Ectopic Antenna Induction by Overexpression of CG17836/Xrp1 Encoding an AT-Hook DNA Binding Motif Protein in Drosophila
Drosophila imaginal discs are an excellent model system for studies of developmental plasticity. In imaginal discs, most cells adhere strictly to their specific identity, but some cells undergo transdetermination, a process wherein the determined identity switches to another disc-specific identity....
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2013, Vol.77 (2), p.339-344 |
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| creator | TSURUI-NISHIMURA, Noriko NGUYEN, Thanh Quang KATSUYAMA, Tomonori MINAMI, Tatsurou FURUHASHI, Hirofumi OSHIMA, Yoshiteru KURATA, Shoichiro |
| description | Drosophila imaginal discs are an excellent model system for studies of developmental plasticity. In imaginal discs, most cells adhere strictly to their specific identity, but some cells undergo transdetermination, a process wherein the determined identity switches to another disc-specific identity. In this study, we performed gain-of-function screening and identified a gene, CG17836/Xrp1, that induces ectopic antennae in the eye field upon overexpression at the early eye disc stage. An essential factor in the distalization process, Distalles, and its upstream regulators Wingless, Hedgehog, and Decapentaplegic, are ectopically induced by CG17836/Xrp1 overexpression in eye discs, and this provides molecular evidence of the formation of ectopic antennae. Further, forced expression of CG17836/Xrp1 induced severe cell-proliferation defects. These findings suggest that CG17836/Xrp1 is involved in the regulation of cell proliferation in eye discs and affects disc identity specification. |
| doi_str_mv | 10.1271/bbb.120756 |
| format | Article |
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In imaginal discs, most cells adhere strictly to their specific identity, but some cells undergo transdetermination, a process wherein the determined identity switches to another disc-specific identity. In this study, we performed gain-of-function screening and identified a gene, CG17836/Xrp1, that induces ectopic antennae in the eye field upon overexpression at the early eye disc stage. An essential factor in the distalization process, Distalles, and its upstream regulators Wingless, Hedgehog, and Decapentaplegic, are ectopically induced by CG17836/Xrp1 overexpression in eye discs, and this provides molecular evidence of the formation of ectopic antennae. Further, forced expression of CG17836/Xrp1 induced severe cell-proliferation defects. 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In imaginal discs, most cells adhere strictly to their specific identity, but some cells undergo transdetermination, a process wherein the determined identity switches to another disc-specific identity. In this study, we performed gain-of-function screening and identified a gene, CG17836/Xrp1, that induces ectopic antennae in the eye field upon overexpression at the early eye disc stage. An essential factor in the distalization process, Distalles, and its upstream regulators Wingless, Hedgehog, and Decapentaplegic, are ectopically induced by CG17836/Xrp1 overexpression in eye discs, and this provides molecular evidence of the formation of ectopic antennae. Further, forced expression of CG17836/Xrp1 induced severe cell-proliferation defects. These findings suggest that CG17836/Xrp1 is involved in the regulation of cell proliferation in eye discs and affects disc identity specification.</description><subject>Animals</subject><subject>apoptosis</subject><subject>Arthropod Antennae - growth & development</subject><subject>Arthropod Antennae - metabolism</subject><subject>Cell Proliferation</subject><subject>Cell Transdifferentiation</subject><subject>Compound Eye, Arthropod - growth & development</subject><subject>Compound Eye, Arthropod - metabolism</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Drosophila melanogaster - genetics</subject><subject>Drosophila melanogaster - growth & development</subject><subject>Drosophila melanogaster - metabolism</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Hedgehog Proteins - genetics</subject><subject>Hedgehog Proteins - metabolism</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - metabolism</subject><subject>Imaginal Discs - growth & development</subject><subject>Imaginal Discs - metabolism</subject><subject>Morphogenesis - genetics</subject><subject>organ identity</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>transdetermination</subject><subject>Wnt1 Protein - genetics</subject><subject>Wnt1 Protein - metabolism</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMFOGzEQhi1E1QTohQdAPlZI23i8azt7DCGFSLThQKXeLNvrbQ0be7E30Lw9TpP2hDTSjH59-jX6EDoH8gWogInWOh9EMH6ExlBWouB1JY7RmNTAi2nFYIROUnokJAcMPqIRLcsaajodo9eFGULvDJ75wXqv8NI3GzO44LHe4tWLjfZPH21KuyS0eH4DYlryyc_YA154Exrnf2Hl8eyhuA3hCV9_n-Er5__G38LgWnwfw2Cdx3muY0ih_-06dYY-tKpL9tNhn6IfXxcP89vibnWznM_uCsOmYigoJ0wZDQKqmhhBmgqAaGG4Uto0nHLWaEYJEa3VnCuqoVKWAYXG1FVNbXmKPu97-xieNzYNcu2SsV2nvA2bJKEEmg0xEBm93KMmf5mibWUf3VrFrQQid6JlFi33ojN8cejd6LVt_qP_zGaA7QHn2xDX6jXErpGD2nYhtlF545Is3yl-AyKuiXU</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>TSURUI-NISHIMURA, Noriko</creator><creator>NGUYEN, Thanh Quang</creator><creator>KATSUYAMA, Tomonori</creator><creator>MINAMI, Tatsurou</creator><creator>FURUHASHI, Hirofumi</creator><creator>OSHIMA, Yoshiteru</creator><creator>KURATA, Shoichiro</creator><general>Japan Society for Bioscience, Biotechnology, and Agrochemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2013</creationdate><title>Ectopic Antenna Induction by Overexpression of CG17836/Xrp1 Encoding an AT-Hook DNA Binding Motif Protein in Drosophila</title><author>TSURUI-NISHIMURA, Noriko ; NGUYEN, Thanh Quang ; KATSUYAMA, Tomonori ; MINAMI, Tatsurou ; FURUHASHI, Hirofumi ; OSHIMA, Yoshiteru ; KURATA, Shoichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c587t-2605acb171490c70d4110b7c6aabcd6265db52007feb66a2b14ae5121dc9492e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>apoptosis</topic><topic>Arthropod Antennae - growth & development</topic><topic>Arthropod Antennae - metabolism</topic><topic>Cell Proliferation</topic><topic>Cell Transdifferentiation</topic><topic>Compound Eye, Arthropod - growth & development</topic><topic>Compound Eye, Arthropod - metabolism</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Drosophila melanogaster - genetics</topic><topic>Drosophila melanogaster - growth & development</topic><topic>Drosophila melanogaster - metabolism</topic><topic>Drosophila Proteins - genetics</topic><topic>Drosophila Proteins - metabolism</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Hedgehog Proteins - genetics</topic><topic>Hedgehog Proteins - metabolism</topic><topic>Homeodomain Proteins - genetics</topic><topic>Homeodomain Proteins - metabolism</topic><topic>Imaginal Discs - growth & development</topic><topic>Imaginal Discs - metabolism</topic><topic>Morphogenesis - genetics</topic><topic>organ identity</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>transdetermination</topic><topic>Wnt1 Protein - genetics</topic><topic>Wnt1 Protein - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TSURUI-NISHIMURA, Noriko</creatorcontrib><creatorcontrib>NGUYEN, Thanh Quang</creatorcontrib><creatorcontrib>KATSUYAMA, Tomonori</creatorcontrib><creatorcontrib>MINAMI, Tatsurou</creatorcontrib><creatorcontrib>FURUHASHI, Hirofumi</creatorcontrib><creatorcontrib>OSHIMA, Yoshiteru</creatorcontrib><creatorcontrib>KURATA, Shoichiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TSURUI-NISHIMURA, Noriko</au><au>NGUYEN, Thanh Quang</au><au>KATSUYAMA, Tomonori</au><au>MINAMI, Tatsurou</au><au>FURUHASHI, Hirofumi</au><au>OSHIMA, Yoshiteru</au><au>KURATA, Shoichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ectopic Antenna Induction by Overexpression of CG17836/Xrp1 Encoding an AT-Hook DNA Binding Motif Protein in Drosophila</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2013</date><risdate>2013</risdate><volume>77</volume><issue>2</issue><spage>339</spage><epage>344</epage><pages>339-344</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>Drosophila imaginal discs are an excellent model system for studies of developmental plasticity. In imaginal discs, most cells adhere strictly to their specific identity, but some cells undergo transdetermination, a process wherein the determined identity switches to another disc-specific identity. In this study, we performed gain-of-function screening and identified a gene, CG17836/Xrp1, that induces ectopic antennae in the eye field upon overexpression at the early eye disc stage. An essential factor in the distalization process, Distalles, and its upstream regulators Wingless, Hedgehog, and Decapentaplegic, are ectopically induced by CG17836/Xrp1 overexpression in eye discs, and this provides molecular evidence of the formation of ectopic antennae. Further, forced expression of CG17836/Xrp1 induced severe cell-proliferation defects. 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| ispartof | Bioscience, biotechnology, and biochemistry, 2013, Vol.77 (2), p.339-344 |
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| source | J-STAGE Free; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Animals apoptosis Arthropod Antennae - growth & development Arthropod Antennae - metabolism Cell Proliferation Cell Transdifferentiation Compound Eye, Arthropod - growth & development Compound Eye, Arthropod - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Gene Expression Regulation, Developmental Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Imaginal Discs - growth & development Imaginal Discs - metabolism Morphogenesis - genetics organ identity Transcription Factors - genetics Transcription Factors - metabolism transdetermination Wnt1 Protein - genetics Wnt1 Protein - metabolism |
| title | Ectopic Antenna Induction by Overexpression of CG17836/Xrp1 Encoding an AT-Hook DNA Binding Motif Protein in Drosophila |
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