Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells

We investigated the growth inhibitory activity of several flavonoids, including apigenin, luteolin, kaempherol, quercetin, butein, isoliquiritigenin, naringenin, genistein, and daizein against B16 mouse melanoma 4A5 cells. Isoliquiritigenin and butein, belonging to the chalcone group, markedly suppr...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2000-09, Vol.64 (9), p.1813-1820
Hauptverfasser:	Iwashita, K. (Tsukuba Univ., Ibaraki (Japan). Inst. of Applied Biochemistry), Kobori, M, Yamaki, K, Tsushida, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents antiproliferation Apigenin APOPTOSIS Apoptosis - drug effects Bcl-2 family bcl-2-Associated X Protein bcl-X Protein Biological and medical sciences Cell Division - drug effects CELL MEDIATED IMMUNITY CELLS Chalcone - analogs & derivatives Chalcone - toxicity Chalcones Flavanones flavonoid FLAVONOIDS Flavonoids - toxicity General aspects Genistein - toxicity GROWTH INHIBITORS Isoflavones - toxicity Luteolin Medical sciences MELANOMA melanoma cells Melanoma, Experimental MICE Pharmacology. Drug treatments Proto-Oncogene Proteins - analysis Proto-Oncogene Proteins c-bcl-2 - analysis Quercetin - toxicity Structure-Activity Relationship Tumor Cells, Cultured
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