Hypotensive effect of fish protein hydrolysate
Fish protein hydrolysate (FPH) prepared from defatted sardine meal by treatment with alkaline protease was tested for inhibitory activity against angiotensin I converting enzyme (ACE) and for hypotensive effects on spontaneously hypertensive rats (SHR). FPH at 0.18mg protein/ml concentration provide...
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| Veröffentlicht in: | Nippon Nōgeikagaku Kaishi 1991/01/15, Vol.65(1), pp.35-43 |
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| container_title | Nippon Nōgeikagaku Kaishi |
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| creator | Sugiyama, K. (Lion Corp., Odawara, Kanagawa (Japan). Biological Science Labs.) Takada, K Egawa, M Yamamoto, I Onzuka, H Oba, K |
| description | Fish protein hydrolysate (FPH) prepared from defatted sardine meal by treatment with alkaline protease was tested for inhibitory activity against angiotensin I converting enzyme (ACE) and for hypotensive effects on spontaneously hypertensive rats (SHR). FPH at 0.18mg protein/ml concentration provided 50% inhibition against ACE, and FPH was more effective compared with five hydrolysates prepared from defatted sardine meal by treatment with other proteases. Inhibitory activity was found in many fractions in gel chromatography of FPH, showing that FPH contained many kinds of active peptides. About 60% of the inhibitory activity of FPH was retained even after an in vitro digestivility test. When FPH was orally administered at a dosage of 2.0g protein/kg to SHR, blood pressure was reduced and the reduction continued for 6 hr after administration. Diet containing FPH as the sole protein source had a stronger hypotensive effect and a higher survival ratio in stroke-prone SHR (SHR-SP) than commercial diet. Furthermore, rats were examined histologically, but the incidence of abnormality in organs was not different from rats fed FPH and commercial diets. |
| doi_str_mv | 10.1271/nogeikagaku1924.65.35 |
| format | Article |
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(Lion Corp., Odawara, Kanagawa (Japan). Biological Science Labs.) ; Takada, K ; Egawa, M ; Yamamoto, I ; Onzuka, H ; Oba, K</creator><creatorcontrib>Sugiyama, K. (Lion Corp., Odawara, Kanagawa (Japan). Biological Science Labs.) ; Takada, K ; Egawa, M ; Yamamoto, I ; Onzuka, H ; Oba, K</creatorcontrib><description>Fish protein hydrolysate (FPH) prepared from defatted sardine meal by treatment with alkaline protease was tested for inhibitory activity against angiotensin I converting enzyme (ACE) and for hypotensive effects on spontaneously hypertensive rats (SHR). FPH at 0.18mg protein/ml concentration provided 50% inhibition against ACE, and FPH was more effective compared with five hydrolysates prepared from defatted sardine meal by treatment with other proteases. Inhibitory activity was found in many fractions in gel chromatography of FPH, showing that FPH contained many kinds of active peptides. About 60% of the inhibitory activity of FPH was retained even after an in vitro digestivility test. When FPH was orally administered at a dosage of 2.0g protein/kg to SHR, blood pressure was reduced and the reduction continued for 6 hr after administration. Diet containing FPH as the sole protein source had a stronger hypotensive effect and a higher survival ratio in stroke-prone SHR (SHR-SP) than commercial diet. Furthermore, rats were examined histologically, but the incidence of abnormality in organs was not different from rats fed FPH and commercial diets.</description><identifier>ISSN: 0002-1407</identifier><identifier>EISSN: 1883-6844</identifier><identifier>DOI: 10.1271/nogeikagaku1924.65.35</identifier><language>jpn</language><publisher>Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>BLOOD PRESSURE ; CONCENTRADO DE PROTEINAS DE PESCADO ; CONCENTRE PROTEIQUE DE POISSON ; FISH PRODUCTS ; FISH PROTEIN CONCENTRATES ; PRESION SANGUINEA ; PRESSION SANGUINE ; PRODUCTOS DERIVADOS DEL PESCADO ; PRODUIT A BASE DE POISSON</subject><ispartof>Nippon Nōgeikagaku Kaishi, 1991/01/15, Vol.65(1), pp.35-43</ispartof><rights>JAPAN SOCIETY FOR BIOSCIENCE,BIOTECHNOLOGY, ANDAGROCHEMISTRY</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-a65b062f26248d9acf682ede40833066c6376f4b74bddf808375b2a4191e16383</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1877,27905,27906</link.rule.ids></links><search><creatorcontrib>Sugiyama, K. 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Inhibitory activity was found in many fractions in gel chromatography of FPH, showing that FPH contained many kinds of active peptides. About 60% of the inhibitory activity of FPH was retained even after an in vitro digestivility test. When FPH was orally administered at a dosage of 2.0g protein/kg to SHR, blood pressure was reduced and the reduction continued for 6 hr after administration. Diet containing FPH as the sole protein source had a stronger hypotensive effect and a higher survival ratio in stroke-prone SHR (SHR-SP) than commercial diet. Furthermore, rats were examined histologically, but the incidence of abnormality in organs was not different from rats fed FPH and commercial diets.</description><subject>BLOOD PRESSURE</subject><subject>CONCENTRADO DE PROTEINAS DE PESCADO</subject><subject>CONCENTRE PROTEIQUE DE POISSON</subject><subject>FISH PRODUCTS</subject><subject>FISH PROTEIN CONCENTRATES</subject><subject>PRESION SANGUINEA</subject><subject>PRESSION SANGUINE</subject><subject>PRODUCTOS DERIVADOS DEL PESCADO</subject><subject>PRODUIT A BASE DE POISSON</subject><issn>0002-1407</issn><issn>1883-6844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><recordid>eNptj9tKw0AQhhdRsNS-gCDkBRL3ONlcSlHbUtALvV42yWy6bU3KbhTy9kYivRBvZpjD98FPyB2jGeM5u2-7Bv3BNvbwyQouM1CZUBdkxrQWKWgpL8mMUspTJml-TRYx7seRqrwALmYkWw2nrsc2-i9M0Dms-qRzifNxl5zCePFtshvq0B2HaHu8IVfOHiMufvucvD89vi1X6fbleb182KaV4NCnFlRJgTsOXOq6sJUDzbFGSbUQFKACkYOTZS7LunZ63Oaq5FaygiEDocWcqMlbhS7GgM6cgv-wYTCMmp_c5k9uA8oINXKbidvH3jZ4pmzofXXE_yg2FaHOT9XOBoPtKLudZM52xjbBR7N5LRjlBWfiGxszcTI</recordid><startdate>19910101</startdate><enddate>19910101</enddate><creator>Sugiyama, K. 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Biological Science Labs.)</creatorcontrib><creatorcontrib>Takada, K</creatorcontrib><creatorcontrib>Egawa, M</creatorcontrib><creatorcontrib>Yamamoto, I</creatorcontrib><creatorcontrib>Onzuka, H</creatorcontrib><creatorcontrib>Oba, K</creatorcontrib><collection>AGRIS</collection><collection>CrossRef</collection><jtitle>Nippon Nōgeikagaku Kaishi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sugiyama, K. (Lion Corp., Odawara, Kanagawa (Japan). Biological Science Labs.)</au><au>Takada, K</au><au>Egawa, M</au><au>Yamamoto, I</au><au>Onzuka, H</au><au>Oba, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypotensive effect of fish protein hydrolysate</atitle><jtitle>Nippon Nōgeikagaku Kaishi</jtitle><addtitle>Nippon Nōgeikagaku Kaishi</addtitle><date>1991-01-01</date><risdate>1991</risdate><volume>65</volume><issue>1</issue><spage>35</spage><epage>43</epage><pages>35-43</pages><issn>0002-1407</issn><eissn>1883-6844</eissn><abstract>Fish protein hydrolysate (FPH) prepared from defatted sardine meal by treatment with alkaline protease was tested for inhibitory activity against angiotensin I converting enzyme (ACE) and for hypotensive effects on spontaneously hypertensive rats (SHR). FPH at 0.18mg protein/ml concentration provided 50% inhibition against ACE, and FPH was more effective compared with five hydrolysates prepared from defatted sardine meal by treatment with other proteases. Inhibitory activity was found in many fractions in gel chromatography of FPH, showing that FPH contained many kinds of active peptides. About 60% of the inhibitory activity of FPH was retained even after an in vitro digestivility test. When FPH was orally administered at a dosage of 2.0g protein/kg to SHR, blood pressure was reduced and the reduction continued for 6 hr after administration. Diet containing FPH as the sole protein source had a stronger hypotensive effect and a higher survival ratio in stroke-prone SHR (SHR-SP) than commercial diet. Furthermore, rats were examined histologically, but the incidence of abnormality in organs was not different from rats fed FPH and commercial diets.</abstract><pub>Japan Society for Bioscience, Biotechnology, and Agrochemistry</pub><doi>10.1271/nogeikagaku1924.65.35</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0002-1407 |
| ispartof | Nippon Nōgeikagaku Kaishi, 1991/01/15, Vol.65(1), pp.35-43 |
| issn | 0002-1407 1883-6844 |
| language | jpn |
| recordid | cdi_crossref_primary_10_1271_nogeikagaku1924_65_35 |
| source | J-STAGE Free; EZB-FREE-00999 freely available EZB journals |
| subjects | BLOOD PRESSURE CONCENTRADO DE PROTEINAS DE PESCADO CONCENTRE PROTEIQUE DE POISSON FISH PRODUCTS FISH PROTEIN CONCENTRATES PRESION SANGUINEA PRESSION SANGUINE PRODUCTOS DERIVADOS DEL PESCADO PRODUIT A BASE DE POISSON |
| title | Hypotensive effect of fish protein hydrolysate |
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