Cloning and nucleotide sequences of two genes involved in the 4"-O-acylation of macrolide antibiotics from Streptomyces thermotolerans

A DNA fragment responsible for the 4"-O-acylation of macrolide antibiotics was cloned from a mutant strain of the carbomycin producer Streptomyces thermotolerans. The gene encoding the macrolide 4"-O-acyltransferase was within a 1.7-kb region of the cloned fragment (15-kb). Streptomyces li...

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