Comparison of Immunohistochemical Expression of DNMT3B among Oral, Laryngeal and Skin SCC
Background: Recently epigenetic alterations have received increased attention because of theirimportant role in the process of tumerigenesis. It has been found that more than half of genetic changes were epigenetic. Epigenetic alterations are catalyzed by DNMTs enzymes. Increased knowledge about thi...
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| Veröffentlicht in: | Journal of the college of dentistry 2016-12, Vol.28 (4), p.61-67 |
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| creator | Younis , Wasan H Abed , Khaled J |
| description | Background: Recently epigenetic alterations have received increased attention because of theirimportant role in the process of tumerigenesis. It has been found that more than half of genetic changes were epigenetic. Epigenetic alterations are catalyzed by DNMTs enzymes. Increased knowledge about this molecular event may achieve progress in the war against cancer. The aim of this study was to evaluate and compare the expression of DNMT3B among oral, laryngeal and skin SCC. Materials and Methods: This study was performed on (120) formalin-fixed, paraffin-embedded blocks, histopathologically diagnosed as oral, laryngeal and skin SCC). Immunohistochemical staining of DNMT3B antibody was performed on each case of this study. Results: The immunohistochemical analysis showed that the DNMT3b is over expressed in oral, laryngeal and skin squamous cell carcinoma as (77.5%), (77.5%) and (72.5%) respectively, withsignificant difference in expression among them (P=0.009), The expression in all the three types is correlated positively with the degree of differentiation (P |
| doi_str_mv | 10.12816/0033212 |
| format | Article |
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It has been found that more than half of genetic changes were epigenetic. Epigenetic alterations are catalyzed by DNMTs enzymes. Increased knowledge about this molecular event may achieve progress in the war against cancer. The aim of this study was to evaluate and compare the expression of DNMT3B among oral, laryngeal and skin SCC. Materials and Methods: This study was performed on (120) formalin-fixed, paraffin-embedded blocks, histopathologically diagnosed as oral, laryngeal and skin SCC). Immunohistochemical staining of DNMT3B antibody was performed on each case of this study. Results: The immunohistochemical analysis showed that the DNMT3b is over expressed in oral, laryngeal and skin squamous cell carcinoma as (77.5%), (77.5%) and (72.5%) respectively, withsignificant difference in expression among them (P=0.009), The expression in all the three types is correlated positively with the degree of differentiation (P</description><identifier>ISSN: 1680-0087</identifier><identifier>EISSN: 2311-5270</identifier><identifier>DOI: 10.12816/0033212</identifier><language>eng</language><publisher>Baghdad - Iraq: College of Dentistry : Baghdad University</publisher><subject>IMMUNITY ; IMMUNOHISTOCHEMISTRY ; LARYNX ; ORAL HEALTH ; OTOLARYNGOLOGY ; SKIN ; الجلد ; الحنجرة ; الكيمياء النسجية المناعية ; المناعة ; صحة الفم ; طب الأنف و الأذن و الحنجرة</subject><ispartof>Journal of the college of dentistry, 2016-12, Vol.28 (4), p.61-67</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttps://static.almanhal.com/covers/titl/96445/cover-lg.jpg</thumbnail><link.rule.ids>314,780,784,864,2102,27924,27925</link.rule.ids></links><search><creatorcontrib>Younis , Wasan H</creatorcontrib><creatorcontrib>Abed , Khaled J</creatorcontrib><title>Comparison of Immunohistochemical Expression of DNMT3B among Oral, Laryngeal and Skin SCC</title><title>Journal of the college of dentistry</title><description>Background: Recently epigenetic alterations have received increased attention because of theirimportant role in the process of tumerigenesis. 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Results: The immunohistochemical analysis showed that the DNMT3b is over expressed in oral, laryngeal and skin squamous cell carcinoma as (77.5%), (77.5%) and (72.5%) respectively, withsignificant difference in expression among them (P=0.009), The expression in all the three types is correlated positively with the degree of differentiation (P</description><subject>IMMUNITY</subject><subject>IMMUNOHISTOCHEMISTRY</subject><subject>LARYNX</subject><subject>ORAL HEALTH</subject><subject>OTOLARYNGOLOGY</subject><subject>SKIN</subject><subject>الجلد</subject><subject>الحنجرة</subject><subject>الكيمياء النسجية المناعية</subject><subject>المناعة</subject><subject>صحة الفم</subject><subject>طب الأنف و الأذن و الحنجرة</subject><issn>1680-0087</issn><issn>2311-5270</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNo9kE1Lw0AURQdRsNSCf0DI0oXRNzPJZLLUWLVQ7aJ14Sq8zEebmmTKTAX994amdHXhcd7hcgm5pnBPmaTiAYBzRtkZGTFOaZyyDM7JiAoJMYDMLskkhC0A0IxDRtmIfBWu3aGvg-siZ6NZ2_50blOHvVMb09YKm2j6u_MmhHognj_eV_wpwtZ162jhsbmL5uj_urXpUex0tPyuu2hZFFfkwmITzOSYY_L5Ml0Vb_F88TorHucx0jRlcZ6CEZYLrSsFFKVUItNUAa8ybZXGrEqpqJTRQCsrc5nYKqmSRKDWgkmJfExmg1c73JY7X7d9ndJhXR4Ozq9L9PtaNaYUef-jWKZzmiZCJcjAWm2UBskqqVjvuh1cyrsQvLEnH4XysHB5XLhHbwYUmxa7DTYnNBdJkvJ_7_F2gg</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Younis , Wasan H</creator><creator>Abed , Khaled J</creator><general>College of Dentistry : Baghdad University</general><general>College of Dentistry/ University of Baghdad</general><scope>~6Z</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>DOA</scope></search><sort><creationdate>20161201</creationdate><title>Comparison of Immunohistochemical Expression of DNMT3B among Oral, Laryngeal and Skin SCC</title><author>Younis , Wasan H ; Abed , Khaled J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a1552-950e6f36ddbc01a88c67d1c03b7dfcda7b516bced01bf8984fb4b446add6288a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>IMMUNITY</topic><topic>IMMUNOHISTOCHEMISTRY</topic><topic>LARYNX</topic><topic>ORAL HEALTH</topic><topic>OTOLARYNGOLOGY</topic><topic>SKIN</topic><topic>الجلد</topic><topic>الحنجرة</topic><topic>الكيمياء النسجية المناعية</topic><topic>المناعة</topic><topic>صحة الفم</topic><topic>طب الأنف و الأذن و الحنجرة</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Younis , Wasan H</creatorcontrib><creatorcontrib>Abed , Khaled J</creatorcontrib><collection>Al Manhal All Journals Collection</collection><collection>CrossRef</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of the college of dentistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Younis , Wasan H</au><au>Abed , Khaled J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Immunohistochemical Expression of DNMT3B among Oral, Laryngeal and Skin SCC</atitle><jtitle>Journal of the college of dentistry</jtitle><date>2016-12-01</date><risdate>2016</risdate><volume>28</volume><issue>4</issue><spage>61</spage><epage>67</epage><pages>61-67</pages><issn>1680-0087</issn><eissn>2311-5270</eissn><abstract>Background: Recently epigenetic alterations have received increased attention because of theirimportant role in the process of tumerigenesis. It has been found that more than half of genetic changes were epigenetic. Epigenetic alterations are catalyzed by DNMTs enzymes. Increased knowledge about this molecular event may achieve progress in the war against cancer. The aim of this study was to evaluate and compare the expression of DNMT3B among oral, laryngeal and skin SCC. Materials and Methods: This study was performed on (120) formalin-fixed, paraffin-embedded blocks, histopathologically diagnosed as oral, laryngeal and skin SCC). Immunohistochemical staining of DNMT3B antibody was performed on each case of this study. 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| subjects | IMMUNITY IMMUNOHISTOCHEMISTRY LARYNX ORAL HEALTH OTOLARYNGOLOGY SKIN الجلد الحنجرة الكيمياء النسجية المناعية المناعة صحة الفم طب الأنف و الأذن و الحنجرة |
| title | Comparison of Immunohistochemical Expression of DNMT3B among Oral, Laryngeal and Skin SCC |
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