate><creator>Stephenson, Jeffrey A.</creator><creator>Mayland, Diane M.</creator><creator>Kun, Larry E.</creator><creator>Etcubanas, Erlinda</creator><creator>Thompson, Elizabeth I.</creator><creator>Gross, Charles W.</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198907</creationdate><title>Malignant germ cell tumors of the head and neck in childhood</title><author>Stephenson, Jeffrey A. ; Mayland, Diane M. ; Kun, Larry E. ; Etcubanas, Erlinda ; Thompson, Elizabeth I. ; Gross, Charles W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5173-25000ca5e810645606f52644925e6b7ec5159ea3070a4e3c83013671bb50944e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Biological and medical sciences</topic><topic>Cervical Vertebrae</topic><topic>Child, Preschool</topic><topic>Dysgerminoma - pathology</topic><topic>Female</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Maxillary Sinus Neoplasms - pathology</topic><topic>Medical sciences</topic><topic>Neoplasms, Germ Cell and Embryonal - pathology</topic><topic>Neoplasms, Multiple Primary - pathology</topic><topic>Neuroblastoma - pathology</topic><topic>Otorhinolaryngology (head neck, general aspects and miscellaneous)</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Spinal Neoplasms - pathology</topic><topic>Temporomandibular Joint Disorders - pathology</topic><topic>Teratoma - pathology</topic><topic>Tumors</topic><topic>Wilms Tumor - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stephenson, Jeffrey A.</creatorcontrib><creatorcontrib>Mayland, Diane M.</creatorcontrib><creatorcontrib>Kun, Larry E.</creatorcontrib><creatorcontrib>Etcubanas, Erlinda</creatorcontrib><creatorcontrib>Thompson, Elizabeth I.</creatorcontrib><creatorcontrib>Gross, Charles W.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stephenson, Jeffrey A.</au><au>Mayland, Diane M.</au><au>Kun, Larry E.</au><au>Etcubanas, Erlinda</au><au>Thompson, Elizabeth I.</au><au>Gross, Charles W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Malignant germ cell tumors of the head and neck in childhood</atitle><jtitle>The Laryngoscope</jtitle><addtitle>The Laryngoscope</addtitle><date>1989-07</date><risdate>1989</risdate><volume>99</volume><issue>7</issue><spage>732</spage><epage>735</epage><pages>732-735</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><coden>LARYA8</coden><abstract>From 1962 through 1987, four children were diagnosed at our institution with primary germ cell malignancies of the extracranial head and neck regions. Ages of the children ranged from 2 to 44 months. Histologic findings included 2 yolk sac carcinoma (endodermal sinus tumor), 1 malignant teratoma with nephroblastoma (Wilm's tumor), and 1 malignant teratoma with neuroblastoma (primitive neuroectodermal) components. Complete clinical and surgical staging was performed to rule out additional sites of disease. All patients initially underwent either biopsy or, when technically feasible, resection. Three patients received combination chemotherapy and two received irradiation. Three patients died of progressive disease. One patient who had yolk sac carcinoma of the temporomandibular region is alive and free of disease 40 months after therapy. Complete surgical resection is indicated for teratomatous tumors, if technically feasible. The malignant components of these tumors are sensitive to both chemotherapy and irradiation and combined therapy may be beneficial.</abstract><cop>Hoboken, NJ</cop><pub>John Wiley & Sons, Inc</pub><pmid>2545983</pmid><doi>10.1288/00005537-198907000-00013</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0023-852X |
| ispartof | The Laryngoscope, 1989-07, Vol.99 (7), p.732-735 |
| issn | 0023-852X 1531-4995 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Biological and medical sciences Cervical Vertebrae Child, Preschool Dysgerminoma - pathology Female Head and Neck Neoplasms - pathology Humans Infant Male Maxillary Sinus Neoplasms - pathology Medical sciences Neoplasms, Germ Cell and Embryonal - pathology Neoplasms, Multiple Primary - pathology Neuroblastoma - pathology Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Spinal Neoplasms - pathology Temporomandibular Joint Disorders - pathology Teratoma - pathology Tumors Wilms Tumor - pathology |
| title | Malignant germ cell tumors of the head and neck in childhood |
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